All Outputs (228)

DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact (2007)
Journal Article

PDZ domain containing molecular scaffolds plays a central role in organizing synaptic junctions. Observations in Drosophila and mammalian cells have implicated that ubiquitination and endosomal trafficking, of molecular scaffolds are critical to the... Read More about DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

A bidomain threshold model of propagating calcium waves (2007)
Journal Article

We present a bidomain fire-diffuse-fire model that facilitates mathematical analysis of propagating waves of elevated intracellular calcium (Ca) in living cells. Modelling Ca release as a threshold process allows the explicit construction of travell... Read More about A bidomain threshold model of propagating calcium waves.

The anthelmintic efficacy of plant-derived cysteine proteinases against the rodent gastrointestinal nematode, Heligmosomoides polygyrus, in vivo (2007)
Journal Article

Gastrointestinal (GI) nematodes are important disease-causing organisms, controlled primarily through treatment with synthetic drugs, but the efficacy of these drugs has declined due to widespread resistance, and hence new drugs, with different modes... Read More about The anthelmintic efficacy of plant-derived cysteine proteinases against the rodent gastrointestinal nematode, Heligmosomoides polygyrus, in vivo.

Controlling Pattern Formation in Nanoparticle Assemblies via Directed Solvent Dewetting (2007)
Journal Article

We have achieved highly localised control of pattern formation in two dimensional nanoparticle assemblies by direct modification of solvent dewetting dynamics. A striking dependence of nanoparticle organisation on the size of atomic force microscope-... Read More about Controlling Pattern Formation in Nanoparticle Assemblies via Directed Solvent Dewetting.

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat I: no decrease in epididymal sperm count after a single acute dose (2007)
Journal Article

It has been reported that fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat. We set out to replicate and extend these effects using a robust experimental design. Groups of 75 (contr... Read More about Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat I: no decrease in epididymal sperm count after a single acute dose.

New Ways of Working in Acute Care: A Case for Change (2007)
Journal Article

This position paper focuses on the current tensions and challenges of aligning inpatient care with innovations in mental health services. It argues that a cultural shift is required within inpatient services. Obstacles to change including traditional... Read More about New Ways of Working in Acute Care: A Case for Change.

DLGH1 is a negative regulator of T-lymphocyte proliferation (2007)
Journal Article

Discs large homolog 1 (DLGH1), a founding member of the membrane-associated guanylate kinase family of proteins containing Postsynaptic Density-95/Discs large/Zona Occludens-1 domains, is an ortholog of the Drosophila tumor suppressor gene Discs larg... Read More about DLGH1 is a negative regulator of T-lymphocyte proliferation.

Particle transfer in braneworld collisions (2007)
Journal Article

We study the behaviour of fermions localized on moving kinks as these collide with either antikinks or spacetime boundaries. We numerically solve for the evolution of the scalar kinks and the bound (i.e. localized) fermion modes, and calculate the nu... Read More about Particle transfer in braneworld collisions.

Rice pseudomolecule-anchored cross-species DNA sequence alignments indicate regional genomic variation in expressed sequence conservation (2007)
Journal Article

Background Various methods have been developed to explore inter-genomic relationships among plant species. Here, we present a sequence similarity analysis based upon comparison of transcript-assembly and methylation-filtered databases from five plan... Read More about Rice pseudomolecule-anchored cross-species DNA sequence alignments indicate regional genomic variation in expressed sequence conservation.

Encountering competitors reduces clutch size and increases offspring size in a parasitoid with female–female fighting (2007)
Journal Article

Understanding the size of clutches produced by only one parent may require a game-theoretic approach: clutch size may affect offspring fitness in terms of future competitive ability. If larger clutches generate smaller offspring and larger adults are... Read More about Encountering competitors reduces clutch size and increases offspring size in a parasitoid with female–female fighting.

Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study (2007)
Journal Article

There is debate over the mortality and malignancy risk in people with primary biliary cirrhosis (PBC) and whether this risk is reduced by use of ursodeoxycholic acid. To investigate this issue, we identified 930 people with PBC and 9,202 control subj... Read More about Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study.

Novel pharmacological applications of G-protein-coupled receptor-G protein fusions (2007)
Journal Article

Single, bi-functional polypeptides consisting of a G-protein-coupled receptor (GPCR) linked directly to a G protein alpha subunit have been employed for a number of years to study many aspects of signal initiation, including the roles of post-transla... Read More about Novel pharmacological applications of G-protein-coupled receptor-G protein fusions.

NF-?B activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations (2007)
Journal Article

Hippocampal memory-associated synaptic plasticity is driven by a cascade of transcription and new protein synthesis. In vitro electrophysiological studies on acute hippocampal slices have elucidated much of what we know about this molecular cascade.... Read More about NF-?B activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations.

Effect of maternal undernutrition on ruminant carcass and meat quality (2007)
Journal Article

We have previously shown that, in sheep, the majority of muscle differentiation and fibre formation takes place around d85 of gestation, with myoblast proliferation occurring before this time (FAHEY et al., 2005a). In a second study (FAHEY et al., 20... Read More about Effect of maternal undernutrition on ruminant carcass and meat quality.

Exploring the ionization state of the intergalactic medium with Lyman-alpha absorption (2007)
Other

Just choices: Representations of choice and coercion in sex work in Cambodia (2007)
Journal Article

In global discourses about sex work, the image of the 'sex slave' has been influential in constructing the view of women working in the sex industry in developing countries as 'victims'. This paper examines the perpetuation of such discourses through... Read More about Just choices: Representations of choice and coercion in sex work in Cambodia.

Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats (2007)
Journal Article

This study assessed the impact of reduced dietary protein during specific periods of fetal life upon muscle fibre development in young rats. Pregnant rats were fed a control or low-protein (LP) diet at early (days 0-7 gestation, LPEarly), mid (days 8... Read More about Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats.

Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction (2007)
Journal Article

Seasonal adaptations in physiology exhibited by many animals involve an interface between biological timing and specific neuroendocrine systems, but the molecular basis of this interface is unknown. In this study of Siberian hamsters, we show that th... Read More about Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction.

VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters (2007)
Journal Article

The Siberian hamster survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. VGF gene expression is photoperiodically regulated in the hypothalamus with significantly... Read More about VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters.

‘Relational Marketplaces’ and the Rise of Boutiques in London's Corporate Finance Industry (2007)
Journal Article

In this paper I examine the rise of corporate finance boutiques in London's financial district from the early 2000s onwards. These small firms, typically employing no more than 25 people, specialise in a single corporate finance client sector (such a... Read More about ‘Relational Marketplaces’ and the Rise of Boutiques in London's Corporate Finance Industry.