All Outputs (577)

What factors influence smoking prevalence and smoke free policy enactment across the European Union Member States (2011)
Journal Article
Bogdanovica, I., McNeill, A., Murray, R., & Britton, J. (2011). What factors influence smoking prevalence and smoke free policy enactment across the European Union Member States. PLoS ONE, 6(8), Article e23889. https://doi.org/10.1371/journal.pone.0023889

Background Smoking prevention should be a primary public health priority for all governments, and effective preventive policies have been identified for decades. The heterogeneity of smoking prevalence between European Union (EU) Member States the... Read More about What factors influence smoking prevalence and smoke free policy enactment across the European Union Member States.

Hurricanes and child health: lessons from Cuba (2011)
Journal Article
Sánchez Miranda, D., & Choonara, I. (2011). Hurricanes and child health: lessons from Cuba. Archives of Disease in Childhood, 96(4), https://doi.org/10.1136/adc.2009.178145

Armed conflict and child health (2011)
Journal Article
Rieder, M., & Choonara, I. (2012). Armed conflict and child health. Archives of Disease in Childhood, 97(1), 59-62. https://doi.org/10.1136/adc.2009.178186

Armed conflict has a major impact on child health throughout the world. One in six children worldwide lives in an area of armed conflict and civilians are more likely to die than soldiers as a result of the conflict. In stark contrast to the effe... Read More about Armed conflict and child health.

Ciprofloxacin safety in paediatrics: a systematic review (2011)
Journal Article
Adefurin, A., Sammons, H., Jacqz-Aigrain, E., & Choonara, I. (2011). Ciprofloxacin safety in paediatrics: a systematic review. Archives of Disease in Childhood, 96(9), https://doi.org/10.1136/adc.2010.208843

Objective: To determine the safety of ciprofloxacin in paediatric patients in relation to arthropathy, any other adverse events (AEs) and drug interactions. Methods: A systematic search of MEDLINE, EMBASE, CINAHL, CENTRAL and bibliographies of re... Read More about Ciprofloxacin safety in paediatrics: a systematic review.

Pneumonia and influenza: specific considerations in care homes (2010)
Journal Article
Gordon, A., & Ewan, V. (2010). Pneumonia and influenza: specific considerations in care homes. Reviews in Clinical Gerontology, 20(1), 69-80. https://doi.org/10.1017/S0959259810000043

This review provides an update on current evidence surrounding epidemiology, treatment and prevention of lower respiratory tract infection, with special reference to pneumonia and influenza, in care home residents. The care home sector is growing an... Read More about Pneumonia and influenza: specific considerations in care homes.

Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability (2009)
Journal Article
Allen, C., & Bayraktutan, U. (2009). Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability. Diabetes, Obesity and Metabolism, 11(5), https://doi.org/10.1111/j.1463-1326.2008.00987.x

Aims: Hyperglycaemia (HG), in stroke patients, is associated with worse neurological outcome by compromising endothelial cell function and the blood–brain barrier (BBB) integrity. We have studied the contribution of HG-mediated generation of oxidati... Read More about Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability.

Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells (2008)
Journal Article
Allen, C., & Bayraktutan, U. (2008). Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells. Journal of Molecular and Cellular Cardiology, 45(2),

Angiotensin II (Ang II) and platelet-derived growth factor-BB (PDGF-BB) are associated with excessive cell migration, proliferation and many growth-related diseases. However, whether these agents utilise similar mechanisms to trigger vascular patholo... Read More about Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells.

The bimodal regulation of vascular function by superoxide anion: role of endothelium (2008)
Journal Article
Buket, D., McKeown, P., & Bayraktutan, U. (2008). The bimodal regulation of vascular function by superoxide anion: role of endothelium. Journal of Biochemistry and Molecular Biology, 41(3),

Reactive oxygen species (ROS) are implicated in vascular homeostasis. This study investigated whether O2 .

Multiple sclerosis findings in the spinal cord (2007)
Journal Article
Edwards, L., Tench, C., Gilmore, C., Evangelou, N., & Constantinescu, C. (2007). Multiple sclerosis findings in the spinal cord. Expert Review of Neurotherapeutics, 7(9), 1203-1211. https://doi.org/10.1586/14737175.7.9.1203

Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity (2006)
Journal Article
Mahadevan, V., Campbell, M., McKeown, P., & Bayraktutan, U. (2006). Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity. Cardiovascular Research, 72,

Objective- This study investigated whether differences exist in atherogen-induced migratory behaviors and basal antioxidant enzyme capacity of vascular smooth muscle cells (VSMC) from human coronary (CA) and internal mammary (IMA) arteries. Methods-... Read More about Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity.

Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth (2004)
Journal Article
Bayraktutan, U. (2004). Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth. Journal of Molecular and Cellular Cardiology, 36,

Reactive oxygen species (ROS) including nitric oxide (NO) and superoxide anion (O2-) are associated with cell migration, proliferation and many growth-related diseases. The objective of this study was to determine whether there was a reciprocal relat... Read More about Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth.

High glucose mediates prooxidant and antioxidant enzyme activities in coronary endothelial cells (2004)
Journal Article
Bayraktutan, U., Weidig, P., McMaster, D., & Ulker, S. (2004). High glucose mediates prooxidant and antioxidant enzyme activities in coronary endothelial cells

Objective: Excess levels of free radicals such as nitric oxide (NO) and superoxide anion (O2-)are associated with the pathogenesis of endothelial cell dysfunction in diabetes mellitus. This study was designed to investigate the underlying causes of o... Read More about High glucose mediates prooxidant and antioxidant enzyme activities in coronary endothelial cells.

Antioxidant vitamins C and E ameliorate hyperglycaemia induced oxidative stress in coronary endothelial cells (2004)
Journal Article
Ulker, S., McMaster, D., McKeown, P., & Bayraktutan, U. (2004). Antioxidant vitamins C and E ameliorate hyperglycaemia induced oxidative stress in coronary endothelial cells

Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells (2000)
Journal Article
Bayraktutan, U., Blayney, L., & Shah, A. (2000). Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells

The production of reactive oxygen species (ROS) within endothelial cells may have several effects, including alterations in the activity of paracrine factors, gene expression, apoptosis, and cellular injury. Recent studies indicate that a phagocyte... Read More about Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells.

Care homes, their communities, and resilience in the face of the COVID-19 pandemic: interim findings from a qualitative study
Working Paper
Marshall, F., Gordon, A. L., Gladman, J. R., & Bishop, S. (2020). Care homes, their communities, and resilience in the face of the COVID-19 pandemic: interim findings from a qualitative study

Background: From late February 2020, English care homes rapidly adapted their practices in response to the COVID-19 pandemic. In addition to accommodating new guidelines and policies, staff had to adjust to rapid reconfiguration of services external... Read More about Care homes, their communities, and resilience in the face of the COVID-19 pandemic: interim findings from a qualitative study.

Exploring haemodynamics of haemodialysis using extrema points analysis model
Journal Article
Eldehni, M. T., Odudu, A., & McIntyre, C. W. Exploring haemodynamics of haemodialysis using extrema points analysis model. Theoretical Biology and Medical Modelling, 10, Article 33. https://doi.org/10.1186/1742-4682-10-33

Background: Haemodialysis is a form of renal replacement therapy used to treat patients with end stage renal failure. It is becoming more appreciated that haemodialysis patients exhibit higher rates of multiple end organ damage compared to the gen... Read More about Exploring haemodynamics of haemodialysis using extrema points analysis model.

Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer
Journal Article
Cruickshanks, H., Vafadar-Isfahani, N., Dunican, D., Lee, A., Sproul, D., Lund, J. N., …Tufarelli, C. Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer. Nucleic Acids Research, 41(14), https://doi.org/10.1093/nar/gkt438

LINE-1 retrotransposons are abundant repetitive elements of viral origin, which in normal cells are kept quiescent through epigenetic mechanisms. Activation of LINE-1 occurs frequently in cancer and can enable LINE-1 mobilization but also has re... Read More about Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer.