Enantioselective “clip-cycle” synthesis of di-, tri- and spiro-substituted tetrahydropyrans
(2022)
Journal Article
Alomari, K., Sai Pavan Chakravarthy, N., Duchadeau, B., Ermanis, K., & Clarke, P. A. (2022). Enantioselective “clip-cycle” synthesis of di-, tri- and spiro-substituted tetrahydropyrans. Organic and Biomolecular Chemistry, 20(6), 1181-1185. https://doi.org/10.1039/d2ob00023g
ω-Unsaturated alcohols were “clipped” via alkene metathesis to a thioester activating group, which was followed by a chiral phosphoric acid catalyzed intramolecular oxa-Michael cyclization to yield tetrahydropyrans and spiro-tetrahydropyrans with exc... Read More about Enantioselective “clip-cycle” synthesis of di-, tri- and spiro-substituted tetrahydropyrans.