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All Outputs (9)

Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis (2015)
Journal Article
Doleman, B., Read, D., Lund, J. N., & Williams, J. P. (2015). Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis. Regional Anesthesia and Pain Medicine, 40(6), https://doi.org/10.1097/AAP.0000000000000311

Background and Objectives: Preventive analgesia has been proposed as a potential strategy to reduce postoperative pain. However, there is currently no review that focuses on acetaminophen for preventive analgesia. Methods: We conducted a search of... Read More about Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis.

The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply (2015)
Journal Article
Mitchell, W. K., Phillips, B. E., Williams, J. P., Rankin, D., Lund, J. N., Wilkinson, D. J., …Atherton, P. J. (2015). The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply. AJP - Endocrinology and Metabolism, 309(5), Article E450-E457. https://doi.org/10.1152/ajpendo.00112.2015

Essential amino acids (EAA) are responsible for skeletal muscle anabolic effects after nutrient intake. The pattern of appearance of EAA in blood, e.g., after intake of “slow” or “fast” protein sources or in response to grazing vs. bolus feeding patt... Read More about The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply.

A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain (2015)
Journal Article
Doleman, B., Heinink, T., Faleiro, R., Lund, J. N., & Williams, J. P. (2015). A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. Anaesthesia, 70(10), https://doi.org/10.1111/anae.13179

We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until December 2014 and included 133 randomised controlled trials of peri-operative gabapentin vs placebo. Gabapentin reduced mean (95% CI) 24-h morphine-equivalent consumption by 8.44 (... Read More about A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain.

Day-case closure of ileostomy: feasible, safe and efficient (2015)
Journal Article
Bhalla, A., Peacock, O., Tierney, G., Tou, S., Hurst, N., Speake, W., …Lund, J. N. (2015). Day-case closure of ileostomy: feasible, safe and efficient. Colorectal Disease, 17(9), https://doi.org/10.1111/codi.12961

Aim Over 5000 loop ileostomy closures were performed in the UK in 2013 with a median inpatient stay of 5 days. Previously we have successfully implemented a 23-h protocol for loop ileostomy closure which was modified for same-day discharge. We pre... Read More about Day-case closure of ileostomy: feasible, safe and efficient.

Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression (2015)
Journal Article
Gakhar, H., Dhillon, A., Blackwell, J., Hussain, K., Bommireddy, R., Klezl, Z., & Williams, J. (2015). Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression. European Spine Journal, 24(10), 2150-2155. https://doi.org/10.1007/s00586-015-4050-7

Background Age-related loss of functional muscle mass is associated with reduced functional ability and life expectancy. In disseminated cancer, age-related muscle loss may be exacerbated by cachexia and poor nutritional intake, increasing functio... Read More about Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression.

The effects of resistance exercise training on macro- and micro-circulatory responses to feeding and skeletal muscle protein anabolism in older men (2015)
Journal Article
Phillips, B. E., Atherton, P. J., Varadhan, K., Limb, M. C., Wilkinson, D. J., Sjøberg, K. A., …Williams, J. P. (2015). The effects of resistance exercise training on macro- and micro-circulatory responses to feeding and skeletal muscle protein anabolism in older men. Journal of Physiology, 593(12), https://doi.org/10.1113/JP270343

The anabolic effects of dietary protein on skeletal muscle depend on adequate skeletal muscle perfusion, which is impaired in older people. This study explores fed state muscle microvascular blood flow, protein metabolism and exercise training status... Read More about The effects of resistance exercise training on macro- and micro-circulatory responses to feeding and skeletal muscle protein anabolism in older men.

Creatinine and myoglobin are poor predictors of anaerobic threshold in colorectal cancer and health (2015)
Journal Article
Nyasavajjala, S. M., Phillips, B. E., Lund, J. N., & Williams, J. P. (2015). Creatinine and myoglobin are poor predictors of anaerobic threshold in colorectal cancer and health. Journal of Cachexia, Sarcopenia and Muscle, 6(2), https://doi.org/10.1002/jcsm.12020

Aims Myoglobin is a haem protein produced in skeletal muscles. Serum concentrations of myoglobin have been proposed as a surrogate marker of muscle mass and function in both cachectic cancer patients and healthy non-cancer individuals. Creatinine,... Read More about Creatinine and myoglobin are poor predictors of anaerobic threshold in colorectal cancer and health.

Assessing surgeon stress when operating using heart rate variability and the State Trait Anxiety Inventory: will surgery be the death of us? (2015)
Journal Article
Jones, K., Amawi, F., Bhalla, A., Peacock, O., Williams, J. P., & Lund, J. N. (2015). Assessing surgeon stress when operating using heart rate variability and the State Trait Anxiety Inventory: will surgery be the death of us?. Colorectal Disease, 17(4), https://doi.org/10.1111/codi.12844

Aim Performance in the operating room is affected by a combination of individual, patient and environmental factors amongst others. Stress has a potential negative impact on performance with the quality of surgical practice and patient safety bein... Read More about Assessing surgeon stress when operating using heart rate variability and the State Trait Anxiety Inventory: will surgery be the death of us?.