All Outputs (209)

On the origins of phenotypic parallelism in benthic and limnetic stickleback (2022)
Working Paper

Rapid evolution of similar phenotypes in similar environments, giving rise to in situ parallel adaptation, is an important hallmark of ecological speciation. However, what appears to be in situ adaptation can also arise by dispersal of divergent line... Read More about On the origins of phenotypic parallelism in benthic and limnetic stickleback.

‘It Means We are Not Safe’: Understanding and Learning from Household Experiences of Water Scarcity, Flood and Fire in Marginalized Settlements in the Cape Flats, South Africa (2022)
Working Paper

As climate change-related extreme weather events such as flooding and droughts increase in frequency and severity in most cities worldwide, there is a need to deepen understanding of disaster risks and adaptive capacities. A significant percentage of... Read More about ‘It Means We are Not Safe’: Understanding and Learning from Household Experiences of Water Scarcity, Flood and Fire in Marginalized Settlements in the Cape Flats, South Africa.

Just Transition: Pathways to Socially Inclusive Decarbonisation (2022)
Working Paper

Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast (2022)
Working Paper

Here we report the design, construction and characterization of a tRNA neochromosome, a designer chromosome that functions as an additional, de novo counterpart to the native complement of Saccharomyces cerevisiae. Intending to address one of the cen... Read More about Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast.

Test@Work Texts: Mobile Phone Messaging to Increase Awareness of HIV and HIV Testing in UK Construction Employees During the COVID-19 Pandemic (2022)
Working Paper

Background: HIV poses a threat to global health. With effective treatment options available, education and testing strategies are essential in preventing transmission. Text messaging is an effective tool for health promotion and can be used to target... Read More about Test@Work Texts: Mobile Phone Messaging to Increase Awareness of HIV and HIV Testing in UK Construction Employees During the COVID-19 Pandemic.

Fade in, fade out: Do shifts in visual perspective predict the consistency of real-world memories? (2022)
Working Paper

Memories of our personal past are not exact accounts of what occurred. Instead, memory reconstructs the past in adaptive–though not always faithful–ways. Using a naturalistic design, here we asked how the visual perspective adopted in the mind’s eye... Read More about Fade in, fade out: Do shifts in visual perspective predict the consistency of real-world memories?.

Organoruthenium Complexes Containing Hemilabile Phosphinodicarboxamide Ligands (2022)
Working Paper

Ruthenium complexes of hemilabile phosphinocarboxamide ligands, and their use to form metallacycles using halide abstraction/deprotonation reactions are reported. Thus, [Ru(p-cym){PPh2C(=O)NHR}Cl2; R = iPr (1), Ph (2), p-tol (3)] and [Ru(p-cym){PPh2C... Read More about Organoruthenium Complexes Containing Hemilabile Phosphinodicarboxamide Ligands.

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection (2022)
Working Paper

Background Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve understanding o... Read More about Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.

Enhancement of Syngas Production in Co-Pyro-Gasification of Biomass and Plastic Waste Materials: Computational Study (2022)
Working Paper

The process of co-pyro-gasification of biomass and plastics appears to have the potential for increasing syngas production for power generation and thus minimizing the impact of plastic waste on the environment. This study was based on co-pyro-gasifi... Read More about Enhancement of Syngas Production in Co-Pyro-Gasification of Biomass and Plastic Waste Materials: Computational Study.

Undirected, Pd-catalysed deuteration of indoles with programmable regioselectivity (2022)
Working Paper

Methods for selective deuterium-incorporation into drug-like molecules have become extremely valuable due to the commercial and biological importance of deuterated compounds. Selective C2-deuteration of indoles currently requires the installation of... Read More about Undirected, Pd-catalysed deuteration of indoles with programmable regioselectivity.

Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand (2022)
Working Paper

We describe construction of the 660 kilobase synthetic yeast chromosome XI (synXI) and reveal how synthetic redesign of non-coding DNA elements impact the cell. To aid construction from synthesized 5 to 10 kilobase DNA fragments, we implemented CRISP... Read More about Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand.

White Matter Microstructural Alteration in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging (2022)
Working Paper

Background: Type 2 diabetes mellitus impacts the brain microstructural environment. Diffusion tensor imaging (DTI) has been widely used to characterize white matter microstructural abnormalities in type 2 diabetes but fails to fully characterise dise... Read More about White Matter Microstructural Alteration in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging.

Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites (2022)
Working Paper

As our understanding of disease grows, it is becoming established that treatment needs to be personalized and targeted to the needs of the individual. In this paper we show that multi-material inkjet-based 3D printing, when backed with generative des... Read More about Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites.

The Impact of Covid-19 on Productivity (2022)
Working Paper

We analyse the impact of Covid-19 on productivity using data from an innovative monthly firm survey panel that asks for quantitative impacts of Covid on inputs and outputs. We find total factor productivity (TFP) fell by up to 5% during 2020-21. The... Read More about The Impact of Covid-19 on Productivity.

Laboratory strains of Escherichia coli K-12: not such perfect role models after all (2022)
Working Paper

Escherichia coli K-12 was originally isolated 100 years ago and since then, it has become an invaluable model organism and a cornerstone of molecular biology research. However, despite its apparent pedigree, since its initial isolation, E. coli K-12... Read More about Laboratory strains of Escherichia coli K-12: not such perfect role models after all.

Understanding Trust and Sustained Use or Abandonment after a Year with the NHS Covid-19 Contact Tracing App in the United Kingdom: A Longitudinal Mixed-Method Study (2022)
Working Paper

Background: Digital contact tracing (DCT) apps have been recently implemented widely as a response to the Covid-19 pandemic. Research has focused on understanding the acceptance and adoption of these apps, but more work is needed to understand which... Read More about Understanding Trust and Sustained Use or Abandonment after a Year with the NHS Covid-19 Contact Tracing App in the United Kingdom: A Longitudinal Mixed-Method Study.

The Centre for Rehabilitation and Ageing Research in Nottingham and Derby 2022. Excellence in care through world class research (2022)
Working Paper

It is with pleasure that we present this brochure outlining the work of the Centre for Rehabilitation and Ageing and Research (CRAR) at the University of Nottingham and its partner NHS Trusts in Nottingham, and Derby and Burton.

Navigating Incommensurability Between Ethnomethodology, Conversation Analysis, and Artificial Intelligence (2022)
Working Paper

Like many research communities, ethnomethodologists and conversation analysts have begun to get caught up -- yet again -- in the pervasive spectacle of surging interests in Artificial Intelligence (AI). Inspired by discussions amongst a growing netwo... Read More about Navigating Incommensurability Between Ethnomethodology, Conversation Analysis, and Artificial Intelligence.

NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022 (2022)
Working Paper

This paper gives summaries of the keynote lectures given and the research abstracts presented at the NIHR Nottingham Biomedical Research Centre Musculoskeletal theme virtual conference held on 24th and 25th February 2022. The purpose of the confere... Read More about NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022.

'Queer/ing China': Theorizing Chinese genders and sexualities through a transnational lens (2022)
Working Paper

In this viewpoint essay, using ‘queer/ing China’ as a heuristic, we explore ‘queerness’ and ‘Chineseness’ through an intersectional approach that is attuned to the encounters, syntheses and dissonances of local, transnational and global queer and fem... Read More about 'Queer/ing China': Theorizing Chinese genders and sexualities through a transnational lens.