All Outputs (663)

The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments (2012)
Journal Article

The pentacyclic acridinium salt RHPS4 displays anti-tumour properties in vitro as well as in vivo and is potentially cell-cycle specific. We have collected experimental data and formulated a compartmental model using ordinary differential equations t... Read More about The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments.

Dorsal hippocampal involvement in appetitive trace conditioning and interval timing (2012)
Journal Article

Involvement of the dorsal hippocampus (DHPC) in acquisition of Pavlovian trace conditioning and interval timing was examined in an appetitive preparation in which presentations of one conditioned stimulus (CS) were immediately followed by food (delay... Read More about Dorsal hippocampal involvement in appetitive trace conditioning and interval timing.

Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing (2012)
Journal Article

The involvement of the rat dorsal hippocampus (dhpc) in Pavlovian conditioning and timing of conditioned responding was examined in an appetitive preparation in which presentation of a relatively long, 40-s auditory conditioned stimulus (CS) was foll... Read More about Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing.

Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite (2012)
Journal Article

Dendritic cells (DCs) have been shown to play a key role in the initiation and maintenance of immune responses to microbial pathogens as well as to allergens, but the exact mechanisms of their involvement in allergic responses and Th2 cell differenti... Read More about Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite.

Variable Expression of Human beta Defensins 3 and 9 at the Human Ocular Surface in Infectious Keratitis (2012)
Journal Article

A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor (2012)
Journal Article

The recent publication of both the antagonist- and agonist-bound structures of the adenosine A(2A) receptor have revealed much about how a ligand may bind to a receptor and cause the conformational changes associated with agonist-mediated activation.... Read More about A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor.

Grey sets and greyness (2012)
Journal Article

This paper discusses the application of grey numbers for uncertainty representation. It highlights the difference between grey sets and interval-valued fuzzy sets, and investigates the degree of greyness for grey sets. It facilitates the representati... Read More about Grey sets and greyness.

Similar behaviour, different brain patterns: age-related changes in neural signatures of ignoring (2012)
Journal Article

We measured behavioural performance and fMRI activity whilst old and young adults performed a temporal segmentation task (‘preview search’). Being able to select parts of the visual world to be attended or ignored is a critical visual skill. Both o... Read More about Similar behaviour, different brain patterns: age-related changes in neural signatures of ignoring.

Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems (2012)
Journal Article

In this article, we highlight an issue that arises when using multiple b?values in a model?based analysis of diffusion MR data for tractography. The non?monoexponential decay, commonly observed in experimental data, is shown to induce overfitting in... Read More about Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems.

The interaction of a vortex ring with a sloped sediment layer: critical criteria for incipient grain motion (2012)
Journal Article

Experiments were performed to analyse the interaction between a vortex ring and a sloped sediment layer. Attention focussed on interactions under “critical” conditions, in which sediment motion was only just induced by the ring's flow field. Both hyd... Read More about The interaction of a vortex ring with a sloped sediment layer: critical criteria for incipient grain motion.

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG (2012)
Journal Article

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overal... Read More about Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

Associations between udder health and reproductive performance in United Kingdom dairy cows (2012)
Journal Article

The objective of this research was to evaluate the relationship between udder health and reproductive performance in UK dairy cows. Data from 80 herds were restructured such that each unit of data represented a 2-d period during lactation where a cow... Read More about Associations between udder health and reproductive performance in United Kingdom dairy cows.

Evidence and belief in regulatory decisions – incorporating expected utility into decision modelling (2012)
Journal Article

Recent changes in the assessment and management of risks has had the effect that greater importance has been placed on relationships between individuals and within groups to inform decision making. In this paper, we provide the theoretical underpinni... Read More about Evidence and belief in regulatory decisions – incorporating expected utility into decision modelling.

A new sequential covering strategy for inducing classification rules with ant colony algorithms (2012)
Journal Article

Ant colony optimization (ACO) algorithms have been successfully applied to discover a list of classification rules. In general, these algorithms follow a sequential covering strategy, where a single rule is discovered at each iteration of the algorit... Read More about A new sequential covering strategy for inducing classification rules with ant colony algorithms.

In vivo confocal microscopic findings in patients with limbal stem cell deficiency (2012)
Journal Article

In vivo confocal microscopic features of normal limbus (2012)
Journal Article

Handedness and the excitability of cortical inhibitory circuits (2012)
Journal Article

Inhibitory processes play a significant role in the control of goal-directed actions. To increase insights into these mechanisms as a function of handedness, we measured the transient inhibition of volitional motor activity induced by single pulse tr... Read More about Handedness and the excitability of cortical inhibitory circuits.

The Veterinary Business Landscape: Contemporary Issues and Emerging Trends (2012)
Book Chapter

Investigation of the haemodynamic effects of exenatide in healthy male subjects (2012)
Journal Article

AIMS In clinical studies of glucagon-like peptide-1 (GLP-1) agonists used in the management of patients with type 2 diabetes, there is often a small accompanying fall in blood pressure. The mechanism underlying this effect is not known, although exen... Read More about Investigation of the haemodynamic effects of exenatide in healthy male subjects.

Evaluation of Rehabilitation of Memory in Neurological Disabilities (ReMiND): a randomized controlled trial (2012)
Journal Article

OBJECTIVE:The evidence for the effectiveness of memory rehabilitation is inconclusive. The aim was to compare the effectiveness of two group memory rehabilitation programmes with a self-help group control. DESIGN:Single-blind randomized controlled t... Read More about Evaluation of Rehabilitation of Memory in Neurological Disabilities (ReMiND): a randomized controlled trial.