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All Outputs (41)

Calibration of arterial spin labeling data—potential pitfalls in post‐processing (2019)
Journal Article
Pinto, J., Chappell, M. A., Okell, T. W., Mezue, M., Segerdahl, A. R., Tracey, I., …Figueiredo, P. (2020). Calibration of arterial spin labeling data—potential pitfalls in post‐processing. Magnetic Resonance in Medicine, 83(4), 1222-1234. https://doi.org/10.1002/mrm.28000

Purpose To assess the impact of the different post?processing options in the calibration of arterial spin labeling (ASL) data on perfusion quantification and its reproducibility. Theory and Methods Absolute quantification of perfusion measuremen... Read More about Calibration of arterial spin labeling data—potential pitfalls in post‐processing.

Quantification of cerebral perfusion and cerebrovascular reserve using Turbo?QUASAR arterial spin labeling MRI (2019)
Journal Article
Zhao, M. Y., Václavů, L., Petersen, E. T., Biemond, B. J., Sokolska, M. J., Suzuki, Y., …Chappell, M. A. (2020). Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI. Magnetic Resonance in Medicine, 83(2), 731-748. https://doi.org/10.1002/mrm.27956

Purpose To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo?QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post... Read More about Quantification of cerebral perfusion and cerebrovascular reserve using Turbo?QUASAR arterial spin labeling MRI.

Robust estimation of quantitative perfusion from multi?phase pseudo?continuous arterial spin labeling (2019)
Journal Article
Msayib, Y., Craig, M., Simard, M. A., Larkin, J. R., Shin, D. D., Liu, T. T., …Chappell, M. A. (2020). Robust estimation of quantitative perfusion from multi‐phase pseudo‐continuous arterial spin labeling. Magnetic Resonance in Medicine, 83(3), 815-829. https://doi.org/10.1002/mrm.27965

Purpose Multi‐phase PCASL has been proposed as a means to achieve accurate perfusion quantification that is robust to imperfect shim in the labeling plane. However, there exists a bias in the estimation process that is a function of noise in the dat... Read More about Robust estimation of quantitative perfusion from multi?phase pseudo?continuous arterial spin labeling.

Model-based Bayesian inference of brain oxygenation using quantitative BOLD (2019)
Journal Article
Cherukara, M. T., Stone, A. J., Chappell, M. A., & Blockley, N. P. (2019). Model-based Bayesian inference of brain oxygenation using quantitative BOLD. NeuroImage, 202, Article 116106. https://doi.org/10.1016/j.neuroimage.2019.116106

© 2019 The Authors Streamlined Quantitative BOLD (sqBOLD) is an MR technique that can non-invasively measure physiological parameters including Oxygen Extraction Fraction (OEF) and deoxygenated blood volume (DBV) in the brain. Current sqBOLD methodol... Read More about Model-based Bayesian inference of brain oxygenation using quantitative BOLD.

ICA-based denoising for ASL perfusion imaging (2019)
Journal Article
Carone, D., Harston, G., Garrard, J., De Angeli, F., Griffanti, L., Okell, T., …Kennedy, J. (2019). ICA-based denoising for ASL perfusion imaging. NeuroImage, 200, 363-372. https://doi.org/10.1016/j.neuroimage.2019.07.002

Arterial Spin Labelling (ASL) imaging derives a perfusion image by tracing the accumulation of magnetically labeled blood water in the brain. As the image generated has an intrinsically low signal to noise ratio (SNR), multiple measurements are routi... Read More about ICA-based denoising for ASL perfusion imaging.

Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages (2019)
Journal Article
Suri, S., Topiwala, A., Chappell, M. A., Okell, T. W., Zsoldos, E., Singh-Manoux, A., …Ebmeier, K. P. (2019). Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages. JAMA Network Open, 2(6), Article e195776. https://doi.org/10.1001/jamanetworkopen.2019.5776

© 2019 AMA. All rights reserved. Importance: Poor cardiovascular health is an established risk factor for dementia, but little is known about its association with brain physiology in older adults. Objective: To examine the association of cardiovascul... Read More about Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages.

High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging (2019)
Journal Article
van der Plas, M. C., Teeuwisse, W. M., Schmid, S., Chappell, M., & van Osch, M. J. (2019). High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging. Magnetic Resonance in Medicine, 81(6), 3734-3744. https://doi.org/10.1002/mrm.27692

Purpose The goal of this study was to achieve high temporal resolution, multi?time point pseudo?continuous arterial spin labeling (pCASL) MRI in a time?efficient manner, while maintaining whole?brain coverage. Methods A Hadamard 8?matrix was use... Read More about High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging.

Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging (2019)
Journal Article
Ray, K. J., Simard, M. A., Larkin, J. R., Coates, J., Kinchesh, P., Smart, S. C., …Sibson, N. R. (2019). Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging. Cancer Research, 79(7), 1343-1352. https://doi.org/10.1158/0008-5472.can-18-2168

Abnormal pH is a common feature of malignant tumors and has been associated clinically with suboptimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) holds promise as a means to noninvasively measure tumor pH, yet multiple facto... Read More about Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging.

A general framework for optimizing arterial spin labeling MRI experiments (2018)
Journal Article
Woods, J. G., Chappell, M. A., & Okell, T. W. (2019). A general framework for optimizing arterial spin labeling MRI experiments. Magnetic Resonance in Medicine, 81(4), 2474-2488. https://doi.org/10.1002/mrm.27580

Purpose Arterial spin labeling (ASL) MRI is a non‐invasive perfusion imaging technique that is inherently SNR limited, so scan protocols ideally need to be rigorously optimized to provide the most accurate measurements. A general framework is presen... Read More about A general framework for optimizing arterial spin labeling MRI experiments.

Assessing Reliability of Myocardial Blood Flow After Motion Correction With Dynamic PET Using a Bayesian Framework (2018)
Journal Article
Saillant, A., Armstrong, I., Shah, V., Zuehlsdorff, S., Hayden, C., Declerck, J., …Chappell, M. A. (2019). Assessing Reliability of Myocardial Blood Flow After Motion Correction With Dynamic PET Using a Bayesian Framework. IEEE Transactions on Medical Imaging, 38(5), 1216-1226. https://doi.org/10.1109/tmi.2018.2881992

The estimation of myocardial blood flow (MBF) in dynamic PET can be biased by many different processes. A major source of error, particularly in clinical applications, is patient motion. Patient motion, or gross motion, creates displacements between... Read More about Assessing Reliability of Myocardial Blood Flow After Motion Correction With Dynamic PET Using a Bayesian Framework.

Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice (2018)
Journal Article
Buck, J., Larkin, J. R., Simard, M. A., Khrapitchev, A. A., Chappell, M. A., & Sibson, N. R. (2018). Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice. Contrast Media and Molecular Imaging, 2018, 1-11. https://doi.org/10.1155/2018/4580919

Brain and tumour blood flow can be measured noninvasively using arterial spin labelling (ASL) magnetic resonance imaging (MRI), but reliable quantification in mouse models remains difficult. Pseudocontinuous ASL (pCASL) is recommended as the clinical... Read More about Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice.

Using arterial spin labelling to investigate spontaneous and evoked ongoing musculoskeletal pain (2018)
Other
Wartolowska, K. A., Bulte, D. P., Chappell, M. A., Jenkinson, M., Okell, T. W., Webster, M. A., & Carr, A. J. (2018). Using arterial spin labelling to investigate spontaneous and evoked ongoing musculoskeletal pain

Clinical pain is difficult to study using standard Blood Oxy-genation Level Dependent (BOLD) magnetic resonance imaging because it is often ongoing and, if evoked, it is associated with stimulus-correlated motion. Arterial spin labelling (ASL) offers... Read More about Using arterial spin labelling to investigate spontaneous and evoked ongoing musculoskeletal pain.

A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth (2017)
Journal Article
Roque, T., Risser, L., Kersemans, V., Smart, S., Allen, D., Kinchesh, P., …Chappell, M. A. (2018). A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth. IEEE Transactions on Medical Imaging, 37(3), 724-732. https://doi.org/10.1109/tmi.2017.2779811

Predicting tumor growth and its response to therapy remains a major challenge in cancer research and strongly relies on tumor growth models. In this paper, we introduce, calibrate, and verify a novel image-driven reaction-diffusion model of avascular... Read More about A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth.

A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI (2017)
Journal Article
Zhao, M. Y., Mezue, M., Segerdahl, A. R., Okell, T. W., Tracey, I., Xiao, Y., & Chappell, M. A. (2017). A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI. NeuroImage, 162, 384-397. https://doi.org/10.1016/j.neuroimage.2017.08.072

Arterial spin labeling (ASL) MRI is a non-invasive technique for the quantification of cerebral perfusion, and pseudo-continuous arterial spin labeling (PCASL) has been recommended as the standard implementation by a recent consensus of the community... Read More about A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI.

Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease (2017)
Journal Article
Hartkamp, N. S., Petersen, E. T., Chappell, M. A., Okell, T. W., Uyttenboogaart, M., Zeebregts, C. J., & Bokkers, R. P. (2018). Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease. Journal of Cerebral Blood Flow and Metabolism, 38(11), 2021-2032. https://doi.org/10.1177/0271678x17724027

Collateral blood flow plays a pivotal role in steno-occlusive internal carotid artery (ICA) disease to prevent irreversible ischaemic damage. Our aim was to investigate the effect of carotid artery disease upon cerebral perfusion and cerebrovascular... Read More about Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease.

Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience (2017)
Journal Article
Garcia, M., Okell, T., Gloor, M., Chappell, M., Jezzard, P., Bieri, O., & Byrne, J. (2017). Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience. American Journal of Neuroradiology, 38(4), 735-739. https://doi.org/10.3174/ajnr.a5091

The different results from flat panel detector CT in various pathologies have provoked some discussion. Our aim was to assess the role of flat panel detector CT in brain arteriovenous malformations, which has not yet been assessed. Five patients with... Read More about Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience.