All Outputs (3)

Functional modulation of PTH1R activation and signaling by RAMP2 (2022)
Journal Article
Nemec, K., Schihada, H., Kleinau, G., Zabel, U., Grushevskyi, E. O., Scheerer, P., …Maiellaro, I. (2022). Functional modulation of PTH1R activation and signaling by RAMP2. Proceedings of the National Academy of Sciences, 119(32), Article e2122037119. https://doi.org/10.1073/pnas.2122037119

Receptor-activity-modifying proteins (RAMPs) are ubiquitously expressed membrane proteins that associate with different G protein-coupled receptors (GPCRs), including the parathyroid hormone 1 receptor (PTH1R), a class B GPCR and an important modulat... Read More about Functional modulation of PTH1R activation and signaling by RAMP2.

Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling (2022)
Journal Article
Anton, S. E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., …Bock, A. (2022). Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell, 185(7), 1130-1142.e11. https://doi.org/10.1016/j.cell.2022.02.011

G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular functions. Cells express many different GPCRs, but all these GPCRs signal to only a few second messengers such as cAMP. It is largely unknown how cells distinguish... Read More about Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.

In Vivo cAMP Dynamics in Drosophila Larval Neurons (2022)
Book Chapter
Maiellaro, I. (2022). In Vivo cAMP Dynamics in Drosophila Larval Neurons. In M. Zaccolo (Ed.), cAMP Signaling: Methods and Protocols (181-194). New York: Humana Press. https://doi.org/10.1007/978-1-0716-2245-2_11

Cyclic adenosine monophosphate (cAMP) is a universal second messenger that mediates a myriad of cell functions across all kingdoms of life. The ability to monitor intracellular changes of cAMP concentration in living cells using FRET-based biosensors... Read More about In Vivo cAMP Dynamics in Drosophila Larval Neurons.