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Professor KIM THOMAS's Outputs (157)

How do atopic dermatitis trialists perceive the Harmonising Outcomes Measurement in Eczema (HOME) core outcome set? A survey study from the HOME initiative (2025)
Journal Article
Gilad, Y., Simpson, E., Apfelbacher, C., Spuls, P., Thomas, K., Schmitt, J., Gerbens, L., Jacobson, M., Katoh, N., Williams, H., & Leshem, Y. (2025). How do atopic dermatitis trialists perceive the Harmonising Outcomes Measurement in Eczema (HOME) core outcome set? A survey study from the HOME initiative. Clinical and Experimental Dermatology, https://doi.org/10.1093/ced/llaf191

Co-producing a randomized controlled trial on the frequency of bathing in eczema: description of a citizen science approach (2025)
Journal Article
Baker, A., Bonsu, N., Howells, L., Muller, I., Mitchell, E. J., Cowdell, F., Davies, F., Eddis-Finbow, M., Montgomery, A., Patel, D., Putrym, G., Ridd, M. J., Santer, M., Roberts, A., Thomas, K. S., the Rapid Eczema Trials team, Thomas, K. S., Roberts, A., Baker, A., Bonsu, N., …Skelding, S. (2025). Co-producing a randomized controlled trial on the frequency of bathing in eczema: description of a citizen science approach. Skin Health and Disease, 5(2), 130-139. https://doi.org/10.1093/skinhd/vzaf005

Background
Eczema is a prevalent, chronic, itchy skin condition that often persists into adulthood and significantly affects the quality of life of patients and their families. With no cure available at present, effective management is crucial. Alth... Read More about Co-producing a randomized controlled trial on the frequency of bathing in eczema: description of a citizen science approach.

Minimum Important Change for the Patient Evaluation Measure in patients with finger fractures and joint injuries (2025)
Journal Article
Mousoulis, C., Trickett, R. W., Thomas, K. S., Leighton, P., & Karantana, A. (2025). Minimum Important Change for the Patient Evaluation Measure in patients with finger fractures and joint injuries. Journal of Hand Surgery (European Volume), https://doi.org/10.1177/17531934251331727

The Minimum Important Change of the Patient Evaluation Measure for patients recovering from a finger fracture or joint injury was estimated to aid the design of future trials. Data from the Patient Outcomes for Finger Fractures and Joint Injuries pro... Read More about Minimum Important Change for the Patient Evaluation Measure in patients with finger fractures and joint injuries.

Supporting self-care for eczema in the community: the Eczema Care Online research programme including two RCTs (2025)
Journal Article
Muller, I., Stuart, B., Sach, T., Yardley, L., Greenwell, K., Becque, T., Leighton, P., Howells, L., Harvey, J., Hooper, J., Steele, M., Sivyer, K., Ghio, D., Teasdale, E., Axon, E., Lax, S., Clarke, H., Onoja, M., Ahmed, A., Griffiths, G., …Santer, M. (2025). Supporting self-care for eczema in the community: the Eczema Care Online research programme including two RCTs. Programme Grants for Applied Research, 13(3), https://doi.org/10.3310/FNHD8546

Background
Eczema is a common condition with significant impact on quality of life. The main cause of treatment failure is non-use of prescribed treatments because treatments are time-consuming to apply; they may sting when first applied to inflamed... Read More about Supporting self-care for eczema in the community: the Eczema Care Online research programme including two RCTs.

A qualitative interview study exploring patients' views and experiences of treatment for hidradenitis suppurativa in the UK (2025)
Journal Article
Howells, L., Leighton, P., Thomas, K. S., Collier, F., Gibbons, A., Harris, C., Hood, K., Riaz, M., Rodrigues, J., Stanton, H., Thomas-Jones, E., & Ingram, J. R. (2025). A qualitative interview study exploring patients' views and experiences of treatment for hidradenitis suppurativa in the UK. British Journal of Dermatology, 193(1), 85-92. https://doi.org/10.1093/bjd/ljaf046

Background
Hidradenitis suppurativa (HS) is a long-term skin condition where evidence for management after first-line treatment fails is limited and practice varies across the UK. Medical and surgical treatment options are potential avenues of treat... Read More about A qualitative interview study exploring patients' views and experiences of treatment for hidradenitis suppurativa in the UK.

CF Tummy Tracker: A Cystic Fibrosis–Specific Patient-Reported Outcome Measure for Daily Gastrointestinal Symptom Burden (2025)
Journal Article
Calthorpe, R. J., Saumtally, H. A., Howells, L. M., Goodchild, N. J., Evans, B. C., Elliott, Z., Hayee, B. H., Carr, S. B., Elston, C. M., Horsley, A. A., Peckham, D. G., Barr, H. L., Major, G. A., Stewart, I. D., Thomas, K. S., & Smyth, A. R. (2025). CF Tummy Tracker: A Cystic Fibrosis–Specific Patient-Reported Outcome Measure for Daily Gastrointestinal Symptom Burden. Mayo Clinic Proceedings: Digital Health, 3(2), Article 100203. https://doi.org/10.1016/j.mcpdig.2025.100203

Objective
To develop a cystic fibrosis (CF)–specific patient-reported outcome measure (PROM) to measure the daily burden of gastrointestinal symptoms for people with cystic fibrosis (pwCF) aged 12 years and older and address the lack of validated ou... Read More about CF Tummy Tracker: A Cystic Fibrosis–Specific Patient-Reported Outcome Measure for Daily Gastrointestinal Symptom Burden.

Achieving long-term control in atopic dermatitis: emerging concepts, definitions, flares and therapy (2025)
Journal Article
Williams, H. C., Simpson, E. L., Langan, S. M., Roberts, A., & Thomas, K. S. (in press). Achieving long-term control in atopic dermatitis: emerging concepts, definitions, flares and therapy. Journal of Allergy and Clinical Immunology: In Practice, https://doi.org/10.1016/j.jaip.2025.02.013

For most people, atopic dermatitis or AD (syn. atopic or just eczema) is a chronic relapsing inflammatory condition with flares and periods of relative control/remission. Given that such a chronic course typically lasts years, it is odd that the conc... Read More about Achieving long-term control in atopic dermatitis: emerging concepts, definitions, flares and therapy.

Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online) (2025)
Journal Article
Howells, L., Thomas, K. S., Santer, M., Muller, I., Greenwell, K., Roberts, A., Williams, H. C., Harvey, J., Lax, S. J., Rogers, N. K., Sach, T. H., Lawton, S., Steele, M., Sivyer, K., Hooper, J., Ahmed, A., Wilczynska, S., Langan, S., & Leighton, P. (2025). Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online). BMC Health Services Research, 25(1), Article 187. https://doi.org/10.1186/s12913-024-12179-2

Background
Eczema Care Online (www.EczemaCareOnline.org.uk/) is an online self-management toolkit which includes tailored content for young people (13–25 years) and for parents of children that have eczema (0–12 years). Testing in two randomised con... Read More about Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online).

Determining the minimal important change of the recap of atopic eczema (RECAP) instrument in clinical trials (2024)
Journal Article
Baker, A., Stuart, B., Howells, L., J. Mitchell, E., & S. Thomas, K. (2024). Determining the minimal important change of the recap of atopic eczema (RECAP) instrument in clinical trials. Skin Health and Disease, 4(6), Article ski2.470. https://doi.org/10.1002/ski2.470

Background

The Recap of atopic eczema (RECAP) is a patient-reported instrument designed to assess eczema control. There is a lack of evidence on the interpretability of change scores in clinical trials.

Objectives

To calculate the smallest d... Read More about Determining the minimal important change of the recap of atopic eczema (RECAP) instrument in clinical trials.

Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years (2024)
Journal Article
Sach, T. H., Williams, H. C., Allen, H., Boyle, R., Kelleher, M., Brown, S., Cork, M., Flohr, C., Jay, N., Lartey, S., Davies, C., Lawton, S., Perkin, M., Ridd, M., Brooks, J., Tarr, S., Wyatt, L., & Thomas, K. (2024). Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years. Value in Health, https://doi.org/10.1016/j.jval.2024.08.010


Objectives
To assess the practicality, validity and responsiveness of proxy CHU-9D in children aged 2-5 years.

Methods
We used data from BEEP, a UK randomised co... Read More about Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years.

Expert opinion on characteristics of vulval lichen sclerosus: initial identification of important clinical features through an international electronic Delphi consensus study (2024)
Journal Article
Simpson, R. C., Birchall, M., Daniels, J., Gran, S., Kirtschig, G., & Thomas, K. S. (2025). Expert opinion on characteristics of vulval lichen sclerosus: initial identification of important clinical features through an international electronic Delphi consensus study. Clinical and Experimental Dermatology, 50(3), 590-596. https://doi.org/10.1093/ced/llae393

Background Lichen sclerosus (LS) is a chronic inflammatory condition that mainly affects genital skin. It causes distressing symptoms that impact daily quality of life, as well as progressive anatomical changes and a potential risk of cancer. Vulval... Read More about Expert opinion on characteristics of vulval lichen sclerosus: initial identification of important clinical features through an international electronic Delphi consensus study.

Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT (2024)
Journal Article
Santer, M., Lawrence, M., Pyne, S., Renz, S., Stuart, B. L., Sach, T., Ridd, M., Thomas, K. S., Nuttall, J., Permyakova, N., Eminton, Z., Francis, N., Little, P., Muller, I., Soulsby, I., Thomas, K., Griffiths, G., & Layton, A. M. (2024). Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT. Health Technology Assessment, 28(56), https://doi.org/10.3310/MYJT6804

Background: Acne is common, can cause significant impact on quality of life and is a frequent reason for long-term antibiotic use. Spironolactone has been prescribed for acne in women for many years, but robust evidence is lacking. Objective: To eval... Read More about Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT.

Rapid Eczema Trials: Addressing patient priorities from the eczema priority setting partnership (2024)
Journal Article
Campbell, E. L., Fong, W. C. G., Roberts, A., & Thomas, K. S. (2025). Rapid Eczema Trials: Addressing patient priorities from the eczema priority setting partnership. British Journal of Dermatology, 192(1), 173-175. https://doi.org/10.1093/bjd/ljae362

In this letter, we describe the Rapid Eczema Trials co-production project, which aims to plug some of the research gaps that remain following the 2011 James Lind Alliance Eczema Priority Setting Partnership (PSP) exercise. We highlight similarities b... Read More about Rapid Eczema Trials: Addressing patient priorities from the eczema priority setting partnership.

Capturing and reporting topical treatment use in childhood eczema: lessons for data collection in eczema trials (2024)
Journal Article
Memory, K. E., Macneill, S. J., Thomas, K. S., Santer, M., & Ridd, M. J. (2025). Capturing and reporting topical treatment use in childhood eczema: lessons for data collection in eczema trials. Clinical and Experimental Dermatology, 50(3), 580-589. https://doi.org/10.1093/ced/llae328

Background Emollients and topical corticosteroids (TCS) prevent and treat flares in eczema. However, topical treatment use is poorly recorded and reported in clinical trials. There is no clear consensus of how best to capture and summarize topical tr... Read More about Capturing and reporting topical treatment use in childhood eczema: lessons for data collection in eczema trials.

Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT (2024)
Journal Article
Wyatt, L. A., Bradshaw, L. E., Brown, S. J., Haines, R. H., Montgomery, A. A., Perkin, M. R., Sach, T. H., Lawton, S., Flohr, C., Ridd, M. J., Chalmers, J. R., Brooks, J., Swinden, R., Mitchell, E. J., Tarr, S., Jay, N., Thomas, K. S., Allen, H., Cork, M. J., Kelleher, M. M., …Williams, H. C. (2024). Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT. Health Technology Assessment, 28(29), 1-116. https://doi.org/10.3310/rhdn9613

Background

Atopic eczema is a common childhood skin problem linked with asthma, food allergy and allergic rhinitis that impairs quality of life.

Objectives

To determine whether advising parents to apply daily emollients in the first year can... Read More about Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.

P078 Establishing diagnostic criteria for vulval lichen sclerosus (SHELLS): an international electronic-Delphi consensus study (2024)
Journal Article
Simpson, R., Birchall, M., Daniels, J., Gran, S., Kirtschig, G., & Thomas, K. (2024). P078 Establishing diagnostic criteria for vulval lichen sclerosus (SHELLS): an international electronic-Delphi consensus study. British Journal of Dermatology, 191(Supplement_1), i51-i51. https://doi.org/10.1093/bjd/ljae090.105

Lichen sclerosus (LS) is a chronic inflammatory condition mainly affecting genital skin. It causes distressing symptoms that impact daily quality of life, results in progressive anatomical changes and has a potential risk of cancer. There is no defin... Read More about P078 Establishing diagnostic criteria for vulval lichen sclerosus (SHELLS): an international electronic-Delphi consensus study.

A multifaceted and standardized approach is needed to improve acne severity assessment in clinical practice: an online survey of UK health professionals (2024)
Journal Article
Masterson, N., Burden-Teh, E., Healy, E., Hepburn, T., Layfield, C., Layton, A., Leighton, P., Leng, S., Mitchell, E., Northover, G., Penzer-Hick, R., Price, W., Radley, K., Ramesh, G., Ravenscroft, J. C., Sach, T., Sadiq, S., Santer, M., Thomas, K. S., Thompson, A., …the Acne-ID Trial Development Team. (2025). A multifaceted and standardized approach is needed to improve acne severity assessment in clinical practice: an online survey of UK health professionals. Clinical and Experimental Dermatology, 50(1), 158-160. https://doi.org/10.1093/ced/llae180