The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study

Panoutsopoulou, Kalliope; Metrustry, Sarah; Doherty, Sally A.; Laslett, Laura L.; Maciewicz, Rose A.; Hart, Deborah J.; Zhang, Weiya; Muir, Kenneth R.; Wheeler, Margaret; Cooper, Cyrus; Spector, Tim D.; Cicuttini, Flavia M.; Jones, Graeme; Arden, Nigel K.; Doherty, Michael; Zeggini, Eleftheria; Valdes, Ana M

doi:10.1136/annrheumdis-2013-203772

All Outputs (105)

Circulating levels of antioxidant vitamins correlate with better lung function and reduced exposure to ambient pollution (2015)
Journal Article
Menni, C., Metrustry, S., Mohney, R., Beevers, S., Barratt, B., Spector, T., …Valdes, A. (2015). Circulating levels of antioxidant vitamins correlate with better lung function and reduced exposure to ambient pollution. American Journal of Respiratory and Critical Care Medicine, 191(10), https://doi.org/10.1164/rccm.201411-2059LE

An atlas of genetic influences on human blood metabolites (2014)
Journal Article
Shin, S., The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Fauman, E. B., Petersen, A., Krumsiek, J., Santos, R., …Soranzo, N. (2014). An atlas of genetic influences on human blood metabolites. Nature Genetics, 46(6), 543-550. https://doi.org/10.1038/ng.2982

Genome-wide association scans with high-throughput metabolic profiling provide unprecedented insights into how genetic variation influences metabolism and complex disease. Here we report the most comprehensive exploration of genetic loci influencing... Read More about An atlas of genetic influences on human blood metabolites.

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31 (2014)
Journal Article
Styrkarsdottir, U., Thorleifsson, G., Helgadottir, H. T., Bomer, N., Metrustry, S., Bierma-Zeinstra, S., …Stefansson, K. (2014). Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. Nature Genetics, 46(5), 498-502. https://doi.org/10.1038/ng.2957

Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan (2013)
Journal Article
Kuo, C., Grainge, M. J., See, L., Yu, K., Luo, S., Valdes, A. M., …Doherty, M. (2015). Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the Rheumatic Diseases, 74(2), 369-374. https://doi.org/10.1136/annrheumdis-2013-204067

© 2015, BMJ Publishing Group. All rights reserved. Objective: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. Methods: Using data from the Nati... Read More about Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.

The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study (2013)
Journal Article
Panoutsopoulou, K., Metrustry, S., Doherty, S. A., Laslett, L. L., Maciewicz, R. A., Hart, D. J., …Valdes, A. M. (2014). The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study. Annals of the Rheumatic Diseases, 73(12), 2082-2086. https://doi.org/10.1136/annrheumdis-2013-203772

© 2015, BMJ Publishing Group. All rights reserved. Objective: Variation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA). We e... Read More about The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study.