Caspase-1 is a novel target of p63 in tumor suppression

Celardo, I; Grespi, F; Antonov, A; Bernassola, F; Garabadgiu, A V; Melino, G; Amelio, I

doi:10.1038/cddis.2013.175

All Outputs (4)

miR-24 affects hair follicle morphogenesis targeting Tcf-3 (2013)
Journal Article
Amelio, I., Lena, A. M., Bonanno, E., Melino, G., & Candi, E. (2013). miR-24 affects hair follicle morphogenesis targeting Tcf-3. Cell Death and Disease, 4(11), https://doi.org/10.1038/cddis.2013.426

During embryonic development, hair follicles (HFs) develop from an epidermal–mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis a... Read More about miR-24 affects hair follicle morphogenesis targeting Tcf-3.

p73 regulates serine biosynthesis in cancer (2013)
Journal Article
Amelio, I., Markert, E. K., Rufini, A., Antonov, A. V., Sayan, B. S., Tucci, P., …Melino, G. (2014). p73 regulates serine biosynthesis in cancer. Oncogene, 33(42), 5039-5046. https://doi.org/10.1038/onc.2013.456

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation (2013)
Journal Article
Velletri, T., Romeo, F., Tucci, P., Peschiaroli, A., Annicchiarico-Petruzzelli, M., Niklison-Chirou, M., …Agostini, M. (2013). GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation. Cell Cycle, 12(22), 3564-3573. https://doi.org/10.4161/cc.26771

The amino acid Glutamine is converted into Glutamate by a deamidation reaction catalyzed by the enzyme Glutaminase (GLS). Two isoforms of this enzyme have been described, and the GLS2 isoform is regulated by the tumor suppressor gene p53. Here, we sh... Read More about GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation.

Caspase-1 is a novel target of p63 in tumor suppression (2013)
Journal Article
Celardo, I., Grespi, F., Antonov, A., Bernassola, F., Garabadgiu, A. V., Melino, G., & Amelio, I. (2013). Caspase-1 is a novel target of p63 in tumor suppression. Cell Death and Disease, 4(5), https://doi.org/10.1038/cddis.2013.175

p63 is a p53 family transcription factor, which besides unique roles in epithelial development, shares tumor suppressive activity with its homolog p53. The p63 gene has different transcriptional start sites, which generate two N-terminal isoforms (tr... Read More about Caspase-1 is a novel target of p63 in tumor suppression.