Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation

Vassey, Matthew J.; Figueredo, Grazziela P.; Scurr, David J.; Vasilevich, Aliaksei S.; Vermeulen, Steven; Carlier, Aur�lie; Luckett, Jeni; Beijer, Nick R.M.; Williams, Paul; Winkler, David A.; de Boer, Jan; Ghaemmaghami, Amir M.; Alexander, Morgan R.

doi:10.1002/advs.201903392

All Outputs (5)

Translational pharmacology of an inhaled small molecule ?v?6 integrin inhibitor for idiopathic pulmonary fibrosis (2020)
Journal Article
John, A. E., Graves, R. H., Pun, K. T., Vitulli, G., Forty, E. J., Mercer, P. F., …Slack, R. J. (2020). Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis. Nature Communications, 11(1), Article 4659. https://doi.org/10.1038/s41467-020-18397-6

Discovery of hemocompatible bacterial biofilm-resistant copolymers (2020)
Journal Article
Singh, T., Hook, A. L., Luckett, J., Maitz, M. F., Sperling, C., Werner, C., …Alexander, M. R. (2020). Discovery of hemocompatible bacterial biofilm-resistant copolymers. Biomaterials, 260, Article 120312. https://doi.org/10.1016/j.biomaterials.2020.120312

© 2020 The Authors Blood-contacting medical devices play an important role within healthcare and are required to be biocompatible, hemocompatible and resistant to microbial colonization. Here we describe a high throughput screen for copolymers with t... Read More about Discovery of hemocompatible bacterial biofilm-resistant copolymers.

Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus (2020)
Journal Article
Blower, I., Tong, C., Sun, X., Murray, E., Luckett, J., Chan, W., …Hill, P. (2020). Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus. Sensors, 20(15), 1-12. https://doi.org/10.3390/s20154305

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Gaussia luciferase (GLuc) is a secreted protein with significant potential for use as a reporter of gene expression in bacterial pathogenicity studies. To date there are relatively few example... Read More about Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus.

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo (2020)
Journal Article
Rostam, H. M., Fisher, L. E., Hook, A. L., Burroughs, L., Luckett, J. C., Figueredo, G. P., …Ghaemmaghami, A. M. (2020). Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo. Matter, 2(6), 1564-1581. https://doi.org/10.1016/j.matt.2020.03.018

© 2020 The Author(s) Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive pro... Read More about Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo.

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation (2020)
Journal Article
Vassey, M. J., Figueredo, G. P., Scurr, D. J., Vasilevich, A. S., Vermeulen, S., Carlier, A., …Alexander, M. R. (2020). Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation. Advanced Science, 7(11), https://doi.org/10.1002/advs.201903392

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Macrophages play a central role in orchestrating immune responses to foreign materials, which are often responsible for the failure of implanted medical devices. Material t... Read More about Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation.