All Outputs (4605)

Alien honeybees increase pollination risks for range-restricted plants (2018)
Journal Article

Aim:Range-restricted species are of high conservation concern and the way in which they interact with more widespread species has implications for their persistence. Here we determine how the specialisation of mutualistic interactions varies with res... Read More about Alien honeybees increase pollination risks for range-restricted plants.

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor (2018)
Journal Article

Deregulation of the cyclin-dependent kinases (CDKs) has been implicated in the pathogenesis of multiple cancer types. Consequently, CDKs have garnered intense interest as therapeutic targets for the treatment of cancer. We describe herein the molecul... Read More about Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.

In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa (2018)
Journal Article

Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis, wound and nosocomial infections, posing a serious burden to public health, due to its antibiotic resistance. The P. aeruginosa Pseudomonas Quinolone System (pqs) quorum sens... Read More about In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa.

Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis (2018)
Journal Article

AIM: To analyse the effect of mechanical bowel preparation vs no mechanical bowel preparation on outcome in patients undergoing elective colorectal surgery. METHODS: Meta-analysis of randomised controlled trials and observational studies comparing a... Read More about Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis.

Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia (2018)
Journal Article

© 2018 International Society for Neurochemistry. Sphingosine 1-phosphate receptors (S1PR) are G protein-coupled and compose a family with five subtypes, S1P1R–S1P5R. The drug Gilenya ® (Novartis, Basel, Switzerland) (Fingolimod; FTY720) targets S1PRs... Read More about Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia.

Allowance for boundary sharpening in the determination of diffusion coefficients by sedimentation velocity: a historical perspective. (2018)
Journal Article

This review summarizes endeavors undertaken in the middle of last century to employ the Lamm equation for quantitative analysis of boundary spreading in sedimentation velocity experiments on globular proteins, thereby illustrating the ingenuity requi... Read More about Allowance for boundary sharpening in the determination of diffusion coefficients by sedimentation velocity: a historical perspective..

Building accountability into the Internet of Things: the IoT Databox model (2018)
Journal Article

© 2018, The Author(s). This paper outlines the IoT Databox model as a means of making the Internet of Things (IoT) accountable to individuals. Accountability is a key to building consumer trust and is mandated by the European Union’s general data pro... Read More about Building accountability into the Internet of Things: the IoT Databox model.

Price adjustment in currency unions: another dimension to the endogeneity of the optimum currency area criteria? (2018)
Journal Article

In a rational expectations model, wages and prices should respond more to shocks in currency unions than under adjustable pegs because of the absence of exchange rate adjustment. This is an aspect of the endogeneity of the optimum currency area crite... Read More about Price adjustment in currency unions: another dimension to the endogeneity of the optimum currency area criteria?.

Investigation of a Surface PM Machine With Segmented-Eccentric Magnet Poles (2018)
Journal Article

This paper proposes a novel machine with segmented permanent magnets (PM) poles and optimized Halbach array having different eccentricities, i.e., the inner and outer arcs of the segmented PM have different centers. The electromagnetic property of th... Read More about Investigation of a Surface PM Machine With Segmented-Eccentric Magnet Poles.

Introduction (2018)
Book Chapter

The vast majority of businesses globally are small. If business is to be socially responsible, we need to go beyond the westernised concept of 'Corporate Social Responsibility', to develop 'Small Business Social Responsibility'. This agenda-setting R... Read More about Introduction.

Commutativity of the strain energy density expression for the benefit of the FEM implementation of Koiter's initial postbuckling theory (2018)
Journal Article

Copyright © 2018 John Wiley & Sons, Ltd. The concept of full commutativity of displacements in the expression for strain energy density for the geometrically nonlinear problem has been introduced for the first time and fully established in this pap... Read More about Commutativity of the strain energy density expression for the benefit of the FEM implementation of Koiter's initial postbuckling theory.

Vascular endothelial growth factor-A165b restores normal glomerular water permeability in a diphtheria-toxin mouse model of glomerular injury (2018)
Journal Article

BACKGROUND/AIMS:Genetic cell ablation using the human diphtheria toxin receptor (hDTR) is a new strategy used for analysing cellular function. Diphtheria toxin (DT) is a cytotoxic protein that leaves mouse cells relatively unaffected, but upon bindin... Read More about Vascular endothelial growth factor-A165b restores normal glomerular water permeability in a diphtheria-toxin mouse model of glomerular injury.

Detecting Lorentz violations with gravitational waves from black hole binaries (2018)
Journal Article

Gravitational wave observations have been used to test Lorentz symmetry by looking for dispersive effects that are caused by higher order corrections to the dispersion relation. In this Letter I argue on general grounds that, when such corrections ar... Read More about Detecting Lorentz violations with gravitational waves from black hole binaries.

Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke (2018)
Journal Article

Objective: To study the early time course of major bleeding and its subtypes in patients with cerebral ischemia on dual and single antiplatelet therapy. Methods: We performed a post hoc analysis on individual patient data from 6 randomized clinica... Read More about Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke.

Clumpy galaxies in CANDELS. II. Physical properties of UV-bright clumps at 0.5 ? z < 3 (2018)
Journal Article

Studying giant star-forming clumps in distant galaxies is important to understand galaxy formation and evolution. At present, however, observers and theorists have not reached a consensus on whether the observed "clumps" in distant galaxies are the s... Read More about Clumpy galaxies in CANDELS. II. Physical properties of UV-bright clumps at 0.5 ? z < 3.

Current status of feline lungworm in the UK (2018)
Journal Article

Phylogeographic diversity and mosaicism of the Helicobacter pylori tfs integrative and conjugative elements (2018)
Journal Article

Background: The genome of the gastric pathogen Helicobacter pylori is characterised by considerable variation of both gene sequence and content, much of which is contained within three large genomic islands comprising the cag pathogenicity island (ca... Read More about Phylogeographic diversity and mosaicism of the Helicobacter pylori tfs integrative and conjugative elements.

Understanding mortality in care facilities—the role of good data (2018)
Journal Article

Urn & Drum (2018)
Book

Vertical distribution and diurnal migration of atlantid heteropods (2018)
Journal Article

Understanding the vertical distribution and migratory behaviour of shelled holoplanktonic gastropods is essential in determining the environmental conditions to which they are exposed. This is increasingly important in understanding the effects of oc... Read More about Vertical distribution and diurnal migration of atlantid heteropods.