Skip to main content

Research Repository

Advanced Search

What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology

Davies, E.; Rogers, N. K.; Lloyd-Lavery, A.; Grindlay, D. J. C.; Thomas, K. S.


E. Davies

N. K. Rogers

A. Lloyd-Lavery

D. J. C. Grindlay


This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 15 systematic reviews that were published during 2015, and focuses on the epidemiology and methodology issues of AE. For systematic reviews on the prevention and treatment of AE, see Part 2 of this update. The worldwide prevalence of AE during childhood has been calculated to be 7.89% (95% CI 7.88–7.89), based on studies of 1 430 329 children from 102 countries. Children with AE are four times more likely than controls to have allergic rhinitis and asthma [relative risk (RR) = 4.24, 95% CI 3.75–4.79]. Twin studies show the heritability of AE to be about 75%. AE is more prevalent in patients with vitiligo and alopecia, and is positively associated with a high body mass index in America and Asia but not in Europe. Possible relationships between AE and exercise, maternal folate supplementation, maternal stress and autism spectrum disorder (ASD) have been assessed, but more high‐quality studies are needed for definitive conclusions. The Harmonising Outcomes Measures for Eczema (HOME) Initiative is developing a core set of outcome measures for AE trials. Suitable instruments for measuring quality of life are yet to be agreed, and use of Investigator Global Assessment in trials requires standardization. Transparent reporting of AE trials remains problematic.


Davies, E., Rogers, N. K., Lloyd-Lavery, A., Grindlay, D. J. C., & Thomas, K. S. (2018). What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology. Clinical and Experimental Dermatology, 43(4), 375-379. doi:10.1111/ced.13377

Journal Article Type Article
Acceptance Date Jul 26, 2017
Online Publication Date Jan 4, 2018
Publication Date May 9, 2018
Deposit Date Dec 6, 2018
Journal Clinical and Experimental Dermatology
Print ISSN 0307-6938
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 43
Issue 4
Pages 375-379
Public URL
Publisher URL