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Alignment of the Genomes of Brachypodium distachyon and Temperate Cereals and Grasses Using Bacterial Artificial Chromosome Landing With Fluorescence in Situ Hybridization (2006)
Journal Article
Hasterok, R., Marasek, A., Donnison, I. S., Armstead, I., Thomas, A., King, I. P., …Jenkins, G. (2006). Alignment of the Genomes of Brachypodium distachyon and Temperate Cereals and Grasses Using Bacterial Artificial Chromosome Landing With Fluorescence in Situ Hybridization. Genetics, 173(1), 349-362. https://doi.org/10.1534/genetics.105.049726

As part of an initiative to develop Brachypodium distachyon as a genomic “bridge” species between rice and the temperate cereals and grasses, a BAC library has been constructed for the two diploid (2n = 2x = 10) genotypes, ABR1 and ABR5. The library... Read More about Alignment of the Genomes of Brachypodium distachyon and Temperate Cereals and Grasses Using Bacterial Artificial Chromosome Landing With Fluorescence in Situ Hybridization.

The influence of the fitness evaluation method on the performance of multiobjective search algorithms (2006)
Journal Article
Burke, E. K., & Landa Silva, J. D. (2006). The influence of the fitness evaluation method on the performance of multiobjective search algorithms. European Journal of Operational Research, 169(3), 875-897. https://doi.org/10.1016/j.ejor.2004.08.028

In this paper we are concerned with finding the Pareto optimal front or a good approximation to it. Since non-dominated solutions represent the goal in multiobjective optimisation, the dominance relation is frequently used to establish preference bet... Read More about The influence of the fitness evaluation method on the performance of multiobjective search algorithms.

Inhibition of metal dusting of alloy 800H by laser surface melting (2006)
Journal Article
Voisey, K., Liu, Z., & Stott, F. (2006). Inhibition of metal dusting of alloy 800H by laser surface melting. Applied Surface Science, 252(10), https://doi.org/10.1016/j.apsusc.2005.05.040

Metal dusting is a catastrophic carburisation phenomenon that occurs at temperatures of 450-850°C in atmospheres of high carbon activity. The resistance of alloys to corrosion, including metal dusting, relies on the formation of a dense, adherent oxi... Read More about Inhibition of metal dusting of alloy 800H by laser surface melting.

Spatial fluctuations in the spectral shape of the UV background at 2 (2006)
Journal Article
S. Bolton, J., G. Haehnelt, M., Viel, M., & F. Carswell, R. (2006). Spatial fluctuations in the spectral shape of the UV background at 2. Monthly Notices of the Royal Astronomical Society, 366(4), 1378-1390. https://doi.org/10.1111/j.1365-2966.2006.09927.x

The low density hydrogen and helium in the IGM probed by QSO absorption lines is sensitive to the amplitude and spectral shape of the metagalactic UV background. We use realistic HI and HeII Ly-alpha forest spectra, constructed from state-of-the-art... Read More about Spatial fluctuations in the spectral shape of the UV background at 2.

Effects of fatty acids on skeletal muscle cell differentiation in vitro (2006)
Journal Article
Hurley, M. S., Flux, C., Salter, A. M., & Brameld, J. M. (2006). Effects of fatty acids on skeletal muscle cell differentiation in vitro. British Journal of Nutrition, 95(3), 623-630. https://doi.org/10.1079/BJN20051711

Previous studies have shown stimulatory effects of linoleic acid (LA, C18:2) on differentiation of rat muscle cells in culture (Allen et al. 1985), but there appears to be little investigation of the effects of other fatty acids. The present study th... Read More about Effects of fatty acids on skeletal muscle cell differentiation in vitro.

Does technological diversification promote innovation?: An empirical analysis for European firms (2006)
Journal Article
Garcia-Vega, M. (2006). Does technological diversification promote innovation?: An empirical analysis for European firms. Research Policy, 35(2), https://doi.org/10.1016/j.respol.2005.09.006

This paper analyses the impact of technological diversity on innovative activity at the firm level. The empirical study on a panel of European R&D active companies shows that both R&D intensity and patents increase with the degree of technological di... Read More about Does technological diversification promote innovation?: An empirical analysis for European firms.

Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy (2006)
Journal Article
Green, K. L., Southgate, T. D., Mulryan, K., Fairbairn, L. J., Stern, P. L., & Gaston, K. (2006). Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy. Human Gene Therapy, 17(2), 147-157. https://doi.org/10.1089/hum.2006.17.147

Human papillomaviruses (HPVs) are a causative agent of cervical cancer and are implicated in several other types of malignant disease including cancer of the vulva, oral cancer, and skin cancer. In HPV-transformed cells, expression of the viral E6 an... Read More about Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy.

Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain (2006)
Journal Article
Soufi, A., Smith, C., Clarke, A. R., Gaston, K., & Jayaraman, P. (2006). Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain. Journal of Molecular Biology, 358(4), 943-962. https://doi.org/10.1016/j.jmb.2006.02.020

Homeodomain proteins regulate multiple developmental pathways by altering gene expression temporally and in a tissue-specific fashion. The Proline Rich Homeodomain protein (PRH/Hex) is a transcription factor and an essential regulator of embryonic de... Read More about Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.

Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556] (2006)
Journal Article
Masud, T., Coupland, C., Drummond, A. E., Gladman, J. R., Kendrick, D., Sach, T., Harwood, R. H., Kumar, P., Morris, R., Taylor, R., Youde, J., & Conroy, S. (2006). Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556]. Trials, 7(1), Article 10. https://doi.org/10.1186/1745-6215-7-5

Falls in older people are a major public health concern in terms of morbidity, mortality and cost. Previous studies suggest that multifactorial interventions can reduce falls, and many geriatric day hospitals are now offering falls intervention progr... Read More about Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556].

Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33 (2006)
Journal Article
Tarr, A. W., Owsianka, A. M., Timms, J. M., McClure, C. P., Brown, R. J., Hickling, T. P., …Ball, J. K. (2006). Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33. Hepatology, 43(3), 592-601. https://doi.org/10.1002/hep.21088

The mouse monoclonal antibody (MAb) AP33, recognizing a 12 amino acid linear epitope in the hepatitis C virus (HCV) E2 glycoprotein, potently neutralizes retroviral pseudoparticles (HCVpp) carrying genetically diverse HCV envelope glycoproteins. Cons... Read More about Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33.

Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction (2006)
Journal Article
Soufi, A., Gaston, K., & Jayaraman, P. (2006). Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction. International Journal of Biological Macromolecules, 39(1-3), 45-50. https://doi.org/10.1016/j.ijbiomac.2006.01.004

The Proline-Rich Homeodomain (PRH) protein is a regulator of transcription and translation and plays a key role in the control of cell proliferation and cell differentiation. PRH contains an N-terminal proline-rich domain that can repress transcripti... Read More about Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction.

Multiple-retrieval case-based reasoning for course timetabling problems (2006)
Journal Article
Burke, E., MacCarthy, B. L., Petrovic, S., & Qu, R. (2006). Multiple-retrieval case-based reasoning for course timetabling problems. Journal of the Operational Research Society, 57(2),

The structured representation of cases by attribute graphs in a Case-Based Reasoning (CBR) system for course timetabling has been the subject of previous research by the authors. In that system, the case base is organised as a decision tree and the r... Read More about Multiple-retrieval case-based reasoning for course timetabling problems.

A small temperature rise may contribute towards the apparent induction by microwaves of heatshock gene expression in the nematode Caenorhabditis elegans (2006)
Journal Article
Dawe, A. S., Smith, B., Thomas, D. W., Greedy, S., Vasic, N., Gregory, A., …de Pomerai, D. I. (2006). A small temperature rise may contribute towards the apparent induction by microwaves of heatshock gene expression in the nematode Caenorhabditis elegans. Bioelectromagnetics, 27(2), https://doi.org/10.1002/bem.20192

We have previously reported that low-intensity microwave exposure (0.75-1.0 GHz CW at 0.5 W; SAR 4-40 mW kg-1) can induce an apparently non-thermal heat-shock response in Caenorhabditis elegans worms carrying hsp16-1::reporter genes. Using matched co... Read More about A small temperature rise may contribute towards the apparent induction by microwaves of heatshock gene expression in the nematode Caenorhabditis elegans.

A classification of tasks for the systematic study of immune response using functional genomics data (2006)
Journal Article
Hedeler, C., Paton, N., Behnke, J. M., Bradley, J. E., Hamshere, M., & Else, K. (2006). A classification of tasks for the systematic study of immune response using functional genomics data. Parasitology, 132(2), https://doi.org/10.1017/S0031182005008796

A full understanding of the immune system and its responses to infection by different pathogens is important for the
development of anti-parasitic vaccines. A growing number of large-scale experimental techniques, such as microarrays, are being used... Read More about A classification of tasks for the systematic study of immune response using functional genomics data.

Effort-reward imbalance at work and the co-occurrence of lifestyle risk factors: cross-sectional survey in a sample of 36,127 public sector employees (2006)
Journal Article
Kouvonen, A., Kivimäki, M., Virtanen, M., Heponiemi, T., Elovainio, M., Pentti, J., …Vahtera, J. (2006). Effort-reward imbalance at work and the co-occurrence of lifestyle risk factors: cross-sectional survey in a sample of 36,127 public sector employees. BMC Public Health, 6,

Background
In occupational life, a mismatch between high expenditure of effort and receiving few rewards may promote the co-occurrence of lifestyle risk factors, however, there is insufficient evidence to support or refute this hypothesis. The aim o... Read More about Effort-reward imbalance at work and the co-occurrence of lifestyle risk factors: cross-sectional survey in a sample of 36,127 public sector employees.

Seismic retrofit schemes for RC structures and local-global consequences (2006)
Journal Article
Thermou, G., & Elnashai, A. (2006). Seismic retrofit schemes for RC structures and local-global consequences. Progress in Structural Engineering and Materials, 8(1), 1-15. https://doi.org/10.1002/pse.208

A review of repair schemes for reinforced concrete frame buildings is presented in this paper, within the context of global objectives of the intervention process. Local as well as global intervention measures are discussed and their technological ap... Read More about Seismic retrofit schemes for RC structures and local-global consequences.

Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension (2006)
Journal Article
Machado, R. D., Aldred, M. A., James, V., Harrison, R. E., Patel, B., Schwalbe, E. C., …Trembath, R. C. (2006). Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension. Human Mutation, 27(2), 121-132. https://doi.org/10.1002/humu.20285

Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder is typically sporadic, and in such cases the term idiopathic PAH... Read More about Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension.