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Human leukocyte antigen genetic risk factors of drug-induced liver toxicology (2014)
Journal Article
Grove, J., & Aithal, G. (2014). Human leukocyte antigen genetic risk factors of drug-induced liver toxicology. Expert Opinion on Drug Metabolism and Toxicology, 11(3), 395-409. https://doi.org/10.1517/17425255.2015.992414

Introduction: Drug-induced liver injury (DILI) is a rare adverse drug reaction, which impacts significantly on patients. Human leukocyte antigen (HLA) risk alleles have been found to be associated with DILI supporting an immunological basis to DILI p... Read More about Human leukocyte antigen genetic risk factors of drug-induced liver toxicology.

Development of microspheres for biomedical applications: a review (2014)
Journal Article
Hossain, K. M. Z., Patel, U., & Ahmed, I. (2015). Development of microspheres for biomedical applications: a review. Progress in Biomaterials, 4(1), https://doi.org/10.1007/s40204-014-0033-8

An overview of microspheres manufactured for use in biomedical applications based on recent literature is presented in this review. Different types of glasses (i.e. silicate, borate, and phosphates), ceramics and polymer-based microspheres (both natu... Read More about Development of microspheres for biomedical applications: a review.

Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment (2014)
Journal Article
Füchtemeier, M., Brinckmann, M. P., Foddis, M., Kunz, A., Po, C., Curato, C., Dirnagl, U., & Farr, T. D. (2015). Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment. Journal of Cerebral Blood Flow and Metabolism, 35(3), https://doi.org/10.1038/jcbfm.2014.221

Our aims were to assess the spatiotemporal development of brain pathology in a mouse model of chronic hypoperfusion using magnetic resonance imaging (MRI), and to test whether the renin-angiotensin system (RAS) can offer therapeutic benefit. For the... Read More about Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment.

Cannabinoids in experimental stroke: a systematic review and meta-analysis (2014)
Journal Article
England, T. J., Hind, W. H., Rasid, N. A., & O'Sullivan, S. (2015). Cannabinoids in experimental stroke: a systematic review and meta-analysis. Journal of Cerebral Blood Flow and Metabolism, 35(3), https://doi.org/10.1038/jcbfm.2014.218

Cannabinoids (CBs) show promise as neuroprotectants with some agents already licensed in humans for other conditions. We systematically reviewed CBs in preclinical stroke to guide further experimental protocols. We selected controlled studies assessi... Read More about Cannabinoids in experimental stroke: a systematic review and meta-analysis.

A four-legs matrix converter ground power unit with repetitive voltage control (2014)
Journal Article
Rohuma, W., Zanchetta, P., Wheeler, P., & Empringham, L. (2015). A four-legs matrix converter ground power unit with repetitive voltage control. IEEE Transactions on Industrial Electronics, 62(4), https://doi.org/10.1109/TIE.2014.2379585

In this paper, a four-leg matrix converter is proposed as the power conversion core for aircraft ground power unit (GPU) applications. This structure allows easy management of unbalanced and nonlinear loads with minimal disruption of the power supply... Read More about A four-legs matrix converter ground power unit with repetitive voltage control.

Laplace approximation of Lauricella functions F A and F D (2014)
Journal Article
Butler, R., & Wood, A. T. (2015). Laplace approximation of Lauricella functions F A and F D. Advances in Computational Mathematics, 41(6), https://doi.org/10.1007/s10444-014-9397-5

The Lauricella functions, which are generalizations of the Gauss hypergeometric function 2 F 1, arise naturally in many areas of mathematics and statistics. So far as we are aware, there is little or nothing in the literature on how to calculate nume... Read More about Laplace approximation of Lauricella functions F A and F D.

Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers (2014)
Journal Article
Ebrahim, N. A., & Leach, L. (2015). Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers. Stem Cells and Development, 24(4), https://doi.org/10.1089/scd.2014.0207

Mesenchymal stem cells from Wharton’s jelly of human umbilical cords (WJ-MSC) are a valuable alternate source of stem cells. Their role in situ and whether they can interact and cross intact endothelial monolayers requires elucidation. The aim of thi... Read More about Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers.

A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men (2014)
Journal Article
Mitchell, W. K., Phillips, B. E., Williams, J. P., Rankin, D., Lund, J. N., Smith, K., & Atherton, P. J. (2015). A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men. Journal of Nutrition, 145(2), https://doi.org/10.3945/jn.114.199604

Background: The anabolic response of skeletal muscle to essential amino acids (EAAs) is dose dependent, maximal at modest doses, and short lived, even with continued EAA availability, a phenomenon termed “muscle-full.” However, the effect of EAA inge... Read More about A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men.

Overview of the SDSS-IV MaNGA survey: mapping nearby galaxies at Apache Point Observatory (2014)
Journal Article
Bundy, K., Bershady, M. A., Law, D. R., Yan, R., Drory, N., MacDonald, N., Wake, D. A., Cherinka, B., Sánchez-Gallego, J. R., Weijmans, A.-M., Thomas, D., Tremonti, C., Masters, K., Coccato, L., Diamond-Stanic, A. M., Aragón-Salamanca, A., Avila-Reese, V., Badenes, C., Falcón-Barroso, J., Belfiore, F., …Zhang, K. (2014). Overview of the SDSS-IV MaNGA survey: mapping nearby galaxies at Apache Point Observatory. Astrophysical Journal, 798(1), 7. https://doi.org/10.1088/0004-637x/798/1/7

We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1.... Read More about Overview of the SDSS-IV MaNGA survey: mapping nearby galaxies at Apache Point Observatory.

Implementing an Injury Prevention Briefing to aid delivery of key fire safety messages in UK children’s centres: qualitative study nested within a multi-centre randomised controlled trial (2014)
Journal Article
Beckett, K., Goodenough, T., Deave, T., Jaeckle, S., McDaid, L., Benford, P., Hayes, M., Towner, E., & Kendrick, D. (2014). Implementing an Injury Prevention Briefing to aid delivery of key fire safety messages in UK children’s centres: qualitative study nested within a multi-centre randomised controlled trial. BMC Public Health, 14(1256), https://doi.org/10.1186/1471-2458-14-1256

Background

To improve the translation of public health evidence into practice, there is a need to increase practitioner involvement in initiative development, to place greater emphasis on contextual knowledge, and to address intervention processes... Read More about Implementing an Injury Prevention Briefing to aid delivery of key fire safety messages in UK children’s centres: qualitative study nested within a multi-centre randomised controlled trial.

Cigarette smoke and the induction of urokinase plasminogen activator receptor in vivo: selective contribution of isoforms to bronchial epithelial phenotype (2014)
Journal Article
Portelli, M. A., Stewart, C. E., Hall, I. P., Brightling, C. E., & Sayers, I. (2015). Cigarette smoke and the induction of urokinase plasminogen activator receptor in vivo: selective contribution of isoforms to bronchial epithelial phenotype. American Journal of Respiratory Cell and Molecular Biology, 53(2), 174-183. https://doi.org/10.1165/rcmb.2014-0296oc

The urokinase plasminogen activator receptor (uPAR) gene (PLAUR) has been identified as an asthma susceptibility gene, with polymorphisms within that gene being associated with baseline lung function, lung function decline, and lung function in a smo... Read More about Cigarette smoke and the induction of urokinase plasminogen activator receptor in vivo: selective contribution of isoforms to bronchial epithelial phenotype.

Modeling tools for dengue risk mapping - a systematic review (2014)
Journal Article
Louis, V., Phalkey, R., Horstick, O., Ratanawong, P., Wilder-Smith, A., Tozan, Y., & Dambach, P. (2014). Modeling tools for dengue risk mapping - a systematic review. International Journal of Health Geographics, 13, 1-15. https://doi.org/10.1186/1476-072X-13-50

Introduction
The global spread and the increased frequency and magnitude of epidemic dengue in the last 50 years underscore the urgent need for effective tools for surveillance, prevention, and control. This review aims at providing a systematic ove... Read More about Modeling tools for dengue risk mapping - a systematic review.

The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans (2014)
Journal Article
Etheridge, T., Rahman, M., Gaffney, C. J., Shaw, D., Shephard, F., Magudia, J., Solomon, D. E., Milne, T., Blawzdziewicz, J., Constantin-Teodosiu, D., Greenhaff, P. L., Vanapalli, S. A., & Szewcyzk, N. (2015). The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans. FASEB Journal, 29(4), 1235-1246. https://doi.org/10.1096/fj.14-259119

The integrin-adhesome network, which contains >150 proteins, is mechano-transducing and located at discreet positions along the cell-cell and cell-extracellular matrix interface. A small subset of the integrin-adhesome is known to maintain normal mus... Read More about The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans.

Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity (2014)
Journal Article
Sanni, O., Chang, C.-Y., Anderson, D. G., Langer, R., Davies, M. C., Williams, P. M., Williams, P., Alexander, M. R., & Hook, A. L. (2015). Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity. Advanced Healthcare Materials, 4(5), 695-701. https://doi.org/10.1002/adhm.201400648

A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria i... Read More about Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity.

Investigating the micro mechanics of cemented sand using DEM (2014)
Journal Article
de Bono, J. P., McDowell, G. R., & Wanatowski, D. (2015). Investigating the micro mechanics of cemented sand using DEM. International Journal for Numerical and Analytical Methods in Geomechanics, 39(6), https://doi.org/10.1002/nag.2340

The discrete element method has been used to investigate the micro mechanics of cemented sand. High pressure drained triaxial tests are modelled in 3D using a flexible membrane which allows the correct deformation to develop. Simulations with up to... Read More about Investigating the micro mechanics of cemented sand using DEM.

Personal inquiry: orchestrating science investigations within and beyond the classroom (2014)
Journal Article
Sharples, M., Scanlon, E., Ainsworth, S. E., Anastopoulou, S., Collins, T., Crook, C., Jones, A., Kerawalla, L., Littleton, K., Mulholland, P., & O’Malley, C. (2015). Personal inquiry: orchestrating science investigations within and beyond the classroom. Journal of the Learning Sciences, 24(2), 308-341. https://doi.org/10.1080/10508406.2014.944642

A central challenge for science educators is to enable young people to act as scientists by gathering and assessing evidence, conducting experiments, and engaging in informed debate. We report the design of the nQuire toolkit, a system to support scr... Read More about Personal inquiry: orchestrating science investigations within and beyond the classroom.