All Outputs (2)

Protodepalladation as a Strategic Elementary Step in Catalysis (2018)
Journal Article
Engle, K., & O’Duill, M. (2018). Protodepalladation as a Strategic Elementary Step in Catalysis. SYNTHESIS, 50(24), 4699-4714. https://doi.org/10.1055/s-0037-1611064

Protodepalladation is the redox-neutral conversion of a C–Pd(II) bond into a C–H bond via reaction with a Brønsted acid. It is the microscopic reverse of Pd(II)-mediated C–H cleavage. In the context of catalytic reaction development, protodepalladati... Read More about Protodepalladation as a Strategic Elementary Step in Catalysis.

Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles (2018)
Journal Article
Derosa, J., O’Duill, M. L., Holcomb, M., Boulous, M. N., Patman, R. L., Wang, F., …Engle, K. M. (2018). Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles. Journal of Organic Chemistry, 83(7), 3417-3425. https://doi.org/10.1021/acs.joc.7b03100

Small molecules containing cyclopropane-heteroatom linkages are commonly needed in medicinal chemistry campaigns yet are problematic to prepare using existing methods. To address this issue, a scalable Chan-Lam cyclopropylation reaction using potassi... Read More about Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles.