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Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave (2024)
Journal Article
Acheampong, E., Husain, A. A., Dudani, H., Nayak, A. R., Nag, A., Meena, E., …Monaghan, T. M. (in press). Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave. PLoS ONE,

Wastewater-based epidemiology (WBE) has emerged as an effective environmental surveillance tool for predicting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease outbreaks in high-income countries (HICs) with centralized sewage infr... Read More about Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave.

Promoter methylation leads to Hepatocyte Nuclear Factor 4A loss and pancreatic cancer aggressiveness (2024)
Journal Article
Hatziapostolou, M., Koutsioumpa, M., Zaitoun, A. M., Polytarchou, C., Edderkaoui, M., Mahurkar-Joshi, S., …Iliopoulos, D. (in press). Promoter methylation leads to Hepatocyte Nuclear Factor 4A loss and pancreatic cancer aggressiveness. Gastro Hep Advances, https://doi.org/10.1016/j.gastha.2024.04.005

Background and Aims Efforts to decode pancreatic ductal adenocarcinoma (PDAC) heterogeneity and the consequent therapeutic selection remains a challenge. We aimed to characterize epigenetically regulated pathways involved in PDAC progression. Met... Read More about Promoter methylation leads to Hepatocyte Nuclear Factor 4A loss and pancreatic cancer aggressiveness.

Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient (2024)
Journal Article
Rivers, G., Lion, A., Rofiqoh Eviana Putri, N., Rance, G., Moloney, C., Taresco, V., …He, Y. (in press). Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient. Materials Today Advances,

Additive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing e... Read More about Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient.

New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo (2024)
Journal Article
Traserra, S., Alcalá-González, L. G., Barber, C., Landolfi, S., Malagelada, C., Lange, R., …Jimenez, M. (2024). New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo. European Journal of Pharmacology, 972, Article 176550. https://doi.org/10.1016/j.ejphar.2024.176550

Introduction: Hyoscine butylbromide (HBB) is one of the most used antispasmodics in clinical practice. Recent translational consensus has demonstrated a similarity between human colonic motor patterns studied ex vivo and in vivo, suggesting ex vivo c... Read More about New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo.

Increased Anti-Inflammatory Therapeutic Potential and Progenitor Marker Expression of Corneal Mesenchymal Stem Cells Cultured in an Optimized Propagation Medium (2024)
Journal Article
Hopkinson, A., Notara, M., Cursiefen, C., & Sidney, L. E. (2024). Increased Anti-Inflammatory Therapeutic Potential and Progenitor Marker Expression of Corneal Mesenchymal Stem Cells Cultured in an Optimized Propagation Medium. Cell Transplantation, 33, 1-17. https://doi.org/10.1177/09636897241241992

There is a huge unmet need for new treatment modalities for ocular surface inflammatory disorders (OSIDs) such as dry eye disease and meibomian gland dysfunction. Mesenchymal stem cell therapies may hold the answer due to their potent immunomodulator... Read More about Increased Anti-Inflammatory Therapeutic Potential and Progenitor Marker Expression of Corneal Mesenchymal Stem Cells Cultured in an Optimized Propagation Medium.

Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value (2024)
Journal Article
Alhudiri, I., Nolan, C., Ellis, I., Elzagheid, A., Green, A., & Chapman, C. (2024). Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value. Breast Cancer Research and Treatment, https://doi.org/10.1007/s10549-024-07293-y

Purpose Cathepsin D is a proteolytic enzyme that is normally localized in the lysosomes and is involved in the malignant progression of breast cancer. There are conflicting results regarding Cathepsin D significance as prognostic and predictor marke... Read More about Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value.

Case Series: Efficacy of Polyclonal Intravenous Immunoglobulin for Refractory Clostridioides difficile Infection (2024)
Journal Article
Ragan, S. A., Doyle, C., Datta, N., Abdic, H., Wilcox, M. H., Montgomery, R., …Monaghan, T. M. (2024). Case Series: Efficacy of Polyclonal Intravenous Immunoglobulin for Refractory Clostridioides difficile Infection. Antibodies, 13(2), Article 26. https://doi.org/10.3390/antib13020026

Background: Intravenous immunoglobulin (IVIg) for Clostridioides difficile infection (CDI) no longer features in treatment guidelines. However, IVIg is still used by some clinicians for severe or recurrent CDI (rCDI) cases. The main objective of this... Read More about Case Series: Efficacy of Polyclonal Intravenous Immunoglobulin for Refractory Clostridioides difficile Infection.

The Clinicopathological Significance of the Cyclin D1/E1–Cyclin-Dependent Kinase (CDK2/4/6)–Retinoblastoma (RB1/pRB1) Pathway in Epithelial Ovarian Cancers (2024)
Journal Article
Lashen, A., Algethami, M., Alqahtani, S., Shoqafi, A., Sheha, A., Jeyapalan, J. N., …Madhusudan, S. (2024). The Clinicopathological Significance of the Cyclin D1/E1–Cyclin-Dependent Kinase (CDK2/4/6)–Retinoblastoma (RB1/pRB1) Pathway in Epithelial Ovarian Cancers. International Journal of Molecular Sciences, 25(7), Article 4060. https://doi.org/10.3390/ijms25074060

Cyclin-dependent kinases (CDK2, CDK4, CDK6), cyclin D1, cyclin E1 and phosphorylated retinoblastoma (pRB1) are key regulators of the G1/S cell cycle checkpoint and may influence platinum response in ovarian cancers. CDK2/4/6 inhibitors are emerging t... Read More about The Clinicopathological Significance of the Cyclin D1/E1–Cyclin-Dependent Kinase (CDK2/4/6)–Retinoblastoma (RB1/pRB1) Pathway in Epithelial Ovarian Cancers.

National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study (2024)
Journal Article
Colby, E., Hayward, S., Benavente, M., Robertson, F., Bierzynska, A., Osborne, A., …Saleem, M. A. (2024). National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study. Clinical Kidney Journal, https://doi.org/10.1093/ckj/sfae096

Background Idiopathic Nephrotic Syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS coho... Read More about National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study.

Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis (2024)
Journal Article
Viramontes-Hörner, D., Selby, N. M., & Taal, M. W. (2024). Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis. Kidney International Reports, https://doi.org/10.1016/j.ekir.2024.03.020

Introduction: Elevated skin autofluorescence (SAF), a measure of tissue accumulation of advanced glycation end products (AGEs), is a strong predictor of all-cause and cardiovascular mortality in the hemodialysis population. However, prospective studi... Read More about Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis.

Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data (2024)
Journal Article
Kolhe, N. V., Fluck, R. J., & Taal, M. W. (in press). Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data. BMC Infectious Diseases, 24(1), Article 346. https://doi.org/10.1186/s12879-024-09210-6

Background: This study explores regional variations in COVID-19 hospitalization rates, in-hospital mortality, and acute kidney injury (AKI) in England. We investigated the influence of population demographic characteristics, viral strain changes, and... Read More about Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data.

Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service (2024)
Journal Article
Radford, S. J., Abdul-Aema, B., Tench, C., Leighton, P., Coad, J., & Moran, G. W. (2024). Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service. Scandinavian Journal of Gastroenterology, https://doi.org/10.1080/00365521.2024.2330588

Background: Imaging is used to monitor disease activity in small bowel Crohn’s disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, pati... Read More about Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study (2024)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C., Marciani, L., Spiller, R., Crooks, C., …Smyth, A. R. (2024). A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study. NIHR Open Research, 3, Article 65. https://doi.org/10.3310/nihropenres.13510.2

Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung funct... Read More about A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., …Abhishek, A. (in press). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, Article keae175. https://doi.org/10.1093/rheumatology/keae175

Objective To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s). Methods Adu... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF - A Systematic Review and Meta-Analysis (2024)
Journal Article
Alenezi, S. A., Khan, R., & Amer, S. (2024). The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF - A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 13(6), Article 1578. https://doi.org/10.3390/jcm13061578

(1) Background: Current evidence indicates that women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization (IVF) have an increased likelihood of adverse pregnancy outcomes. The objective of this systematic review was to clarify t... Read More about The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF - A Systematic Review and Meta-Analysis.