All Outputs (3)

Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model (2019)
Journal Article
Costa-Marques, L., Arnold, K., Pardon, M. C., Leovsky, C., Swarbrick, S., Fabian, C., & Stolzing, A. (2019). Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model. Translational Neurodegeneration, 8, Article 33. https://doi.org/10.1186/s40035-019-0173-9

© 2019 The Author(s). Background: We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice. Method: BM-M were transplanted into the tail ve... Read More about Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model.

Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease (2019)
Journal Article
Agostini, A., Yuchun, D., Li, B., Kendall, D. A., & Pardon, M. (2020). Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Brain, Behavior, and Immunity, 83, 87-111. https://doi.org/10.1016/j.bbi.2019.09.019

Systemic inflammation enhances the risk and progression of Alzheimer's disease (AD). Lipopolysaccharide (LPS), a potent pro-inflammatory endotoxin produced by the gut, is found in excess levels in AD where it associates with neurological hallmarks of... Read More about Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease.

Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge—Preliminary findings (2019)
Journal Article
Yanez Lopez, M., Pardon, M., Baiker, K., Prior, M., Yuchun, D., Agostini, A., …Faas, H. M. (2019). Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge—Preliminary findings. PLoS ONE, 14(2), Article e0212002. https://doi.org/10.1371/journal.pone.0212002

Neuroinflammation plays an important role in the pathogenesis of a range of brain disorders. Non-invasive imaging of neuroinflammation is critical to help improve our understanding of the underlying disease mechanisms, monitor therapies and guide dru... Read More about Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge—Preliminary findings.