All Outputs (4623)

Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells (2018)
Journal Article
Grundy, M., Balakrishnan, S., Fox, M., Seedhouse, C., & Russell, N. (2018). Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget, 9, Article 102. https://doi.org/10.18632/oncotarget.26540

Acute myeloid leukaemia (AML) cells often up-regulate pro-survival members of the BCL-2 protein family, such as BCL-2 and MCL-1, to avoid apoptosis. Venetoclax (ABT-199) targets BCL-2 and has shown promising efficacy in AML but over-expression of MCL... Read More about Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells.

The resilience paradox: flooding experience, coping and climate change mitigation intentions (2018)
Journal Article
Ogunbode, C. A., Böhm, G., Capstick, S. B., Demski, C., Spence, A., & Tausch, N. (2018). The resilience paradox: flooding experience, coping and climate change mitigation intentions. Climate Policy, 19(6), 703-715. https://doi.org/10.1080/14693062.2018.1560242

Climate change is projected to increase the frequency, intensity and unpredictability of extreme weather events across the globe and these events are likely to have significant mental health implications. The mental health literature broadly characte... Read More about The resilience paradox: flooding experience, coping and climate change mitigation intentions.

On the real catalytically active species for CO2 fixation into cyclic carbonates under near ambient conditions: dissociation equilibrium of [BMIm][Fe(NO)2Cl2] dependant on reaction temperature (2018)
Journal Article
Leu, M. K., Vicente, I., Fernandes, J. A., de Pedro, I., Dupont, J., Sans, V., …Cano, I. (2019). On the real catalytically active species for CO2 fixation into cyclic carbonates under near ambient conditions: dissociation equilibrium of [BMIm][Fe(NO)2Cl2] dependant on reaction temperature. Applied Catalysis B: Environmental, 245, 240-250. https://doi.org/10.1016/j.apcatb.2018.12.062

An imidazolium based iron-containing ionic liquid [BMIm][Fe(NO)2Cl2] (BMIm = 1-n-butyl-3-methyl-imidazolium) has been synthesized for the first time and fully characterized employing a wide range of techniques. The iron-based containing ionic liquid... Read More about On the real catalytically active species for CO2 fixation into cyclic carbonates under near ambient conditions: dissociation equilibrium of [BMIm][Fe(NO)2Cl2] dependant on reaction temperature.

Class 1 PI3K clinical candidates and recent inhibitor design strategies: a medicinal chemistry perspective (2018)
Journal Article
Garces, A. E., & Stocks, M. J. (2019). Class 1 PI3K clinical candidates and recent inhibitor design strategies: a medicinal chemistry perspective. Journal of Medicinal Chemistry, 62(10), 4815-4850. https://doi.org/10.1021/acs.jmedchem.8b01492

Phosphatidylinositol 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3-OH of the inositol ring of phosphoinositides, and deregulation of this pathway has implications in many diseases. The search for novel PI3K inhibitors has b... Read More about Class 1 PI3K clinical candidates and recent inhibitor design strategies: a medicinal chemistry perspective.

The professional development of counsellors and psychotherapists: Implications of empirical studies for supervision, training and practice (2018)
Journal Article
Rønnestad, M. H., Orlinsky, D. E., Schröder, T. A., Skovholt, T. M., & Willutzki, U. (2018). The professional development of counsellors and psychotherapists: Implications of empirical studies for supervision, training and practice. Counselling and Psychotherapy Research, 19(3), 214-230. https://doi.org/10.1002/capr.12198

Background: This article presents key findings of two major empirical studies of psychotherapist and counsellor development. Both aimed to advance knowledge of variations in professional development and better understand the complexity of formative i... Read More about The professional development of counsellors and psychotherapists: Implications of empirical studies for supervision, training and practice.

Demonstrably doing accountability in the internet of things (2018)
Journal Article
Urquhart, L., Lodge, T., & Crabtree, A. (2018). Demonstrably doing accountability in the internet of things. International Journal of Law and Information Technology, 27(1), 1-27. https://doi.org/10.1093/ijlit/eay015

This article explores the importance of accountability to data protection (DP), and how it can be built into the Internet of Things (IoT). The need to build accountability into the IoT is motivated by the opaque nature of distributed data flows, inad... Read More about Demonstrably doing accountability in the internet of things.

Functional categorisation of dietary fibre in foods: Beyond 'soluble’ vs ‘insoluble’ (2018)
Journal Article
Gidley, M. J., & Yakubov, G. E. (2019). Functional categorisation of dietary fibre in foods: Beyond 'soluble’ vs ‘insoluble’. Trends in Food Science and Technology, 86, 563-568. https://doi.org/10.1016/j.tifs.2018.12.006

© 2018 Elsevier Ltd Background: Diets rich in dietary fibre are associated with multiple health benefits, but there is often only a restricted understanding of the mechanisms underlying these associations. This limits the ability to select or design... Read More about Functional categorisation of dietary fibre in foods: Beyond 'soluble’ vs ‘insoluble’.

A systematic review of behaviour change techniques within interventions to prevent return to smoking postpartum (2018)
Journal Article
Brown, T. J., Hardeman, W., Bauld, L., Holland, R., Maskrey, V., Naughton, F., …Notley, C. (2019). A systematic review of behaviour change techniques within interventions to prevent return to smoking postpartum. Addictive Behaviors, 92, 236-243. https://doi.org/10.1016/j.addbeh.2018.12.031

Introduction: There is no routine support to prevent postpartum smoking relapse, due to lack of effective interventions. Previous reviews have identified behaviour change techniques (BCTs) within pregnancy cessation trials to specify which components... Read More about A systematic review of behaviour change techniques within interventions to prevent return to smoking postpartum.

Enhancing Robusta coffee aroma by modifying flavour precursors in the green coffee bean (2018)
Journal Article
Liu, C., Yang, N., Yang, Q., Ayed, C., Linforth, R., & Fisk, I. D. (2019). Enhancing Robusta coffee aroma by modifying flavour precursors in the green coffee bean. Food Chemistry, 281, 8-17. https://doi.org/10.1016/j.foodchem.2018.12.080

© 2018 Elsevier Ltd This study attempted to improve Robusta sensory properties by modifying the beans chemical composition. Building on our previous work, which modified bean pH through acid pre-treatment, a model system was developed where, sugar so... Read More about Enhancing Robusta coffee aroma by modifying flavour precursors in the green coffee bean.

Meso-scale modelling of 3D woven composite T-joints with weave variations (2018)
Journal Article
Yan, S., Zeng, X., & Long, A. (2019). Meso-scale modelling of 3D woven composite T-joints with weave variations. Composites Science and Technology, 171, 171-179. https://doi.org/10.1016/j.compscitech.2018.12.024

A meso-scale modelling framework is proposed to simulate the 3D woven fibre architectures and the mechanical performance of the composite T-joints, subjected to quasi-static tensile pull-off loading. The proposed method starts with building the reali... Read More about Meso-scale modelling of 3D woven composite T-joints with weave variations.

Frequency difference mapping applied to the corpus callosum at 7T (2018)
Journal Article
Tendler, B. C., & Bowtell, R. (2019). Frequency difference mapping applied to the corpus callosum at 7T. Magnetic Resonance in Medicine, 81(5), 3017-3031. https://doi.org/10.1002/mrm.27626

Purpose: Frequency difference mapping (FDM) is a phase processing technique which characterises the non-linear temporal evolution of the phase of gradient echo signals. Here, a novel FDM processing algorithm is introduced, which is shown to reveal in... Read More about Frequency difference mapping applied to the corpus callosum at 7T.

A novel approach for rational determination of warm mix asphalt production temperatures (2018)
Journal Article
Abed, A., Thom, N., & Grenfell, J. (2019). A novel approach for rational determination of warm mix asphalt production temperatures. Construction and Building Materials, 200, 80-93. https://doi.org/10.1016/j.conbuildmat.2018.12.082

Warm Mix Asphalt (WMA) has been developed to minimise environmental impact of asphalt by reducing production temperatures of this material. This study provides a new approach to design WMA production temperatures by two methods. First, aggregate coat... Read More about A novel approach for rational determination of warm mix asphalt production temperatures.

Prevalence and impact of self-reported irritable bowel symptoms in the general population (2018)
Journal Article
Van den Houte, K., Carbone, F., Pannemans, J., Corsetti, M., Fischler, B., Piessevaux, H., & Tack, J. (2019). Prevalence and impact of self-reported irritable bowel symptoms in the general population. United European Gastroenterology Journal, 7(2), 307-315. https://doi.org/10.1177/2050640618821804

Background and aims
The symptom-based diagnostic criteria for irritable bowel syndrome (IBS) have recently been revised in the Rome IV consensus. On the other hand, with rising public awareness of IBS, self-diagnosis and self-management is also incr... Read More about Prevalence and impact of self-reported irritable bowel symptoms in the general population.

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article
Rose, J., Sidney, L., Patient, J., White, L., Dua, H., El Haj, A., …Rose, F. (2018). In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft. Journal of Biomedical Materials Research Part A, 107(4), 828-838. https://doi.org/10.1002/jbm.a.36598

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More about In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft.

Evidence for Jahn-Teller effects in endohedral fullerenes (2018)
Journal Article
Dunn, J. L., & Rashed, E. (2018). Evidence for Jahn-Teller effects in endohedral fullerenes. Journal of Physics: Conference Series, 1148(1), https://doi.org/10.1088/1742-6596/1148/1/012003

Endohedral fullerenes can be formed by encapsulating one or more atom or molecule inside the cavity of the fullerene molecule. When a light molecule is encapsulated, it will remain close to the centre of the fullerene molecule without any strong inte... Read More about Evidence for Jahn-Teller effects in endohedral fullerenes.

The potential of the underutilized pulse bambara groundnut (Vigna subterranea (L.) Verdc.) for nutritional food security (2018)
Journal Article
Azman Halimi, R., Barkla, B. J., Mayes, S., & King, G. J. (2019). The potential of the underutilized pulse bambara groundnut (Vigna subterranea (L.) Verdc.) for nutritional food security. Journal of Food Composition and Analysis, 77, 47-59. https://doi.org/10.1016/j.jfca.2018.12.008

© 2019 Elsevier Inc. Bambara groundnut is an underutilized pulse that can make a positive contribution to food and nutritional security at the regional and global level, particularly in tropical developing countries where the crop is currently grown.... Read More about The potential of the underutilized pulse bambara groundnut (Vigna subterranea (L.) Verdc.) for nutritional food security.

The use of the QbTest in clinical practice (2018)
Journal Article
Hall, C. L., & Hollis, C. (2018). The use of the QbTest in clinical practice. ADHD in Practice, 10(3), 49-52

Diagnosing and managing attention deficit and hyperactivity disorder (ADHD) typically relies on subjective measures. When assessing children and young people for ADHD, the clinician gathers information from parents and teachers and uses these various... Read More about The use of the QbTest in clinical practice.

Locating primary somatosensory cortex in human brain stimulation studies: Experimental evidence (2018)
Journal Article
Holmes, N. P., Tamè, L., Beeching, P., Medford, M., Rakova, M., Stuart, A., & Zeni, S. (2018). Locating primary somatosensory cortex in human brain stimulation studies: Experimental evidence. Journal of Neurophysiology, 121(1), 336-344. https://doi.org/10.1152/jn.00641.2018

Transcranial magnetic stimulation (TMS) over human primary somatosensory cortex (S1) does not produce immediate outputs. Researchers must therefore rely on indirect methods for TMS coil positioning. The 'gold standard' is to use individual functional... Read More about Locating primary somatosensory cortex in human brain stimulation studies: Experimental evidence.

A robust Bayesian methodology for damage localization in plate-like structures using ultrasonic guided-waves (2018)
Journal Article
Cantero-Chinchilla, S., Chiachío, M., Chiachío, J., Chronopoulos, D., & Jones, A. (2019). A robust Bayesian methodology for damage localization in plate-like structures using ultrasonic guided-waves. Mechanical Systems and Signal Processing, 122, 192-205. https://doi.org/10.1016/j.ymssp.2018.12.021

SHM methods for damage detection and localization in plate-like structures have typically relied on signal post-processing techniques applied to ultrasonic guided-waves. The time of flight is one of these signals features which has been extensively u... Read More about A robust Bayesian methodology for damage localization in plate-like structures using ultrasonic guided-waves.

'This is not what we wanted': designing for conversation with voice interfaces (2018)
Journal Article
Reeves, S., Porcheron, M., & Fischer, J. (2019). 'This is not what we wanted': designing for conversation with voice interfaces. InterActions, 26(1), 46-51. https://doi.org/10.1145/3296699

Design is increasingly said to be about constructing conversations with end users [1]. Advances in underlying voice-related [2] technologies, coupled with the spread of voice-driven agents and dedicated devices such as the Amazon Echo, Google Home, a... Read More about 'This is not what we wanted': designing for conversation with voice interfaces.