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Photoacoustic response optimization of gold nanorods in the near-infrared region

Sun, Jian-Ping; Ren, Ya-Tao; Wei, Kai; He, Ming-Jian; Gao, Bao-Hai; Qi, Hong


Jian-Ping Sun

Ya-Tao Ren

Kai Wei

Ming-Jian He

Bao-Hai Gao

Hong Qi



Photoacoustic imaging (PAI) combines the advantage of optical and ultrasonic imaging, which has a high signal-to-noise ratio, and spatial resolution. To further improve the performance of PAI, gold nanorods can be utilized as exogenous contrast agents, and their size can be controlled. The size change of gold nanorods will change their absorption and heat transfer characteristics, and then affect their photoacoustic characteristics. Therefore, in the present work, the influences of absorption characteristics (absorption cross section and volume absorption coefficient) and heat transfer characteristics (specific surface area) of gold nanorods on photoacoustic response are studied by FDTD (FDTD Solutions, Lumerical) and FEM (Comsol Multiphysics). Results show that the increase of specific surface area will enhance the thermal coupling between gold nanorods and water, so as to improve the heat transfer and produce different photothermal responses without significantly affecting the photoacoustic quantum yield (As the specific surface area increases by about 10 times, the temperature increases by about 12 times, while the photoacoustic quantum yield increases by about 24%). On the contrary, absorption characteristics are decisive factors for both photothermal and photoacoustic responses. Therefore, in terms of improving photoacoustic quantum yield, when the size of gold nanorods changes, more attention should be paid to the improvement of the absorption characteristics rather than the specific surface area. In addition, increasing the specific surface area can significantly improve the photostability of gold nanorods, which is very important for practical applications.


Sun, J., Ren, Y., Wei, K., He, M., Gao, B., & Qi, H. (2022). Photoacoustic response optimization of gold nanorods in the near-infrared region. Results in Physics, 34, Article 105209.

Journal Article Type Article
Acceptance Date Jan 6, 2022
Online Publication Date Jan 12, 2022
Publication Date 2022-03
Deposit Date Feb 1, 2023
Publicly Available Date Feb 2, 2023
Journal Results in Physics
Electronic ISSN 2211-3797
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 34
Article Number 105209
Keywords General Physics and Astronomy
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Additional Information This article is maintained by: Elsevier; Article Title: Photoacoustic response optimization of gold nanorods in the near-infrared region; Journal Title: Results in Physics; CrossRef DOI link to publisher maintained version:; Content Type: article; Copyright: © 2022 The Author(s). Published by Elsevier B.V.


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© 2022 The Author(s). Published by Elsevier B.V.<br /> This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.

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