All Outputs (348)

Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial (2010)
Journal Article

Pseudomonas aeruginosa forms biofilms in the cystic fibrosis lung. Quorum sensing (QS) controls biofilm maturation, immune evasion, antibiotic tolerance and virulence factor production. Garlic shows QS inhibitory activity in vitro and in animal model... Read More about Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial.

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy (2010)
Journal Article
Mistry, H., Kurlak, L., Williams, P., Ramsay, M., Symonds, M., & Broughton Pipkin, F. (2010). Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Placenta, 31(5), https://doi.org/10.1016/j.placenta.2010.02.011

Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality; it may also predispose the mother and fetus to increased risks of adult cardiovascular disease. The selenopr... Read More about Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy.

'They all supported me but I felt like I suddenly didn't belong anymore': An exploration of perceived disadvantages to online support seeking (2010)
Journal Article

In recent years, there has been a significant rise in the number of online support communities dedicated to issues surrounding infertility. The aim of this study was to focus on investigating the perceived disadvantages of online infertility support... Read More about 'They all supported me but I felt like I suddenly didn't belong anymore': An exploration of perceived disadvantages to online support seeking.

Case management for long-term conditions: Developing targeting processes (2010)
Journal Article

Intensive case management (ICM) is traditionally targeted atpatients with complex needs and exists within a wider service context. Targeting is integral to the efficiency of the service. A process and outcome evaluation of case management wasconducte... Read More about Case management for long-term conditions: Developing targeting processes.

The PAVE study (Physical Activity Virtual Education): development of reusable learning objects (RLOs) to enhance nursing students' knowledge and understanding of physical activity (2010)
Book Chapter
Blake, H., & Wharrad, H. (2010). The PAVE study (Physical Activity Virtual Education): development of reusable learning objects (RLOs) to enhance nursing students' knowledge and understanding of physical activity. In G. Baker, J. Falk-Whynes, & A. Sidorovitch (Eds.), Teaching for integrative learning. University of Nottingham. Centre for Integrative Learning

The aim of this project was to design, build and test two sustainable reusable learning objects (RLOs) for physical activity (PA) and provide opportunities to assess changes in knowledge and self-reported behaviour following exposure. The RLOs develo... Read More about The PAVE study (Physical Activity Virtual Education): development of reusable learning objects (RLOs) to enhance nursing students' knowledge and understanding of physical activity.

Waiting times for radiotherapy after breast cancer (2010)
Journal Article

Towards modelling cost and risks of infrequent events in the cargo screening process (2010)
Conference Proceeding

We introduce a simulation model of the port of Calais with a focus on the operation of immigration controls. Our aim is to compare the cost and benefits of different screening policies. Methodologically, we are trying to understand the limits of disc... Read More about Towards modelling cost and risks of infrequent events in the cargo screening process.

A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients (2010)
Journal Article
Soria, D., Garibaldi, J. M., Ambrogi, F., Green, A. R., Powe, D., Rakha, E., …Ellis, I. O. (2010). A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients. Computers in Biology and Medicine, 40(3), https://doi.org/10.1016/j.compbiomed.2010.01.003

Single clustering methods have often been used to elucidate clusters in high dimensional medical data, even though reliance on a single algorithm is known to be problematic. In this paper, we present a methodology to determine a set of ‘core classes’... Read More about A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients.

Carbon gold rush and carbon cowboys: a new chapter in green mythology? (2010)
Journal Article
Nerlich, B., & Koteyko, N. (2010). Carbon gold rush and carbon cowboys: a new chapter in green mythology?. Environmental Communication, 4(1), https://doi.org/10.1080/17524030903522389

Individual and collective efforts to mitigate climate change in the form of carbon offsetting and emissions trading schemes have recently become the focus of much media attention. In this paper we explore a subset of the UK national press coverage ce... Read More about Carbon gold rush and carbon cowboys: a new chapter in green mythology?.

Adaptivity and a posteriori error control for bifurcation problems II: Incompressible fluid flow in open systems with Z_2 symmetry (2010)
Journal Article
Cliffe, A., Hall, E., Houston, P., Phipps, E. T., & Salinger, A. G. Adaptivity and a posteriori error control for bifurcation problems II: Incompressible fluid flow in open systems with Z_2 symmetry. Manuscript submitted for publication

In this article we consider the a posteriori error estimation and adaptive mesh refinement of discontinuous Galerkin finite element approximations of the bifurcation problem associated with the steady incompressible Navier-Stokes equations. Particula... Read More about Adaptivity and a posteriori error control for bifurcation problems II: Incompressible fluid flow in open systems with Z_2 symmetry.

Behavioural correlation for detecting P2P bots (2010)
Book Chapter
Al-Hammadi, Y., & Aickelin, U. (2010). Behavioural correlation for detecting P2P bots. In Second International Conference on Future Networks, 2010: ICFN '10. IEEE. https://doi.org/10.1109/ICFN.2010.72

In the past few years, IRC bots, malicious programs which are remotely controlled by the attacker through IRC servers, have become a major threat to the Internet and users. These bots can be used in different malicious ways such as issuing distri... Read More about Behavioural correlation for detecting P2P bots.

From carbon markets to carbon morality: creative compounds as framing devices in online discourses on climate change mitigation (2010)
Journal Article
Koteyko, N., Thelwall, M., & Nerlich, B. (2010). From carbon markets to carbon morality: creative compounds as framing devices in online discourses on climate change mitigation. Science Communication, 32(1), https://doi.org/10.1177/1075547009340421

Lexical combinations of at least two roots around "carbon" as the hub, such as "carbon finance" or "carbon footprint," have recently become ubiquitous in English-speaking science, politics, and mass media. They are part of a new language evolving aro... Read More about From carbon markets to carbon morality: creative compounds as framing devices in online discourses on climate change mitigation.

Introduction: doing rural cultural studies (2010)
Journal Article
Evers, C., Gorman-Murray, A., & Potter, E. (2010). Introduction: doing rural cultural studies. Cultural Studies Review, 16(1), https://doi.org/10.5130/csr.v16i1.1451

Pneumonia and influenza: specific considerations in care homes (2010)
Journal Article
Gordon, A., & Ewan, V. (2010). Pneumonia and influenza: specific considerations in care homes. Reviews in Clinical Gerontology, 20(1), 69-80. https://doi.org/10.1017/S0959259810000043

This review provides an update on current evidence surrounding epidemiology, treatment and prevention of lower respiratory tract infection, with special reference to pneumonia and influenza, in care home residents. The care home sector is growing an... Read More about Pneumonia and influenza: specific considerations in care homes.

Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists (2010)
Journal Article
Katritch, V., Jaakola, V., Lane, J. R., Lin, J., Ijzerman, A. P., Yeager, M., …Abagyan, R. (2010). Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists. Journal of Medicinal Chemistry, 53(4), 1799-1809. https://doi.org/10.1021/jm901647p

The recent progress in crystallography of G-protein coupled receptors opens an unprecedented venue for structure-based GPCR drug discovery. To test efficiency of the structure-based approach, we performed molecular docking and virtual ligand screenin... Read More about Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists.

Are we teaching our students what they need to know about ageing? Results from the National Survey of Undergraduate Teaching in Ageing and Geriatric Medicine (2010)
Journal Article
Gordon, A., Blundell, A. G., Gladman, J. R., & Masud, T. (2010). Are we teaching our students what they need to know about ageing? Results from the National Survey of Undergraduate Teaching in Ageing and Geriatric Medicine. Age and Ageing, 29(3), https://doi.org/10.1093/ageing/afq011

Introduction - Learning about ageing and the appropriate management of older patients is important for all doctors. This survey set out to evaluate what medical undergraduates in the UK are taught about ageing and geriatric medicine and how this tea... Read More about Are we teaching our students what they need to know about ageing? Results from the National Survey of Undergraduate Teaching in Ageing and Geriatric Medicine.

Cerebral misery perfusion diagnosed using hypercapnic blood-oxygenation-level-dependent contrast functional magnetic resonance imaging: a case report (2010)
Journal Article
Gordon, A. L., Goode, S., D'Souza, O., Auer, D. P., & Munshi, S. K. (2010). Cerebral misery perfusion diagnosed using hypercapnic blood-oxygenation-level-dependent contrast functional magnetic resonance imaging: a case report. Journal of Medical Case Reports, 4(1), https://doi.org/10.1186/1752-1947-4-54

Introduction Cerebral misery perfusion represents a failure of cerebral autoregulation. It is animportant differential diagnosis in post-stroke patients presenting with collapses in the presence of haemodynamically significant cerebrovascular stenos... Read More about Cerebral misery perfusion diagnosed using hypercapnic blood-oxygenation-level-dependent contrast functional magnetic resonance imaging: a case report.

5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors (2010)
Journal Article

Fluorescence polarization using Nα-(fluorescein-5- carbonyl)-Nε-(N-[2-fluoro-4-iodophenyl]-3,4- difluoroanthraniloyl)lysyl amide is capable of rapidly identifying inhibitor ligands that bind to an allosteric site in MEK1. © The Royal Society of Chemi... Read More about 5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors.

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues (2010)
Journal Article
Jaakola, V., Lane, J. R., Lin, J. Y., Katritch, V., Ijzerman, A. P., & Stevens, R. C. (2010). Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues. Journal of Biological Chemistry, 285(17), 13032-13044. https://doi.org/10.1074/jbc.M109.096974

The crystal structure of the human A(2A) adenosine receptor bound to the A(2A) receptor-specific antagonist, ZM241385, was recently determined at 2.6-A resolution. Surprisingly, the antagonist binds in an extended conformation, perpendicular to the p... Read More about Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues.

Coping with infertility online: An examination of self-help mechanisms in an online infertility support group (2010)
Journal Article

Objective: To examine communication within an online infertility support group. Methods: A content analysis of 3500 messages posted to infertility bulletin boards. Results: The most frequently used self-help mechanisms were support or empathy (45.5%)... Read More about Coping with infertility online: An examination of self-help mechanisms in an online infertility support group.