All Outputs (559)

Systematic Identification of Familial Hypercholesterolaemia in Primary Care—A Systematic Review (2021)
Journal Article
Silva, L., Qureshi, N., Abdul-Hamid, H., Weng, S., Kai, J., & Leonardi-Bee, J. (2021). Systematic Identification of Familial Hypercholesterolaemia in Primary Care—A Systematic Review. Journal of Personalized Medicine, 11(4), Article 302. https://doi.org/10.3390/jpm11040302

Familial hypercholesterolaemia (FH) is a common inherited cause of premature cardiovascular disease, but the majority of patients remain undiagnosed. The aim of this systematic review was to assess the effectiveness of interventions to systematically... Read More about Systematic Identification of Familial Hypercholesterolaemia in Primary Care—A Systematic Review.

Helping Us Grow generations of GPs (HUGG): A pilot study evaluating Longitudinal Support Networks (LSNs) on recruitment, retention and resilience of GPs in Derbyshire (2021)
Journal Article
Imtiaz-Umer, S., Taggar, J., & Allsopp, G. (2021). Helping Us Grow generations of GPs (HUGG): A pilot study evaluating Longitudinal Support Networks (LSNs) on recruitment, retention and resilience of GPs in Derbyshire. Education for Primary Care, 32(3), 182-184. https://doi.org/10.1080/14739879.2021.1897955

Aim: To understand if longitudinal support networks (LSNs), including all career stages in General Practice (GP) from medical school to retirement, provide informal cross-generational support impacting on recruitment, retention and resilience of GPs... Read More about Helping Us Grow generations of GPs (HUGG): A pilot study evaluating Longitudinal Support Networks (LSNs) on recruitment, retention and resilience of GPs in Derbyshire.

Clinical placements in General Practice: concepts and considerations of implementing remote virtual placements in the COVID world (2021)
Journal Article
Taggar, J. S., Saha, R., Hopwood-Carr, P., Patel, B., & Johnson, C. (2021). Clinical placements in General Practice: concepts and considerations of implementing remote virtual placements in the COVID world. Education for Primary Care, 32(4), 237-244. https://doi.org/10.1080/14739879.2021.1907790

Medical students are considered as ‘essential workers’ within the National Health Service (NHS) and the delivery of clinical experience is essential to their learning and progression into the workforce. The COVID-19 pandemic impacted on the delivery... Read More about Clinical placements in General Practice: concepts and considerations of implementing remote virtual placements in the COVID world.

Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol (2021)
Journal Article
Dambha-Miller, H., San Tan, P., Saatci, D., Kieran Clift, A., Zaccardi, F., Coupland, C., …Hippisley-Cox, J. (2021). Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol. BMJ Open, 11(4), Article e045286. https://doi.org/10.1136/bmjopen-2020-045286

Introduction: Recent evidence suggests that ethnic minority groups are disproportionately at increased risk of hospitalisation and death from SARS-CoV-2 infection. Population-based evidence on potential explanatory factors across minority groups and... Read More about Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol.

From policy to patient: Using a socio-ecological framework to explore the factors influencing safe practice in UK primary care (2021)
Journal Article
Litchfield, I., Perryman, K., Campbell, S., Avery, A., Gill, P., & Greenfield, S. (2021). From policy to patient: Using a socio-ecological framework to explore the factors influencing safe practice in UK primary care. Social Science and Medicine, 277, Article 113906. https://doi.org/10.1016/j.socscimed.2021.113906

Background: The recent and rapid changes in the model of primary care delivery have led to an increased focus on patient safety in what is one of the most diverse and complex healthcare settings. However, previous initiatives have failed to deliver t... Read More about From policy to patient: Using a socio-ecological framework to explore the factors influencing safe practice in UK primary care.

A digital behaviour change intervention to increase booking and attendance at Stop Smoking Services: the MyWay feasibility RCT (2021)
Journal Article
Fulton, E. A., Newby, K., Kwah, K., Schumacher, L., Gokal, K., Jackson, L. J., …Brown, K. E. (2021). A digital behaviour change intervention to increase booking and attendance at Stop Smoking Services: the MyWay feasibility RCT. Public Health Research, 9(5), 1-62. https://doi.org/10.3310/phr09050

Background: Smoking remains a leading cause of illness and preventable death. NHS Stop Smoking Services increase quitting, but, as access is in decline, cost-effective interventions are needed that promote these services. StopApp™ (Coventry Universit... Read More about A digital behaviour change intervention to increase booking and attendance at Stop Smoking Services: the MyWay feasibility RCT.

Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study (2021)
Journal Article
Aveyard, P., Gao, M., Lindson, N., Hartmann-Boyce, J., Watkinson, P., Young, D., …Hippisley-Cox, J. (2021). Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study. Lancet Respiratory Medicine, 9(8), 909-923. https://doi.org/10.1016/S2213-2600%2821%2900095-3

Background: The aim was to assess whether chronic lung disease or use of inhaled corticosteroids (ICS) affect the risk of contracting severe COVID-19. Methods: English general practice records from the QResearch database were linked to Public Hea... Read More about Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study.

The evaluation of an e-learning prescribing course for general practice (2021)
Journal Article
Salema, N., Clement, N., Hysenagolli, R., Hibberd, R., Bell, B. G., Gookey, G., …Knox, R. (2021). The evaluation of an e-learning prescribing course for general practice. Education for Primary Care, 32(4), 219-225. https://doi.org/10.1080/14739879.2021.1874250

Prescribed medication may lead to significant morbidity or mortality as a result of these medications causing adverse events, or because of a prescribing error. E-learning is a common tool used in supporting training in prescribing. This paper descri... Read More about The evaluation of an e-learning prescribing course for general practice.

Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales (2021)
Journal Article
McMenamin, Ú., Hicks, B., Hughes, C., Murchie, P., Hippisley-Cox, J., Ranger, T., …Cardwell, C. (in press). Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales. BMC Cancer, 21, Article 313. https://doi.org/10.1186/s12885-021-08065-3

Background: Hormone replacement therapy (HRT) is widely used and has proven benefits for women with menopausal symptoms. An increasing number of women with cancer experience menopausal symptoms but the safety of HRT use in women with cancer is uncl... Read More about Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales.

Identifying anticholinergic burden in clinical practice (2021)
Journal Article
Bell, B., & Avery, A. (2021). Identifying anticholinergic burden in clinical practice. Prescriber, 32(3), 20-23. https://doi.org/10.1002/psb.1901

Anticholinergic medications are associated with a wide range of adverse effects to which elderly patients are particularly susceptible. This article discusses the various ways that anticholinergic burden can be measured, how these can be used to help... Read More about Identifying anticholinergic burden in clinical practice.

Trends in prescribing of nicotine replacement therapy to pregnant women in primary care in England (2021)
Journal Article
Szatkowski, L., Reeves Vaz, L., Fiaschi, L., Tata, L., & Coleman, T. (2021). Trends in prescribing of nicotine replacement therapy to pregnant women in primary care in England. Nicotine and Tobacco Research, 23(9), 1607-1610. https://doi.org/10.1093/ntr/ntab037

Introduction: Smoking during pregnancy remains common and the English National Health Service (NHS) has recently been directed to prioritise providing cessation support for pregnant women. We investigated the impact on prescribing of stop smoking tre... Read More about Trends in prescribing of nicotine replacement therapy to pregnant women in primary care in England.

Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch. East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series, 38, 1-16

Introduction: Research from clinical trials of hormone replacement therapy (HRT) has produced conflicting findings about possible risks of dementia after receiving these treatments, and further research on HRT and dementia risk has been identified as... Read More about Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch.

Patient Perspectives on Key Outcomes for Vocational Rehabilitation Interventions Following Traumatic Injury (2021)
Journal Article
Bridger, K., Kellezi, B., Kendrick, D., Radford, K., Timmons, S., Rennoldson, M., …Kettlewell, J. (2021). Patient Perspectives on Key Outcomes for Vocational Rehabilitation Interventions Following Traumatic Injury. International Journal of Environmental Research and Public Health, 18(4), Article 2035. https://doi.org/10.3390/ijerph18042035

Returning to work after traumatic injury can have a range of benefits, but there is currently little research that incorporates patient perspectives to identify outcomes of vocational rehabilitation interventions that are important to survivors. Trau... Read More about Patient Perspectives on Key Outcomes for Vocational Rehabilitation Interventions Following Traumatic Injury.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England (2021)
Journal Article
Persson, M., Harman, K., Thomas, K., Chalmers, J., Vinogradova, Y., Langan, S., …Gran, S. (2021). Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England. BMC Medical Research Methodology, 21(1), Article 22. https://doi.org/10.1186/s12874-021-01212-1

Background Trials of novel agents are required to improve the care of patients with rare diseases, but trial feasibility may be uncertain due to concerns over insufficient patient numbers. We aimed to determine the size of the pool of potential part... Read More about Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England.

‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study (2021)
Journal Article
Orton, E., Audsley, S., Coupland, C., Gladman, J. R., Iliffe, S., Lafond, N., …Kendrick, D. (2021). ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study. Age and Ageing, 50(4), 1290-1297. https://doi.org/10.1093/ageing/afaa288

Background Falls incidence increases with age alongside declines in strength and balance. Clinical trials show that the Falls Management Exercise (FaME) programme improves strength and balance, which can reduce falls and improve physical functioning... Read More about ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study.

Sex, Age, and Socioeconomic Differences in Nonfatal Stroke Incidence and Subsequent Major Adverse Outcomes (2021)
Journal Article
Akyea, R. K., Vinogradova, Y., Qureshi, N., Patel, R. S., Kontopantelis, E., Ntaios, G., …Weng, S. F. (2021). Sex, Age, and Socioeconomic Differences in Nonfatal Stroke Incidence and Subsequent Major Adverse Outcomes. Stroke, 52(2), 396-405. https://doi.org/10.1161/strokeaha.120.031659

Background and Purpose: Data about variations in stroke incidence and subsequent major adverse outcomes are essential to inform secondary prevention and prioritizing resources to those at the greatest risk of major adverse end points. We aimed to de... Read More about Sex, Age, and Socioeconomic Differences in Nonfatal Stroke Incidence and Subsequent Major Adverse Outcomes.

A master protocol to investigate a novel therapy acetyl-l-leucine for three ultra-rare neurodegenerative diseases: Niemann-Pick type C, the GM2 gangliosidoses, and ataxia telangiectasia (2021)
Journal Article
Fields, T., Patterson, M., Bremova-Ertl, T., Belcher, G., Billington, I., Churchill, G. C., …Strupp, M. (2021). A master protocol to investigate a novel therapy acetyl-l-leucine for three ultra-rare neurodegenerative diseases: Niemann-Pick type C, the GM2 gangliosidoses, and ataxia telangiectasia. Trials, 22, Article 84. https://doi.org/10.1186/s13063-020-05009-3

Background: The lack of approved treatments for the majority of rare diseases is reflective of the unique challenges of orphan drug development. Novel methodologies, including new functionally relevant endpoints, are needed to render the development... Read More about A master protocol to investigate a novel therapy acetyl-l-leucine for three ultra-rare neurodegenerative diseases: Niemann-Pick type C, the GM2 gangliosidoses, and ataxia telangiectasia.

Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study (2021)
Working Paper
Blake, H., Knight, H., Jia, R., Corner, J., Morling, J. R., Denning, C., …Vedhara, K. Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups conduc... Read More about Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study.

Vocational rehabilitation to enhance return to work after trauma (ROWTATE): protocol for a non-randomised single-arm mixed-methods feasibility study (2021)
Journal Article
Kendrick, D., das Nair, R., Kellezi, B., Morriss, R., Kettlewell, J., Holmes, J., …Radford, K. (2021). Vocational rehabilitation to enhance return to work after trauma (ROWTATE): protocol for a non-randomised single-arm mixed-methods feasibility study. Pilot and Feasibility Studies, 7(1), Article 29. https://doi.org/10.1186/s40814-021-00769-4

Background Traumatic injuries are common amongst working age adults. Survivors often experience physical and psychological problems, reduced quality of life and difficulty returning to work. Vocational rehabilitation improves work outcomes for a ran... Read More about Vocational rehabilitation to enhance return to work after trauma (ROWTATE): protocol for a non-randomised single-arm mixed-methods feasibility study.