All Outputs (1578)

‘Involuntary exit for personal reasons’ – A gendered critique of the business exit decision (2024)
Journal Article

Women are more likely to exit from entrepreneurship for personal reasons; such exits are deemed uneventful and voluntary. We critically evaluate such assumptions by adopting a gendered critique to unpack the nature of such personal reasons arguing th... Read More about ‘Involuntary exit for personal reasons’ – A gendered critique of the business exit decision.

Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial (2024)
Journal Article

Background: Dupuytren’s contractures (DC) are fibrous cords under the skin of the hand that cause one or more fingers to curl gradually and irreversibly towards the palm. These contractures are usually painless but can cause a loss of hand function.... Read More about Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial.

Shared adversaries in the Anglo-American Special Relationship: from the Cold War to contemporary threats (2024)
Journal Article

The Anglo-American Special Relationship has been at its most vibrant when the two countries have shared a common adversary. The Cold War confrontation with the Soviet Union and its Warsaw Pact allies, and then Islamist terrorism during the ‘War on Te... Read More about Shared adversaries in the Anglo-American Special Relationship: from the Cold War to contemporary threats.

Experience of CBT in adults with ADHD: a mixed methods study (2024)
Journal Article

Introduction: The National Institute for Health and Care Excellence (NICE) recommends Cognitive Behavioural therapy (CBT) as the psychotherapeutic treatment of choice for adults with Attention Deficit Hyperactivity Disorder (ADHD) in the UK. However,... Read More about Experience of CBT in adults with ADHD: a mixed methods study.

Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics (2024)
Journal Article

Artificial intelligence for small molecule anticancer drug discovery (2024)
Journal Article

Introduction: The transition from conventional cytotoxic chemotherapy to targeted cancer therapy with small-molecule anticancer drugs has enhanced treatment outcomes. This approach, which now dominates cancer treatment, has several advantages. Despit... Read More about Artificial intelligence for small molecule anticancer drug discovery.

Beyond Trees: Calculating Graph-Based Compilers (2024)
Journal Article

Bahr and Hutton recently developed an approach to compiler calculation that allows a wide range of compilers to be derived from specifications of their correctness. However, a limitation of the approach is that it results in compilers that produce tr... Read More about Beyond Trees: Calculating Graph-Based Compilers.

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article

Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventin... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

A mixed methods investigation into GP attitudes and experiences of using social prescribing in their practice (2024)
Journal Article

Aim Social prescribing (SP) enables clinicians to signpost patients to non-medical services in the community in order to support their psycho-social needs. SP has been promoted as a positive service delivery model for primary and community care; how... Read More about A mixed methods investigation into GP attitudes and experiences of using social prescribing in their practice.

Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells (2024)
Journal Article

Soluble factors in the secretome of Acanthamoeba castellanii play crucial roles in the pathogenesis of Acanthamoeba keratitis (AK). Investigating the pathological effects of A. castellanii-derived conditioned medium (ACCM) on ocular cells can provide... Read More about Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells.

A single-cell atlas of pig gastrulation as a resource for comparative embryology (2024)
Journal Article

Cell-fate decisions during mammalian gastrulation are poorly understood outside of rodent embryos. The embryonic disc of pig embryos mirrors humans, making them a useful proxy for studying gastrulation. Here we present a single-cell transcriptomic at... Read More about A single-cell atlas of pig gastrulation as a resource for comparative embryology.

South Georgia marine productivity over the past 15 ka and implications for glacial evolution (2024)
Journal Article

The subantarctic islands of South Georgia are located in the Southern Ocean, and they may be sensitive to future climate warming. However, due to a lack of well-dated subantarctic palaeoclimate archives, there is still uncertainty about South Georgia... Read More about South Georgia marine productivity over the past 15 ka and implications for glacial evolution.

Friction and heat partition coefficients in incremental sheet forming process (2024)
Journal Article

To understand the thermo-mechanical behaviour in incremental sheet forming (ISF), it is important to precisely determine the interfacial and thermal-relevant parameters including coefficient of friction (COF) and heat partition coefficient (HPC), and... Read More about Friction and heat partition coefficients in incremental sheet forming process.

Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire (2024)
Journal Article

Background Neuropathic-like pain, fatigue, cognitive difficulty, catastrophizing, anxiety, sleep disturbance, depression and widespread pain associate with a single factor in people with knee pain. We report the Central Aspects of Pain questionnai... Read More about Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire.

Parenting in a changing climate: the relationship between talking to children aged 5-11 about climate change, family eco-behaviours and climate change anxiety (2024)
Journal Article

Climate change has a substantial impact on human health and the increased symptoms of climate change anxiety have led to a global call for action. However, data exploring the relationship between climate change, mental health, and individuals with pa... Read More about Parenting in a changing climate: the relationship between talking to children aged 5-11 about climate change, family eco-behaviours and climate change anxiety.

Evaluation of factors predicting tinnitus outcomes following cochlear implantation: Protocol for a prospective quasi-experimental study (2024)
Journal Article

Cochlear implantation is an effective intervention to restore useful aspects of hearing function in adults with severe-to-profound hearing loss. Tinnitus, the perception of sound in the absence of an external source, is common in people with severe-t... Read More about Evaluation of factors predicting tinnitus outcomes following cochlear implantation: Protocol for a prospective quasi-experimental study.

The importance of 3D fibre architecture in cancer and implications for biomaterial model design (2024)
Journal Article

The need for improved prediction of clinical response is driving the development of cancer models with enhanced physiological relevance. A new concept of ‘precision biomaterials’ is emerging, encompassing patient-mimetic biomaterial models that seek... Read More about The importance of 3D fibre architecture in cancer and implications for biomaterial model design.

Policy Brief: Neurodiversity in the workplace (2024)
Report

Although neurodiversity is relatively common (1 in 7 people in the UK), workplaces are rarely designed with neurodiversity in mind. Neurodivergent people report additional challenges with securing and maintaining a job because the workplace environm... Read More about Policy Brief: Neurodiversity in the workplace.

MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1 (2024)
Journal Article

In animals, microRNA (miRNA) biogenesis begins with cotranscriptional cleavage of the primary (pri-)miRNA by the Microprocessor complex. Cotranscriptional splicing has been shown to influence Microprocessor cleavage when miRNAs are hosted in introns... Read More about MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1.

Policy Brief: Access to care for neurodiversity - ADHD and Tourette Syndrome (2024)
Report

Around 15-20% of the population is neurodivergent. Despite this, access to diagnoses and care for neurodivergent people is problematic and there is inconsistent support across the UK. Research at the University of Nottingham focuses on the impor... Read More about Policy Brief: Access to care for neurodiversity - ADHD and Tourette Syndrome.