The neural bases of resilient cognitive systems: Evidence of variable neuro-displacement in the semantic system

Jung, JeYoung; Rice, Grace E.; Lambon Ralph, Matthew A.

Abstract

The purpose of this study was to initiate exploration of an equally-important research goal: what are the neurocomputational mechanisms that make these cognitive systems “well engineered” and thus resilient across a range of performance demands and to mild levels of perturbation or even damage? We achieved this aim by investigating the neural dynamics of the semantic network with two task difficulty manipulations. We found that intrinsic resilience-related mechanisms were observed in both the domain-specific semantic representational system and the parallel executive control networks. Functional connectivity between these regions was also increased and these increases were related to better semantic task performance. Our results suggest that higher cognitive functions are made resilient by flexible, dynamic changes (variable neuro-displacement) across both domain-specific and multi-demand networks. Our findings provide strong evidence that the compensatory functional alterations in the impaired brain might reflect intrinsic mechanisms of a well-engineered neural system.

Citation

Jung, J., Rice, G. E., & Lambon Ralph, M. A. The neural bases of resilient cognitive systems: Evidence of variable neuro-displacement in the semantic system

• Other Type: Other
• Deposit Date: May 22, 2020
• Publicly Available Date: May 27, 2020
• DOI: https://doi.org/10.1101/716266
• Public URL: https://nottingham-repository.worktribe.com/output/3794499
• Additional Information: This is a bioRxiv preprint.