Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein

Owsianka, Ania; Tarr, Alexander W.; Juttla, Vicky S.; Lavillette, Dimitri; Bartosch, Birke; Cosset, François Loïc; Ball, Jonathan K.; Patel, Arvind H.

doi:10.1128/JVI.79.17.11095-11104.2005

Place, policy and practitioners: on rehabilitation, independence and the therapeutic landscape in the changing geography of care provision to older people in the United Kingdom (2005)
Journal Article

A growing body of literature in geography and other social sciences considers the role of place in the provision of healthcare. Authors have focused on various aspects of place and care, with particular interests emerging around the role of the psych... Read More about Place, policy and practitioners: on rehabilitation, independence and the therapeutic landscape in the changing geography of care provision to older people in the United Kingdom.

Total loss of MHC class I is an independent indicator of good prognosis in breast cancer (2005)
Journal Article

Tumours can be recognised by CTL and NK cells. CTL recognition depends on expression of MHC Class I loaded with peptides from tumour antigens. In contrast, loss of MHC Class I results in NK activation. In our study a large set of samples from patient... Read More about Total loss of MHC class I is an independent indicator of good prognosis in breast cancer.

Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens (2005)
Journal Article

Colonization of broiler chickens by the enteric pathogen Campylobacter jejuni is widespread and difficult to prevent. Bacteriophage therapy is one possible means by which this colonization could be controlled, thus limiting the entry of campylobacter... Read More about Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens.

Time-dependent surface reactivity of Cd sorbed on calcite, hydroxylapatite and humic acid (2005)
Journal Article

Changes in the lability and local environment of Cd sorbed onto calcite, hydroxylapatite and humic acid have been investigated as a function of time (30 min–9 months) using a combination of X-ray adsorption spectroscopy (XAS) and isotopic dilution te... Read More about Time-dependent surface reactivity of Cd sorbed on calcite, hydroxylapatite and humic acid.

Time-dependent surface reactivity of Cd sorbed on calcite, hydroxylapatite and humic acid (2005)
Journal Article

Community Care: Service Delivery, Development and Evaluation (2005)
Book Chapter

Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus (2005)
Journal Article

The number of muscle fibers within a muscle has been found to be of high importance for the growth potential of an animal, and this number is set during fetal development. The objective of this study was to identify the ontogeny of muscle cell differ... Read More about Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus.

Queering religious texts: An exploration of British non-heterosexual Christians’ and Muslims’ strategy of constructing sexuality-affirming hermeneutics. (2005)
Journal Article

Religious authority figures often use religious texts as the primary basis for censuring homosexuality. In recent years, however, non-heterosexual Christians and Muslims have begun to contest the discursively produced boundary of sexual morality.Draw... Read More about Queering religious texts: An exploration of British non-heterosexual Christians’ and Muslims’ strategy of constructing sexuality-affirming hermeneutics..

New Ways of Working for Psychiatrists: Enhancing Effective, Person Centred Services through New Ways of Working in Multidisciplinary and Mulit-agency Contexts (2005)
Book

A coupled calibration and modelling approach to the understanding of dry-land lake oxygen isotope records (2005)
Journal Article

Comparisons between climate proxies and instrumental records through the last two centuries are often used to understand better the controls on palaeoarchives and to find relationships that can be used to quantify changes in pre-instrumental climate.... Read More about A coupled calibration and modelling approach to the understanding of dry-land lake oxygen isotope records.

Digalactoside expression in the lipopolysaccharide of haemophilus influenzae and its role in intravascular survival (2005)
Journal Article

Digalactoside (gal-1-4 gal) structures of the lipopolysaccharide (LPS) of Haemophilus influenzae are implicated in virulence. A confounding factor is that tetranucleotide repeats within the lic2A, lgtC, and lex2 genes mediate phase-variable expressio... Read More about Digalactoside expression in the lipopolysaccharide of haemophilus influenzae and its role in intravascular survival.

Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex (2005)
Journal Article

Using intracellular cytokine staining we show herein that T cells will respond to short-term (6 h) activation with phorbol ester plus ionomycin by production of tumor necrosis factor (TNF), IFN-γ or both. Here CD4 T cells preferentially produce TNF a... Read More about Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex.

Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV (2005)
Journal Article

In this work, new putative epitopes located in nonstructural proteins of GBV-C/HGV were synthesized using solid-phase chemistry for their use in immunoassays. The antigens were obtained in linear, chimeric and cyclic forms with the main aim of improv... Read More about Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV.

The evolution of imperfect mimicry (2005)
Book Chapter

Ideas about the evolution of imperfect mimicry are reviewed. Their relevance to the colours patterns of hoverflies (Diptera, Syrphidae) are discussed in detail. Most if not all of the hoverflies labelled as mimetic actually are mimics. The apparent... Read More about The evolution of imperfect mimicry.

Stages of change and consumption of fruit and vegetables among adolescent females: Associations with decisional balance and self-efficacy (2005)
Journal Article

Purpose The aim of this study was to apply key theoretical constructs from the Transtheoretical Model to daily consumption of at least five portions of fruit and vegetables among adolescent females. Design/methodology/approach A self?report... Read More about Stages of change and consumption of fruit and vegetables among adolescent females: Associations with decisional balance and self-efficacy.

The geometry of certain cocycles associated to derivatives of L-functions (2005)
Journal Article

Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets (2005)
Journal Article

Hepatitis C virus (HCV) binding to hepatocytes is thought to be mediated via interaction of the E2 glycoprotein with (co-)receptors including CD81 and scavenger receptor class B type I (SR-BI). Here, the expression of CD81 and SR-BI was analysed on p... Read More about Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets.

Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein (2005)
Journal Article

Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines. Here, we describe the generation of retrovirus-based p... Read More about Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein.

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