All Outputs (3438)

MRI assessment of cerebral perfusion in clinical trials (2023)
Journal Article
Wang, X., Bishop, C., O'Callaghan, J., Gayhoor, A., Albani, J., Theriault, W., …Becerra, L. (2023). MRI assessment of cerebral perfusion in clinical trials. Drug Discovery Today, 28(4), Article 103506. https://doi.org/10.1016/j.drudis.2023.103506

Neurodegenerative mechanisms affect the brain through a variety of processes that are reflected as changes in brain structure and physiology. Although some biomarkers for these changes are well established, others are at different stages of developme... Read More about MRI assessment of cerebral perfusion in clinical trials.

The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations (2023)
Journal Article
Musa, A., Ihmaid, S. K., Hughes, D. L., Said, M. A., Abulkhair, H. S., El-Ghorab, A. H., Abdelgawad, M. A., Shalaby, K., Shaker, M. E., Alharbi, K. S., Alotaibi, N. H., Kays, D. L., Taylor, L. J., Parambi, D. G. T., Alzarea, S. I., Al-Karmalawy, A. A., Ahmed, H. E., & El-Agrody, A. M. (2023). The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations. Journal of Biomolecular Structure and Dynamics, 41(21), 12411-12425. https://doi.org/10.1080/07391102.2023.2167000

Treatment options for the management of breast cancer are still inadequate. This inadequacy is attributed to the lack of effective targeted medications, often resulting in the recurrence of metastatic disorders. Cumulative evidence suggests that epid... Read More about The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations.

Presentism and representation: saying it without words (2023)
Journal Article
Baron, S., Miller, K., & Tallant, J. (2023). Presentism and representation: saying it without words. Synthese, 201(2), Article 36. https://doi.org/10.1007/s11229-022-03987-2

The Triviality Argument against presentism maintains that we should reject presentism because there is no way to define the view that is not either trivially true or obviously false. We suggest that this style of argument over-emphasises purely lingu... Read More about Presentism and representation: saying it without words.

Stochastic Approach to Modelling Emissions of Multiple Power Electronic Converters (2023)
Presentation / Conference Contribution
Ballukja, E., Aitbar, I., Niewiadomski, K., Thomas, D. W., Sumner, M., & Smolenski, R. (2023). Stochastic Approach to Modelling Emissions of Multiple Power Electronic Converters. In 2023 IEEE 7th Global Electromagnetic Compatibility Conference (GEMCCON). https://doi.org/10.1109/gemccon57842.2023.10078210

The aim of this paper is to describe the effects of time delays (Δt) between the switching of several converters on the statistical quantification of the common mode current caused by a multiple converters set-up. To this end, the time delays are con... Read More about Stochastic Approach to Modelling Emissions of Multiple Power Electronic Converters.

Comparison of Great Britain and Ukraine railway systems based on their EMC capability and electrification systems (2023)
Presentation / Conference Contribution
Adhena, H. H., Serdiuk, T., Thomas, D., & Greedy, S. (2023). Comparison of Great Britain and Ukraine railway systems based on their EMC capability and electrification systems. In 2023 IEEE 7th Global Electromagnetic Compatibility Conference (GEMCCon) : Merusaka Nusa Dua, Bali 19 - 20 January 2023 (35-36). https://doi.org/10.1109/GEMCCON57842.2023.10078193

In this paper, a comparison based on electromagnetic compatibility capability, electromagnetic interference susceptibility, signalling, and electrification systems of Great Britain and Ukraine's railway systems will be analyzed.

Industry Insights and Post Pandemic Practices for Entrepreneurship and Innovation in Leisure (2023)
Journal Article
Shipway, R., Mosey, S., & Symons, C. (2023). Industry Insights and Post Pandemic Practices for Entrepreneurship and Innovation in Leisure. Leisure Studies, 42(6), 956-970. https://doi.org/10.1080/02614367.2022.2157467

This article explores how leisure organisations developed entrepreneurial practices to enable innovation for the post covid-19 pandemic era. Whilst entrepreneurship and innovation has been the subject of academic scrutiny in mainstream sport, there i... Read More about Industry Insights and Post Pandemic Practices for Entrepreneurship and Innovation in Leisure.

Exploring young voter engagement and journey mapping across political events (2023)
Journal Article
Poorrezaei, M., Pich, C., Armannsdottir, G., Branco-Illodo, I., & Harvey, J. (2023). Exploring young voter engagement and journey mapping across political events. International Journal of Market Research, 65(5), 532-565. https://doi.org/10.1177/14707853231151890

This interdisciplinary study aims to explore the lived experiences and engagement of young voters from a customer journey perspective. To achieve this, the present study investigates voter engagement journey with various political events (2015 UK Gen... Read More about Exploring young voter engagement and journey mapping across political events.

Precarious employment and workplace health outcomes in Britain (2023)
Journal Article
Haile, G. A. (2023). Precarious employment and workplace health outcomes in Britain. Social Science and Medicine, 320, Article 115694. https://doi.org/10.1016/j.socscimed.2023.115694

Rationale: The world of work is changing rapidly, and precarious employment is becoming more prevalent in Britain and elsewhere, particularly since the 2008 financial crisis. This is despite the evidence linking employment precarity to adverse health... Read More about Precarious employment and workplace health outcomes in Britain.

Computational study of free surface film flow and subsequent disintegration of a sheet and ligaments into droplets from a rotary disk atomizer (2023)
Journal Article
Singh, K., Ambrose, S., Jefferson-Loveday, R., Nicoli, A., & Mouvanal, S. (2023). Computational study of free surface film flow and subsequent disintegration of a sheet and ligaments into droplets from a rotary disk atomizer. Engineering Applications of Computational Fluid Mechanics, 17(1), Article 2162971. https://doi.org/10.1080/19942060.2022.2162971

In the present study, a computational methodology based on computational fluid dynamics (CFD) is developed to investigate free surface film flow and its subsequent disintegration on a rotary disk atomizer. The present study provides an insight into e... Read More about Computational study of free surface film flow and subsequent disintegration of a sheet and ligaments into droplets from a rotary disk atomizer.

Enslaved by their Own Government: Indefinite National Service in Eritrea (2023)
Book Chapter
Palacios-Arapiles, S. (2023). Enslaved by their Own Government: Indefinite National Service in Eritrea. In M. van Reisen, M. Mawere, K. Smits, & M. Wirtz (Eds.), Enslaved: Trapped and Trafficked in Digital Black Holes: Human Trafficking Trajectories to Libya (195-254). Langaa RPCID

Estimating the energy requirements for long term memory formation (2023)
Preprint / Working Paper
Girard, M., Jiang, J., & van Rossum, M. C. Estimating the energy requirements for long term memory formation

Brains consume metabolic energy to process information, but also to store memories. The energy required for memory formation can be substantial, for instance in fruit flies memory formation leads to a shorter lifespan upon subsequent starvation (Mery... Read More about Estimating the energy requirements for long term memory formation.

Analysis of the response of a roadway bridge under extreme flooding-related events: Scour and debris-loading (2023)
Journal Article
Kosič, M., Prendergast, L., & Anžlin, A. (2023). Analysis of the response of a roadway bridge under extreme flooding-related events: Scour and debris-loading. Engineering Structures, 279, Article 115607. https://doi.org/10.1016/j.engstruct.2023.115607

Hydraulic actions on bridges are a leading cause of failure, especially due to the occurrence of scour erosion. Due to climate change, flooding and scour risks are exacerbating for bridges worldwide, leading to a significant stress burden on asset ma... Read More about Analysis of the response of a roadway bridge under extreme flooding-related events: Scour and debris-loading.

What affected UK adults’ adherence to medicines during the COVID-19 pandemic? Cross-sectional survey in a representative sample of people with long-term conditions (2023)
Journal Article
Penner, L. S., Armitage, C. J., Thornley, T., Whelan, P., Chuter, A., Allen, T., & Elliott, R. A. (2024). What affected UK adults’ adherence to medicines during the COVID-19 pandemic? Cross-sectional survey in a representative sample of people with long-term conditions. Journal of Public Health, 32(2), 325-338. https://doi.org/10.1007/s10389-022-01813-0

Aim
Medicines non-adherence is associated with poorer outcomes and higher costs. COVID-19 affected access to healthcare, with increased reliance on remote methods, including medicines supply. This study aimed to identify what affected people’s adher... Read More about What affected UK adults’ adherence to medicines during the COVID-19 pandemic? Cross-sectional survey in a representative sample of people with long-term conditions.

"More Than a cliché": Experiencing Hybrid Gifting in the Wild (2023)
Journal Article
Spence, J., Koleva, B., Benford, S., Darzentas, D., Flintham, M., Glover, K., …Thorn, E. C. (2023). "More Than a cliché": Experiencing Hybrid Gifting in the Wild. ACM Transactions on Computer-Human Interaction, 30(4), Article 55. https://doi.org/10.1145/3577015

Gifting is socially and economically important. Studies of gifting physical objects have revealed motivations, values, and the tensions between them, while HCI research has revealed weaknesses of digital gifting and explored possibilities of hybrid g... Read More about "More Than a cliché": Experiencing Hybrid Gifting in the Wild.

The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human β1-Adrenoceptor (2023)
Journal Article
Lim, V. J. Y., Proudman, R. G. W., Monteleone, S., Kolb, P., & Baker, J. G. (2023). The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human β1-Adrenoceptor. Molecular Pharmacology, 103(2), 89-99. https://doi.org/10.1124/molpharm.122.000583

Known off-target interactions frequently cause predictable drug side-effects (e.g., β1-antagonists used for heart disease, risk β2-mediated bronchospasm). Computer-aided drug design would improve if the structural basis of existing drug selectivity w... Read More about The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human β1-Adrenoceptor.

Expression, assessment and significance of Ki67 expression in breast cancer: an update (2023)
Journal Article
Lashen, A. G., Toss, M. S., Ghannam, S. F., Makhlouf, S., Green, A., Mongan, N. P., & Rakha, E. (2023). Expression, assessment and significance of Ki67 expression in breast cancer: an update. Journal of Clinical Pathology, 76(6), Article 357-364. https://doi.org/10.1136/jcp-2022-208731

Ki67 expression is one of the most important and cost-effective surrogate markers to assess for tumour cell proliferation in breast cancer (BC). The Ki67 labelling index has prognostic and predictive value in patients with early-stage BC, particularl... Read More about Expression, assessment and significance of Ki67 expression in breast cancer: an update.

Stacking sequence optimisation of an aircraft wing skin (2023)
Journal Article
Ntourmas, G., Glock, F., Deinert, S., Daoud, F., Schuhmacher, G., Chronopoulos, D., …Ninić, J. (2023). Stacking sequence optimisation of an aircraft wing skin. Structural and Multidisciplinary Optimization, 66(2), Article 31. https://doi.org/10.1007/s00158-022-03483-8

This paper demonstrates a stacking sequence optimisation process of a composite aircraft wing skin. A two-stage approach is employed to satisfy all sizing requirements of this industrial sized, medium altitude, long endurance drone. In the first stag... Read More about Stacking sequence optimisation of an aircraft wing skin.

Improving Orthologous Signal and Model Fit in Datasets Addressing the Root of the Animal Phylogeny (2023)
Journal Article
McCarthy, C. G., Mulhair, P. O., Siu-Ting, K., Creevey, C. J., & O’Connell, M. J. (2023). Improving Orthologous Signal and Model Fit in Datasets Addressing the Root of the Animal Phylogeny. Molecular Biology and Evolution, 40(1), Article msac276. https://doi.org/10.1093/molbev/msac276

There is conflicting evidence as to whether Porifera (sponges) or Ctenophora (comb jellies) comprise the root of the animal phylogeny. Support for either a Porifera-sister or Ctenophore-sister tree has been extensively examined in the context of mode... Read More about Improving Orthologous Signal and Model Fit in Datasets Addressing the Root of the Animal Phylogeny.

The natural pattern of birth timing and gestational age in the U.S. compared to England, and the Netherlands (2023)
Journal Article
Declercq, E., Wolterink, A., Rowe, R., de Jonge, A., De Vries, R., Nieuwenhuijze, M., …Shah, N. (2023). The natural pattern of birth timing and gestational age in the U.S. compared to England, and the Netherlands. PLoS ONE, 18(1), Article e0278856. https://doi.org/10.1371/journal.pone.0278856

Objective To examine cross-national differences in gestational age over time in the U.S. and across three wealthy countries in 2020 as well as examine patterns of birth timing by hour of the day in home and spontaneous vaginal hospital births in the... Read More about The natural pattern of birth timing and gestational age in the U.S. compared to England, and the Netherlands.

The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up (2023)
Journal Article
Lashen, A. G., Toss, M. S., Mongan, N. P., Green, A. R., & Rakha, E. A. (2023). The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up. Cancer, 129(8), 1183-1194. https://doi.org/10.1002/cncr.34655

Background: The routine assessment of progesterone receptor (PR) expression in breast cancer (BC) remains controversial. This study aimed to evaluate the role of PR expression in luminal BC, with emphasis on the definition of positivity and its progn... Read More about The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up.