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Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A165a, VEGF-A165b, PIGF and VE-cadherin (2017)
Journal Article
Pang, V., Bates, D. O., & Leach, L. (2017). Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A165a, VEGF-A165b, PIGF and VE-cadherin. Clinical Science, 131(23), 2763-2775. https://doi.org/10.1042/CS20171252

The human placenta nourishes and protects the developing fetus whilst influencing maternal physiology for fetal advantage. It expresses several members of the VEGF family including the pro-angiogenic/pro-permeability VEGF-A165a isoform, the anti-angi... Read More about Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A165a, VEGF-A165b, PIGF and VE-cadherin.

NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy (2017)
Journal Article
Rossi, F., Geiszler, P. C., Meng, W., Barron, M., Prior, M., Herd-Smith, A., …Conforti, L. (2018). NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural Brain Research, 339, https://doi.org/10.1016/j.bbr.2017.11.030

NAD metabolism and the NAD biosynthetic enzymes nicotinamide nucleotide adenylyltransferases (NMNATs) are thought to play a key neuroprotective role in tauopathies, including Alzheimer’s disease. Here, we investigated whether modulating the expressio... Read More about NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy.

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development (2017)
Journal Article
Ghosh, T. K., Aparicio-Sánchez, J. J., Buxton, S., Ketley, A., Mohamed, T., Rutland, C. S., …Brook, J. D. (2018). Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development. Journal of Molecular and Cellular Cardiology, 114, 185-198. https://doi.org/10.1016/j.yjmcc.2017.11.013

© 2017 Elsevier Ltd TBX5 plays a critical role in heart and forelimb development. Mutations in TBX5 cause Holt-Oram syndrome, an autosomal dominant condition that affects the formation of the heart and upper-limb. Several studies have provided signif... Read More about Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.

Single-gene speciation: mating and gene flow between mirror-image snails (2017)
Journal Article
Richards, P. M., Morii, Y., Kimura, K., Hirano, T., Chiba, S., & Davison, A. (2017). Single-gene speciation: mating and gene flow between mirror-image snails. Evolution Letters, 1(6), https://doi.org/10.1002/evl3.31

Variation in the shell coiling, or chirality, of land snails provides an opportunity to investigate the potential for “single-gene” speciation, because mating between individuals of opposite chirality is believed not possible if the snails mate in a... Read More about Single-gene speciation: mating and gene flow between mirror-image snails.

Multi-timescale analysis of a metabolic network in synthetic biology: a kinetic model for 3-hydroxypropionic acid production via beta-alanine (2017)
Journal Article
Dalwadi, M. P., King, J. R., & Minton, N. P. (2018). Multi-timescale analysis of a metabolic network in synthetic biology: a kinetic model for 3-hydroxypropionic acid production via beta-alanine. Journal of Mathematical Biology, 77(1), 165-199. https://doi.org/10.1007/s00285-017-1189-3

A biosustainable production route for 3-hydroxypropionic acid (3HP), an important platform chemical, would allow 3HP to be produced without using fossil fuels. We are interested in investigating a potential biochemical route to 3HP from pyruvate thro... Read More about Multi-timescale analysis of a metabolic network in synthetic biology: a kinetic model for 3-hydroxypropionic acid production via beta-alanine.

Mathematical modelling of chemical agent removal by reaction with an immiscible cleanser (2017)
Journal Article
Dalwadi, M. P., O'Kiely, D., Thomson, S., Khaleque, T., & Hall, C. (in press). Mathematical modelling of chemical agent removal by reaction with an immiscible cleanser. SIAM Journal on Applied Mathematics, 77(6), https://doi.org/10.1137/16M1101647

When a hazardous chemical agent has soaked into a porous medium, such as concrete, it can be difficult to neutralise. One removal method is chemical decontamination, where a cleanser is applied to react with and neutralise the agent, forming less har... Read More about Mathematical modelling of chemical agent removal by reaction with an immiscible cleanser.

An integrated dyspepsia module for first year Pharmacy students: a flexible and generic template for integrating science with clinical and professional practice (2017)
Journal Article
De Matteis, C. I., Randall, M. D., Harvey, E. J., Morris, A., Winkler, G. S., & Boardman, H. F. (2019). An integrated dyspepsia module for first year Pharmacy students: a flexible and generic template for integrating science with clinical and professional practice. American Journal of Pharmaceutical Education, 83(1), Article 6508. https://doi.org/10.5688/ajpe6508

Objective: To design an integrated dyspepsia module for first year pharmacy undergraduates, which combines clinical and professional practice with fundamental sciences, in five different science subject areas, as a prototype for future disease- or sy... Read More about An integrated dyspepsia module for first year Pharmacy students: a flexible and generic template for integrating science with clinical and professional practice.

Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students (2017)
Journal Article
Oldfield, N. J., Green, L. R., Parkhill, J., Bayliss, C. D., & Turner, D. P. (2018). Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students. Journal of Infectious Diseases, 217(4), 608-616. https://doi.org/10.1093/infdis/jix596

Background In the UK rising disease levels due to Neisseria meningitidis serogroup W clonal complex ST-11 (MenW:cc11) strains led to introduction of conjugate MenACWY vaccination for teenagers. We investigated the impact of immunization on carriag... Read More about Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students.

High-throughput approaches for screening and analysis of cell behaviors (2017)
Journal Article
Seo, J., Shin, J. Y., Leijten, J., Jeon, O., Camci-Unal, G., Dikina, A. D., …Khademhosseini, A. (2018). High-throughput approaches for screening and analysis of cell behaviors. Biomaterials, 153, 85-101. https://doi.org/10.1016/j.biomaterials.2017.06.022

The rapid development of new biomaterials and techniques to modify them challenge our capability to characterize them using conventional methods. In response, numerous high-throughput (HT) strategies are being developed to analyze biomaterials and th... Read More about High-throughput approaches for screening and analysis of cell behaviors.

Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development (2017)
Journal Article
Saini, E., Zeeshan, M., Brady, D., Pandey, R., Kaiser, G., Koreny, L., …Tewari, R. (in press). Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development. Scientific Reports, 7(1), Article 15577. https://doi.org/10.1038/s41598-017-15781-z

Plasmodium parasites, the causative agents of malaria, possess a distinctive membranous structure of flattened alveolar vesicles supported by a proteinaceous network, and referred to as the inner membrane complex (IMC). The IMC has a role in actomyos... Read More about Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development.

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1 (2017)
Journal Article
Mesalam, A. A., Desombere, I., Farhoudi, A., Van Houtte, F., Verhoye, L., Ball, J., …Meuleman, P. (2018). Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1. Virology, 514, https://doi.org/10.1016/j.virol.2017.10.019

Monoclonal antibodies (mAbs) targeting the hepatitis C virus (HCV) envelope have been raised mainly against envelope protein 2 (E2), while the antigenic epitopes of envelope protein 1 (E1) are not fully identified. Here we describe the detailed chara... Read More about Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1.

Recombinant expression and characterisation of the oxygen-sensitive 2-enoate reductase from Clostridium sporogenes (2017)
Journal Article
Mordaka, P. M., Hall, S. J., Minton, N. P., & Stephens, G. (in press). Recombinant expression and characterisation of the oxygen-sensitive 2-enoate reductase from Clostridium sporogenes. Microbiology, https://doi.org/10.1099/mic.0.000568

‘Ene’-reductases have attracted significant attention for the preparation of chemical intermediates and biologically active products. To date, research has been focussed primarily on Old Yellow Enzyme-like proteins, due to their ease of handling, whe... Read More about Recombinant expression and characterisation of the oxygen-sensitive 2-enoate reductase from Clostridium sporogenes.

Genetic diversity and ecology of the planktonic foraminifers Globigerina bulloides, Turborotalita quinqueloba and Neogloboquadrina pachyderma off the Oman margin during the late SW Monsoon (2017)
Journal Article
Darling, K. F., Wade, C. M., Siccha, M., Trommer, G., Schulz, H., Abdolalipour, S., & Kurasawa, A. (2017). Genetic diversity and ecology of the planktonic foraminifers Globigerina bulloides, Turborotalita quinqueloba and Neogloboquadrina pachyderma off the Oman margin during the late SW Monsoon. Marine Micropaleontology, 137, 64-77. https://doi.org/10.1016/j.marmicro.2017.10.006

© 2017 The Authors The tropical waters of the Arabian Sea are among the richest biological areas of the world. The highly complex monsoonal system is particularly challenging for palaeoenvironmental study, which relies heavily upon understanding the... Read More about Genetic diversity and ecology of the planktonic foraminifers Globigerina bulloides, Turborotalita quinqueloba and Neogloboquadrina pachyderma off the Oman margin during the late SW Monsoon.

Vitamin intake is associated with improved visuospatial and verbal semantic memory in middle-aged individuals (2017)
Journal Article
Flitton, M., MacDonald, I. A., & Knight, H. M. (2019). Vitamin intake is associated with improved visuospatial and verbal semantic memory in middle-aged individuals. Nutritional Neuroscience, 22(6), 401-408. https://doi.org/10.1080/1028415X.2017.1395550

Objectives: Factors maintaining cognitive health are still largely unknown. In particular, the cognitive benefits associated with vitamin intake and vitamin supplementation are disputed. We investigated self-reported vitamin intake and serum vitami... Read More about Vitamin intake is associated with improved visuospatial and verbal semantic memory in middle-aged individuals.

Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis (2017)
Journal Article
Doherty, F. D., O’Mahony, S. M., Peterson, V. L., O’Sullivan, O., Crispie, F., Cotter, P. D., …Fone, K. C. (2018). Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis. Brain, Behavior, and Immunity, 68, 261-273. https://doi.org/10.1016/j.bbi.2017.10.024

Early-life stress is an established risk for the development of psychiatric disorders. Post-weaning isolation rearing of rats produces lasting developmental changes in behavior and brain function that may have translational pathophysiological relevan... Read More about Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis.

A monoclonal antibody raised against a thermo-stabilised ?1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of 1- adrenoceptors expressed in stable cell lines (2017)
Journal Article
Soave, M., Cseke, G., Hutchings, C. J., Brown, A. J., Woolard, J., & Hill, S. J. (2018). A monoclonal antibody raised against a thermo-stabilised ?1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of 1- adrenoceptors expressed in stable cell lines. Biochemical Pharmacology, 147, https://doi.org/10.1016/j.bcp.2017.10.015

Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turkey ?1-adrenoceptor (?1AR-... Read More about A monoclonal antibody raised against a thermo-stabilised ?1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of 1- adrenoceptors expressed in stable cell lines.

Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development (2017)
Journal Article
H-T. Kwok, C., Devonshire, I. M., Imraish, A., Greenspon, C. M., Lockwood, S., Fielden, C., …Hathway, G. J. (2017). Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. PAIN, 158(11), 2222-2232. https://doi.org/10.1097/j.pain.0000000000001027

Significant age and experience-dependent remodelling of spinal and supraspinal neural networks occur resulting in altered pain responses in early life. In adults endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which mod... Read More about Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development.

Increased efficiency in the second-hand tire trade provides opportunity for dengue control (2017)
Journal Article
Pliego Pliego, E., Velázquez-Castro, J., Eichhorn, M. P., & Fraguela Collar, A. (2018). Increased efficiency in the second-hand tire trade provides opportunity for dengue control. Journal of Theoretical Biology, 437, https://doi.org/10.1016/j.jtbi.2017.10.025

Dengue fever is increasing in geographical range, spread by invasion of its vector mosquitoes. The trade in second-hand tires has been implicated as a factor in this process because they act as mobile reservoirs of mosquito eggs and larvae. Regional... Read More about Increased efficiency in the second-hand tire trade provides opportunity for dengue control.

Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism (2017)
Journal Article
Nemajerova, A., Amelio, I., Gebel, J., Dötsch, V., Melino, G., & Moll, U. M. (2018). Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism. Cell Death and Differentiation, 25(1), 144-153. https://doi.org/10.1038/cdd.2017.178

The p53 family of transcription factors (p53, p63 and p73) covers a wide range of functions critical for development, homeostasis and health of mammals across their lifespan. Beside the well-established tumor suppressor role, recent evidence has high... Read More about Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism.