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In Vitro Growth- and Encystation-Inhibitory Efficacies of Matcha Green Tea and Epigallocatechin Gallate Against Acanthameoba Castellanii (2020)
Journal Article
Dickson, A., Cooper, E., Fakae, L. B., Wang, B., Chan, K. L. A., & Elsheikha, H. M. (2020). In Vitro Growth- and Encystation-Inhibitory Efficacies of Matcha Green Tea and Epigallocatechin Gallate Against Acanthameoba Castellanii. Pathogens, 9(9), Article 763. https://doi.org/10.3390/pathogens9090763

We examined the inhibitory effect of matcha green tea (Camellia sinensis) and epigallocatechin gallate (EGCg; the most abundant catechin in tea) on the vegetative growth and encystation of Acanthamoeba castellanii T4 genotype. The sulforhodamine B (S... Read More about In Vitro Growth- and Encystation-Inhibitory Efficacies of Matcha Green Tea and Epigallocatechin Gallate Against Acanthameoba Castellanii.

SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells (2020)
Journal Article
Kim, J. Y., Bai, Y., Jayne, L. A., Abdulkader, F., Gandhi, M., Perreau, T., …Pabla, N. S. (2020). SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells. Journal of Biological Chemistry, 295(48), 16328-16341. https://doi.org/10.1074/jbc.RA120.015110

© 2020 Kim et al. Acute kidney injury (AKI) is a common clinical condition associated with diverse etiologies and abrupt loss of renal function. In patients with sepsis, rhabdomyolysis, cancer, and cardiovascular disorders, the underlying disease or... Read More about SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.

Nematocidal effects of a coriander essential oil and five pure principles on the infective larvae of major ovine gastrointestinal nematodes in vitro (2020)
Journal Article
Helal, M. A., Abdel-Gawad, A. M., Kandil, O. M., Khalifa, M. M. E., Cave, G. W. V., Morrison, A. A., …Elsheikha, H. M. (2020). Nematocidal effects of a coriander essential oil and five pure principles on the infective larvae of major ovine gastrointestinal nematodes in vitro. Pathogens, 9(9), 1-17. https://doi.org/10.3390/pathogens9090740

The anthelmintic effects of extracted coriander oil and five pure essential oil constituents (geraniol, geranyl acetate, eugenol, methyl iso-eugenol, and linalool) were tested, using larval motility assay, on the third-stage larvae (L3s) of Haemonchu... Read More about Nematocidal effects of a coriander essential oil and five pure principles on the infective larvae of major ovine gastrointestinal nematodes in vitro.

Complete genome sequence of Streptococcus agalactiae strain 01173, isolated from Kuwaiti wild fish (2020)
Journal Article
Santi, M., Egan, S. A., Leigh, J. A., Verner-Jeffreys, D. W., & Blanchard, A. M. (2020). Complete genome sequence of Streptococcus agalactiae strain 01173, isolated from Kuwaiti wild fish. Microbiology Resource Announcements, 9(36), https://doi.org/10.1128/MRA.00674-20

© 2020 Santi et al. Here, we report the complete genome of piscine Streptococcus agalactiae 01173 serotype Ia, which was generated using long-read sequencing technology. The bacteria were isolated from wild fish displaying signs of streptococcosis, f... Read More about Complete genome sequence of Streptococcus agalactiae strain 01173, isolated from Kuwaiti wild fish.

Structural, functional, and metabolic alterations in human cerebrovascular endothelial cells during toxoplasma gondii infection and amelioration by verapamil in vitro (2020)
Journal Article
Al-Sandaqchi, A. T., Marsh, V., Williams, H. E. L., Stevenson, C. W., & Elsheikha, H. M. (2020). Structural, functional, and metabolic alterations in human cerebrovascular endothelial cells during toxoplasma gondii infection and amelioration by verapamil in vitro. Microorganisms, 8(9), Article 1386. https://doi.org/10.3390/microorganisms8091386

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Toxoplasma gondii (T. gondii), the causative agent of toxoplasmosis, is a frequent cause of brain infection. Despite its known ability to invade the brain, there is still a dire need to better... Read More about Structural, functional, and metabolic alterations in human cerebrovascular endothelial cells during toxoplasma gondii infection and amelioration by verapamil in vitro.

Cytosine arabinoside constant rate infusion without subsequent subcutaneous injections for the treatment of dogs with meningoencephalomyelitis of unknown origin (2020)
Journal Article
Stee, K., Broeckx, B. J. G., Targett, M., Gomes, S. A., & Lowrie, M. (2020). Cytosine arabinoside constant rate infusion without subsequent subcutaneous injections for the treatment of dogs with meningoencephalomyelitis of unknown origin. Veterinary Record, 187(11), e98-e98. https://doi.org/10.1136/vr.106019

Background The administration of cytosine arabinoside (CA) by continuous rate infusion (CRI) at the time of diagnosis has been shown to improve the 3-month survival of dogs diagnosed with meningoencephalomyelitis of unknown origin (MUO), compared to... Read More about Cytosine arabinoside constant rate infusion without subsequent subcutaneous injections for the treatment of dogs with meningoencephalomyelitis of unknown origin.

Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid (2020)
Journal Article
Spankie, T. J., Haywood, A. L., Dottorini, T., Barrow, P. A., & Hirst, J. D. (2020). Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid. Journal of Molecular Graphics and Modelling, 101, Article 107723. https://doi.org/10.1016/j.jmgm.2020.107723

© 2020 Elsevier Inc. One promising strategy to combat antimicrobial resistance is to use bacteriophages that attach to the sex pili produced by transmissible antimicrobial resistance (AMR) plasmids, infect AMR bacteria and select for loss of the AMR... Read More about Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid.

Bacteriophage-induced lipopolysaccharide mutations in escherichia coli lead to hypersensitivity to food grade surfactant sodium dodecyl sulfate (2020)
Journal Article
Zhong, Z., Emond-Rheault, J. G., Bhandare, S., Lévesque, R., & Goodridge, L. (2020). Bacteriophage-induced lipopolysaccharide mutations in escherichia coli lead to hypersensitivity to food grade surfactant sodium dodecyl sulfate. Antibiotics, 9(9), Article 552. https://doi.org/10.3390/antibiotics9090552

Bacteriophages (phages) are considered as one of the most promising antibiotic alternatives in combatting bacterial infectious diseases. However, one concern of employing phage application is the emergence of bacteriophage-insensitive mutants (BIMs).... Read More about Bacteriophage-induced lipopolysaccharide mutations in escherichia coli lead to hypersensitivity to food grade surfactant sodium dodecyl sulfate.

Antimicrobial use practices and opinions of beef farmers in England and Wales (2020)
Journal Article
Doidge, C., Hudson, C. D., Burgess, R., Lovatt, F., & Kaler, J. (2020). Antimicrobial use practices and opinions of beef farmers in England and Wales. Veterinary Record, 187(12), e119-e119. https://doi.org/10.1136/vr.105878

© British Veterinary Association. Background Limited research exists on antimicrobial use practices of beef farmers. This study aimed to investigate antimicrobial practices and perceptions of beef farmers in England and Wales, and identify drivers of... Read More about Antimicrobial use practices and opinions of beef farmers in England and Wales.

Impact of neospora caninum infection on the bioenergetics and transcriptome of cerebrovascular endothelial cells (2020)
Journal Article
Elsheikha, H. M., Alkurashi, M., Palfreman, S., Castellanos, M., Kong, K., Ning, E., …MacNaughtan, W. (2020). Impact of neospora caninum infection on the bioenergetics and transcriptome of cerebrovascular endothelial cells. Pathogens, 9(9), Article 710. https://doi.org/10.3390/pathogens9090710

In this work, the effects of the protozoan Neospora caninum on the bioenergetics, chemical composition, and elemental content of human brain microvascular endothelial cells (hBMECs) were investigated. We showed that N. caninum can impair cell mitocho... Read More about Impact of neospora caninum infection on the bioenergetics and transcriptome of cerebrovascular endothelial cells.

ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis (2020)
Journal Article
Ebanks, B., Ingram, T. L., & Chakrabarti, L. (2020). ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis. Aging, 12(6), 16647—16662. https://doi.org/10.18632/aging.103867

It is estimated that over 44 million people across the globe have dementia, and half of these cases are believed to be Alzheimer's disease (AD). As the proportion of the global population which is over the age 60 increases so will the number of indiv... Read More about ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis.

Cryo-FIB-lift-out: practically impossible to practical reality (2020)
Journal Article
Parmenter, C. D., & Nizamudeen, Z. A. (2020). Cryo-FIB-lift-out: practically impossible to practical reality. Journal of Microscopy, https://doi.org/10.1111/jmi.12953

© 2020 The Authors. Journal of Microscopy published by John Wiley & Sons Ltd on behalf of Royal Microscopical Society In this paper, we explore the development of the Cryo-Lift-Out (cryo-LO) technique as preparation tool for cryogenic transmission... Read More about Cryo-FIB-lift-out: practically impossible to practical reality.

Incubation period of COVID-19: a rapid systematic review and meta-analysis of observational research (2020)
Journal Article
McAloon, C., Collins, Á., Hunt, K., Barber, A., Byrne, A. W., Butler, F., …More, S. J. (2020). Incubation period of COVID-19: a rapid systematic review and meta-analysis of observational research. BMJ Open, 10(8), Article e039652. https://doi.org/10.1136/bmjopen-2020-039652

Objectives: The aim of this study was to conduct a rapid systematic review and meta-analysis of estimates of the incubation period of COVID-19. Design: Rapid systematic review and meta-analysis of observational research. Setting: International... Read More about Incubation period of COVID-19: a rapid systematic review and meta-analysis of observational research.

Antibacterial and anti-virulence activity of manuka honey against genetically diverse Staphylococcus pseudintermedius (2020)
Journal Article
Brown, H. L., Metters, G., Hitchings, M. D., Wilkinson, T. S., Sousa, L., Cooper, J., …Jenkins, R. (2020). Antibacterial and anti-virulence activity of manuka honey against genetically diverse Staphylococcus pseudintermedius. Applied and Environmental Microbiology, 86(20), Article e01768-20. https://doi.org/10.1128/aem.01768-20

Staphylococcus pseudintermedius causes opportunistic infections in dogs. It also has significant zoonotic potential, with the emergence of multidrug-resistance leading to difficulty treating both animal and human infections. Manuka honey has previous... Read More about Antibacterial and anti-virulence activity of manuka honey against genetically diverse Staphylococcus pseudintermedius.

Farmers' Perceptions of Preventing Antibiotic Resistance on Sheep and Beef Farms: Risk, Responsibility, and Action (2020)
Journal Article
Doidge, C., Ruston, A., Lovatt, F., Hudson, C., King, L., & Kaler, J. (2020). Farmers' Perceptions of Preventing Antibiotic Resistance on Sheep and Beef Farms: Risk, Responsibility, and Action. Frontiers in Veterinary Science, 7, Article 524. https://doi.org/10.3389/fvets.2020.00524

© 2020 Doidge, Ruston, Lovatt, Hudson, King and Kaler. Antibiotic resistance is one of the most serious public health risks facing humanity. The overuse of antibiotics in the treatment of infectious disease have been identified as sources of the... Read More about Farmers' Perceptions of Preventing Antibiotic Resistance on Sheep and Beef Farms: Risk, Responsibility, and Action.

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza (2020)
Journal Article
Scott, C., Kankanala, J., Foster, T. L., Goldhill, D. H., Bao, P., Simmons, K., …Griffin, S. (2020). Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. PLoS Pathogens, 16(8), Article e1008716. https://doi.org/10.1371/journal.ppat.1008716

Pandemic influenza A virus (IAV) remains a significant threat to global health. Preparedness relies primarily upon a single class of neuraminidase (NA) targeted antivirals, against which resistance is steadily growing. The M2 proton channel is an alt... Read More about Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.

Serosurvey of pandemic H1N1 influenza A virus in dogs in Andalusia (southern Spain) (2020)
Journal Article
Jurado-Tarifa, E., Cano-Terriza, D., Daly, J. M., Arenas, A., & García-Bocanegra, I. (2020). Serosurvey of pandemic H1N1 influenza A virus in dogs in Andalusia (southern Spain). Zoonoses and Public Health, 67(8), 869-875. https://doi.org/10.1111/zph.12758

In April 2009, a new influenza A virus (IAV) subtype (A(H1N1)pdm09) spread worldwide and triggered the first human influenza pandemic of the 21st century. Since then, exposure to the pandemic H1N1 IAV has been confirmed in different animal species. S... Read More about Serosurvey of pandemic H1N1 influenza A virus in dogs in Andalusia (southern Spain).

Evaluating the role of surgical sterilisation in canine rabies control: A systematic review of impact and outcomes (2020)
Journal Article
Collinson, A., Bennett, M., Brennan, M. L., Dean, R., & Stavisky, J. (2020). Evaluating the role of surgical sterilisation in canine rabies control: A systematic review of impact and outcomes. PLoS Neglected Tropical Diseases, 14(8), https://doi.org/10.1371/journal.pntd.0008497

© 2020 Collinson et al. Current recommendations for the elimination of canine-mediated human rabies focus on mass dog vaccination as the most feasible and cost-effective strategy. However, attempts to control rabies are often combined with canine sur... Read More about Evaluating the role of surgical sterilisation in canine rabies control: A systematic review of impact and outcomes.