All Outputs (32)
Reduced inhibitory GABA function, so-called neural disinhibition, has been implicated in cognitive disorders, including schizophrenia and age-related cognitive decline. We previously showed in rats that hippocampal disinhibition by local microinfusio... Read More about Frequency- and state-dependent effects of hippocampal neural disinhibition on hippocampal local field potential oscillations in anaesthetised rats.
Background: Remote measurement technologies (RMTs) can be used to collect data on a variety of bio-behavioural variables, which may benefit the care of people with central nervous system disorders. While various studies have explored their potential... Read More about Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint).
Background: Knowledge of hearing aids in adults living with hearing loss is highly variable, resulting in suboptimal or non-use. This issue can be addressed by the provision of high-quality educational information. Objective: This study assesse... Read More about Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study.
Two Receptor-Like Kinases Required For Arabidopsis Endodermal Root Organisation Shape The Rhizosphere Microbiome (2019)
Other
The Casparian Strip (CS) constitutes a physical diffusion barrier to water and nutrients in plant roots, and is formed by the polar deposition of lignin polymer in the endodermis. This precise pattern of lignin deposition is thought to be mediated by... Read More about Two Receptor-Like Kinases Required For Arabidopsis Endodermal Root Organisation Shape The Rhizosphere Microbiome.
Selection-based model of prokaryote pangenomes (2019)
Other
Horizon is a Research Institute centred at The University of Nottingham and a Research Hub within the UKRI Digital Economy programme. Horizon brings together researchers from a broad range of disciplines to investigate the opportunities and challenge... Read More about Response To ICO Consultation On The Draft Framework Code Of Practice For The Use Of Personal Data In Political Campaigning.
Nuclear poly(A) tail size is regulated by Cnot1 during the serum response (2019)
Other
The poly(A) tail removal from mRNAs introduces a delay between mRNA synthesis and decay. We measured levels and poly(A) tail sizes of serum-induced mRNAs and used mathematical modelling to compare their deadenylation time with the delay in decay and... Read More about Nuclear poly(A) tail size is regulated by Cnot1 during the serum response.
Horizon is a Research Institute centred at The University of Nottingham and a Research Hub within the UKRI Digital Economy programme. Horizon brings together researchers from a broad range ofdisciplines to investigate the opportunities and challenges... Read More about Response To The Governments Consultation Smart Data Putting Consumers In Control Of Their Data And Enabling Innovation.
The neural bases of resilient cognitive systems: Evidence of variable neuro-displacement in the semantic system (2019)
Other
The purpose of this study was to initiate exploration of an equally-important research goal: what are the neurocomputational mechanisms that make these cognitive systems “well engineered” and thus resilient across a range of performance demands and t... Read More about The neural bases of resilient cognitive systems: Evidence of variable neuro-displacement in the semantic system.
Energy efficient synaptic plasticity (2019)
Other
Many aspects of the brain’s design can be understood as the result of evolutionary drive towards efficient use of metabolic energy. In addition to the energetic costs of neural computation and transmission, experimental evidence indicates that synapt... Read More about Energy efficient synaptic plasticity.
Root development is maintained by specific bacteria-bacteria interactions within a complex microbiome (2019)
Other
Plants grow within a complex web of species interacting with each other and with the plant via a wide repertoire of chemical signals. To model plant-microbe-microbe-environment interactions, we inoculated seedlings with a defined 185-member bacterial... Read More about Root development is maintained by specific bacteria-bacteria interactions within a complex microbiome.
Hormone replacement therapy (HRT) is used to help women suffering from menopausal symptoms and reduce risk of osteoporosis. Although effective, the therapy may lead to an increased risk of breast cancer. Previous studies have not been powerful enou... Read More about Protocol to assess risk of breast cancer associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care..