Professor TONY AVERY's Outputs (99)

Understanding the scale and nature of avoidable healthcare-associated harm for prisoners in England: protocol for a retrospective cross-sectional study (2024)
Journal Article
Carson-Stevens, A., McFadzean, I. J., Purchase, T., Gwyn, S., Hellard, S., Davies, K., Ashcroft, D. M., Avery, A., Campbell, S., Edwards, A., Flynn, S., Hewson, T., Ibrahim, S., Jordan, M., Keers, R. N., Millar, T., Panagioti, M., Sanders, C., Senior, J., Stevenson, C., …Shaw, J. (2024). Understanding the scale and nature of avoidable healthcare-associated harm for prisoners in England: protocol for a retrospective cross-sectional study. BMJ Open, 14(12), Article e085607. https://doi.org/10.1136/bmjopen-2024-085607

Introduction Around 1 in 20 patients experience avoidable healthcare-associated harm worldwide. Despite longstanding concerns, there is insufficient information available about the safety of healthcare for prisoners. To address this, this study will... Read More about Understanding the scale and nature of avoidable healthcare-associated harm for prisoners in England: protocol for a retrospective cross-sectional study.

Key stakeholder's attitudes towards the professional accountabilities and responsibilities of newly qualified Pharmacist Independent Prescribers (IPs) in England and enablers to implementation at scale? (2024)
Journal Article
Warner, B., Thornley, T., Anderson, C., & Avery, A. (2025). Key stakeholder's attitudes towards the professional accountabilities and responsibilities of newly qualified Pharmacist Independent Prescribers (IPs) in England and enablers to implementation at scale?. Health Policy, 152, Article 105223. https://doi.org/10.1016/j.healthpol.2024.105223

Background: Independent prescribing is set to expand amongst community pharmacists in England in the next few years. This study aims to explore the different accountabilities and responsibilities associated with independent prescribing compared to mo... Read More about Key stakeholder's attitudes towards the professional accountabilities and responsibilities of newly qualified Pharmacist Independent Prescribers (IPs) in England and enablers to implementation at scale?.

Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, UK (2024)
Journal Article
Knaggs, R., Wilson, L., Boyd, M., Thornley, T., & Avery, T. (in press). Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, UK. PAIN Reports,

Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study (2024)
Journal Article
Iyen, B., Coupland, C., Bell, B., Orrell, M., Dening, T., & Avery, T. (2024). Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study. BMJ Medicine, 3(1), Article e000799. https://doi.org/10.1136/bmjmed-2023-000799

Objective To investigate whether different anticholinergic drug treatments for overactive bladder have differential risks for incident dementia, in a large representative population of older adults in England.

Design Nested case-control study.... Read More about Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study.

Short-Term Risk of Cardiovascular Events in People Newly Diagnosed With Gout (2024)
Journal Article
Cipolletta, E., Nakafero, G., Richette, P., Avery, A. J., Mamas, M. A., Tata, L. J., & Abhishek, A. (2024). Short-Term Risk of Cardiovascular Events in People Newly Diagnosed With Gout. Arthritis and Rheumatology, https://doi.org/10.1002/art.42986

Objective
To investigate the temporal association between first diagnosis of gout and cardiovascular events in the short-term.

Methods
We performed a self-controlled case series analysis and a cohort study using data from linked primary care, ho... Read More about Short-Term Risk of Cardiovascular Events in People Newly Diagnosed With Gout.

Cardiovascular events in gout patients starting urate-lowering therapy with or without colchicine for flare prophylaxis: a new-user cohort study using linked primary care, hospitalisation and mortality data (2024)
Journal Article
CIPOLLETTA, E., Nakafero, G., McCormick, N., Yokose, C., Avery, A., Mamas, M., Choi, H., Tata, L., & Abhishek, A. (in press). Cardiovascular events in gout patients starting urate-lowering therapy with or without colchicine for flare prophylaxis: a new-user cohort study using linked primary care, hospitalisation and mortality data. The Lancet Rheumatology,

Background Starting urate-lowering therapy (ULT) may trigger gout flares. Gout flares have been temporally associated with an increased risk of cardiovascular events (CVEs).
Objective To estimate the risk of CVEs among patients with gout initiating... Read More about Cardiovascular events in gout patients starting urate-lowering therapy with or without colchicine for flare prophylaxis: a new-user cohort study using linked primary care, hospitalisation and mortality data.

The impact of ageing on adults with cerebral palsy (2023)
Journal Article
Bell, B., Shah, S., Coulson, N., McLaughlin, J., Logan, P., Luke, R., & Avery, A. J. (2023). The impact of ageing on adults with cerebral palsy. British Journal of General Practice Open, 7(4), Article 0028. https://doi.org/10.3399/BJGPO.2023.0028

Background Cerebral palsy (CP) is one of the most common neurological disorders in children and results in lifelong physical impairments. Adults with CP have approximately the same life expectancy as their non-disabled peers, so helping them to stay... Read More about The impact of ageing on adults with cerebral palsy.

Evaluating the UK's first national prescribing assessment for GPs in training using an online survey (2023)
Journal Article
Knox, R., Bell, B., Salema, N., Emerson, K., Bodgener, S., Rial, J., Gookey, G., Swanwick, G., Charly, A., & Avery, A. J. (2023). Evaluating the UK's first national prescribing assessment for GPs in training using an online survey. BJGP Open, 7(4), Article 044. https://doi.org/10.3399/BJGPO.2023.0044

Background GP trainees may not have experienced a systematic and comprehensive education in safe prescribing. Therefore, a self-assessment prescribing review was developed.

Aim To determine whether the assessment was feasible, had face validity, a... Read More about Evaluating the UK's first national prescribing assessment for GPs in training using an online survey.

Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records (2023)
Journal Article
Joseph, R. M., Knaggs, R. D., Coupland, C. A., Taylor, A., Vinogradova, Y., Butler, D., Gerrard, L., Waldram, D., Iyen, B., Akyea, R. K., Ashcroft, D. M., Avery, A. J., & Jack, R. H. (2023). Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records. BMC Geriatrics, 23(1), Article 435. https://doi.org/10.1186/s12877-023-04143-2

Background Medication reviews in primary care provide an opportunity to review and discuss the safety and appropriateness of a person’s medicines. However, there is limited evidence about access to and the impact of routine medication reviews for old... Read More about Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records.

Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics (2023)
Journal Article
Fisher, L., Hopcroft, L. E., Rodgers, S., Barrett, J., Oliver, K., Avery, A. J., Evans, D., Curtis, H., Croker, R., Macdonald, O., Morley, J., Mehrkar, A., Bacon, S., Davy, S., Dillingham, I., Evans, D., Hickman, G., Inglesby, P., Morton, C. E., Smith, B., …MacKenna, B. (2023). Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics. BMJ Medicine, 2(1), Article e000392. https://doi.org/10.1136/bmjmed-2022-000392

Objective: To implement complex, PINCER (pharmacist led information technology intervention) prescribing indicators, on a national scale with general practice data to describe the impact of the covid-19 pandemic on safe prescribing.

Design: Popula... Read More about Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics.

Patient safety in prisons: a multi-method analysis of reported incidents in England (2023)
Journal Article
McFadzean, I. J., Davies, K., Purchase, T., Edwards, A., Hellard, S., Ashcroft, D. M., Avery, A. J., Flynn, S., Hewson, T., Jordan, M., Keers, R., Panagioti, M., Wainwright, V., Walter, F., Shaw, J., & Carson-Stevens, A. (2023). Patient safety in prisons: a multi-method analysis of reported incidents in England. Journal of the Royal Society of Medicine, 116(7), 236-245. https://doi.org/10.1177/01410768231166138

Objectives
Prisoners use healthcare services three times more frequently than the general population with poorer health outcomes. Their distinct healthcare needs often pose challenges to safe healthcare provision. This study aimed to characterise pa... Read More about Patient safety in prisons: a multi-method analysis of reported incidents in England.

Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration (2023)
Journal Article
Cattell, M., Hyde, K., Bell, B., Dawson, T., Hills, T., Iyen, B., Khimji, A., & Avery, A. (in press). Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration. European Journal of Hospital Pharmacy, Article 003515. https://doi.org/10.1136/ejhpharm-2022-003515

Objectives
To describe the frequency of the different types of medication-related incidents that caused patient harm, or adverse consequences, in a major teaching hospital and investigate whether the likelihood of these incidents occurring would hav... Read More about Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration.

Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration (2023)
Journal Article
Cattell, M., Hyde, K., Bell, B., Dawson, T., Hills, T., Iyen, B., Khimji, A., & Avery, A. (2023). Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration. European Journal of Hospital Pharmacy, 31(4), 295-300. https://doi.org/10.1136/ejhpharm-2022-003515

Objectives: To describe the frequency of the different types of medication-related incidents that caused patient harm, or adverse consequences, in a major teaching hospital and investigate whether the likelihood of these incidents occurring would hav... Read More about Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration.

Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study (2022)
Journal Article
Rodgers, S., Taylor, A. C., Roberts, S. A., Allen, T., Ashcroft, D. M., Barrett, J., Boyd, M. J., Elliott, R. A., Khunti, K., Sheikh, A., Laparidou, D., Siriwardena, A. N., & Avery, A. J. (2022). Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study. PLoS Medicine, 19(11), Article e1004133. https://doi.org/10.1371/journal.pmed.1004133

Background: We previously reported on a randomised trial demonstrating the effectiveness and cost-effectiveness of a pharmacist-led information technology intervention (PINCER). We sought to investigate whether PINCER was effective in reducing hazard... Read More about Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study.

Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial (2022)
Journal Article
Hawkey, C., Avery, A., Coupland, C. A., Crooks, C., Dumbleton, J., Hobbs, F. D. R., Kendrick, D., Moore, M., Morris, C., Rubin, G., Smith, M., Stevenson, D., Mant, D., Ford, A., Macdonald, T., Bradburn, M., Ward, C., Shone, A., Logan, R., McColl, K., …Hodgson, S. (2022). Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial. Lancet, 400(10363), 1597-1606. https://doi.org/10.1016/S0140-6736%2822%2901843-8

Background: Peptic ulcers in patients receiving aspirin are associated with Helicobacter pylori infection. We aimed to investigate whether H pylori eradication would protect against aspirin-associated ulcer bleeding. Methods: We conducted a randomise... Read More about Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial.

Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial (2022)
Journal Article
Mackenzie, I. S., Hawkey, C. J., Ford, I., Greenlaw, N., Pigazzani, F., Rogers, A., Struthers, A. D., Begg, A. G., Wei, L., Avery, A. J., Taggar, J. S., Walker, A., Duce, S. L., Barr, R. J., Dumbleton, J. S., Rooke, E. D., Townend, J. N., Ritchie, L. D., & MacDonald, T. M. (2022). Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial. Lancet, 400(10359), 1195-1205. https://doi.org/10.1016/S0140-6736%2822%2901657-9

Background: Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed to determine whether allopurinol t... Read More about Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial.

Understanding factors that could influence patient acceptability of the use of the PINCER intervention in primary care: A qualitative exploration using the Theoretical Framework of Acceptability (2022)
Journal Article
Laing, L., Salema, N.-E., Jeffries, M., Shamsuddin, A., Sheikh, A., Chuter, A., Waring, J., Avery, A., & Keers, R. N. (2022). Understanding factors that could influence patient acceptability of the use of the PINCER intervention in primary care: A qualitative exploration using the Theoretical Framework of Acceptability. PLoS ONE, 17(10), Article e0275633. https://doi.org/10.1371/journal.pone.0275633

Introduction Medication errors are an important cause of morbidity and mortality. The pharmacist-led IT-based intervention to reduce clinically important medication errors (PINCER) intervention was shown to reduce medication errors when tested in a c... Read More about Understanding factors that could influence patient acceptability of the use of the PINCER intervention in primary care: A qualitative exploration using the Theoretical Framework of Acceptability.

Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme (2022)
Journal Article
Sheikh, A., Coleman, J., Chuter, A., Williams, R., Lilford, R., Slee, A., Morrison, Z., Cresswell, K., Robertson, A., Slight, S., Mozaffar, H., Lee, L., Shah, S., Pontefract, S., King, A., Wiegel, V., Watson, S., Salema, N.-E., Bates, D., Avery, A., …Watson, N. (2022). Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme. Programme Grants for Applied Research, 10(7), 1-164. https://doi.org/10.3310/KSRS2009

Background:
There is a need to identify approaches to reduce medication errors. Interest has converged on ePrescribing systems that incorporate computerised provider order entry and clinical decision support functionality.

Objectives:
We soug... Read More about Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme.

Understanding factors influencing uptake and sustainable use of the PINCER intervention at scale: A qualitative evaluation using Normalisation Process Theory (2022)
Journal Article
Laing, L., Salema, N. E., Jeffries, M., Shamsuddin, A., Sheikh, A., Chuter, A., Waring, J., Avery, A., & Keers, R. N. (2022). Understanding factors influencing uptake and sustainable use of the PINCER intervention at scale: A qualitative evaluation using Normalisation Process Theory. PLoS ONE, 17(9), Article e0274560. https://doi.org/10.1371/journal.pone.0274560

INTRODUCTION: Medication errors are an important cause of morbidity and mortality. The pharmacist-led IT-based intervention to reduce clinically important medication errors (PINCER) has demonstrated improvements in primary care medication safety, and... Read More about Understanding factors influencing uptake and sustainable use of the PINCER intervention at scale: A qualitative evaluation using Normalisation Process Theory.

The frequency and nature of prescribing problems by GPs-in-training (REVISiT): a retrospective review (2022)
Journal Article
Salema, N. E., Bell, B., Marsden, K., Gookey, G., Swanwick, G., Bassi, M., Mehta, R., Silcock, N., Avery, A. J., & Knox, R. (2022). The frequency and nature of prescribing problems by GPs-in-training (REVISiT): a retrospective review. BJGP Open, 6(3), Article BJGPO.2021.0231. https://doi.org/10.3399/BJGPO.2021.0231

Background: Prescribing errors can cause significant morbidity and occur in about 5% of prescriptions in English general practices. Aim: To describe the frequency and nature of prescribing problems in a cohort of GPs-in-training to determine whether... Read More about The frequency and nature of prescribing problems by GPs-in-training (REVISiT): a retrospective review.