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A classification of tasks for the systematic study of immune response using functional genomics data

Hedeler, C.; Paton, N.W.; Behnke, Jerzy M.; Bradley, Janette E.; Hamshere, M.G.; Else, K.J.

Authors

C. Hedeler

N.W. Paton

Jerzy M. Behnke

Janette E. Bradley

M.G. Hamshere

K.J. Else



Abstract

A full understanding of the immune system and its responses to infection by different pathogens is important for the
development of anti-parasitic vaccines. A growing number of large-scale experimental techniques, such as microarrays, are being used to gain a better understanding of the immune system. To analyse the data generated by these experiments,
methods such as clustering are widely used. However, individual applications of these methods tend to analyse the
experimental data without taking publicly available biological and immunological knowledge into account systematically and in an unbiased manner. To make best use of the experimental investment, to benefit from existing evidence, and to support the findings in the experimental data, available biological information should be included in the analysis in a systematic manner. In this review we present a classification of tasks that shows how experimental data produced by studies of the immune system can be placed in a broader biological context. Taking into account available evidence, the classification can be used to identify different ways of analysing the experimental data systematically. We have used the classification to identify alternative ways of analysing microarray data, and illustrate its application using studies of immune responses in mice to infection with the intestinal nematode parasites Trichuris muris and Heligmosomoides polygyrus.

Journal Article Type Article
Publication Date Feb 1, 2006
Journal Parasitology
Print ISSN 0031-1820
Electronic ISSN 0031-1820
Publisher Cambridge University Press (CUP)
Peer Reviewed Peer Reviewed
Volume 132
Issue 2
APA6 Citation Hedeler, C., Paton, N., Behnke, J. M., Bradley, J. E., Hamshere, M., & Else, K. (2006). A classification of tasks for the systematic study of immune response using functional genomics data. Parasitology, 132(2), doi:10.1017/S0031182005008796
DOI https://doi.org/10.1017/S0031182005008796
Keywords Classification, Systematic Immunological Bioinformatics, Intestinal Nematode
Publisher URL http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=405519&fileId=S0031182005008796
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information Copyright Cambridge University Press

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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