All Outputs (4)

Mechanistic basis of substrate–O2 coupling within a chitin-active lytic polysaccharide monooxygenase: An integrated NMR/EPR study (2020)
Journal Article
Courtade, G., Ciano, L., Paradisi, A., Lindley, P. J., Forsberg, Z., Sørlie, M., …Aachmann, F. L. (2020). Mechanistic basis of substrate–O2 coupling within a chitin-active lytic polysaccharide monooxygenase: An integrated NMR/EPR study. Proceedings of the National Academy of Sciences, 117(32), Article 202004277. https://doi.org/10.1073/pnas.2004277117

Lytic polysaccharide monooxygenases (LPMOs) have a unique ability to activate molecular oxygen for subsequent oxidative cleavage of glycosidic bonds. To provide insight into the mode of action of these industrially important enzymes, we have performe... Read More about Mechanistic basis of substrate–O2 coupling within a chitin-active lytic polysaccharide monooxygenase: An integrated NMR/EPR study.

Insights from semi-oriented EPR spectroscopy studies into the interaction of lytic polysaccharide monooxygenases with cellulose (2020)
Journal Article
Ciano, L., Paradisi, A., Hemsworth, G. R., Tovborg, M., Davies, G. J., & Walton, P. H. (2020). Insights from semi-oriented EPR spectroscopy studies into the interaction of lytic polysaccharide monooxygenases with cellulose. Dalton Transactions, 49(11), 3413-3422. https://doi.org/10.1039/c9dt04065j

Probing the detailed interaction between lytic polysaccharide monooxygenases (LPMOs) and their polysaccharide substrates is key to revealing further insights into the mechanism of action of this class of enzymes on recalcitrant biomass. This investig... Read More about Insights from semi-oriented EPR spectroscopy studies into the interaction of lytic polysaccharide monooxygenases with cellulose.

Discovery of a fungal copper radical oxidase with high catalytic efficiency towards 5-hydroxymethylfurfural and benzyl alcohols for bioprocessing (2020)
Journal Article
Mathieu, Y., Offen, W. A., Forget, S. M., Ciano, L., Viborg, A. H., Blagova, E., …Brumer, H. (2020). Discovery of a fungal copper radical oxidase with high catalytic efficiency towards 5-hydroxymethylfurfural and benzyl alcohols for bioprocessing. ACS Catalysis, 10(5), 3042-3058. https://doi.org/10.1021/acscatal.9b04727

Copyright © 2020 American Chemical Society. Alternatives to petroleum-based chemicals are highly sought-after for ongoing efforts to reduce the damaging effects of human activity on the environment. Copper radical oxidases from Auxiliary Activity Fam... Read More about Discovery of a fungal copper radical oxidase with high catalytic efficiency towards 5-hydroxymethylfurfural and benzyl alcohols for bioprocessing.

A fungal family of lytic polysaccharide monooxygenase-like copper proteins (2020)
Journal Article
Labourel, A., Frandsen, K. E. H., Zhang, F., Brouilly, N., Grisel, S., Haon, M., …Berrin, J. (2020). A fungal family of lytic polysaccharide monooxygenase-like copper proteins. Nature Chemical Biology, 16(3), 345–350. https://doi.org/10.1038/s41589-019-0438-8

Lytic polysaccharide monooxygenases (LPMOs) are copper-containing enzymes that play a key role in the oxidative degradation of various biopolymers such as cellulose and chitin. While hunting for new LPMOs, we identified in various fungal lineages... Read More about A fungal family of lytic polysaccharide monooxygenase-like copper proteins.