An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress

Feneberg, Emily; Gordon, David; Thompson, Alexander G.; Finelli, Mattéa J.; Dafinca, Ruxandra; Candalija, Ana; Charles, Philip D.; Mäger, Imre; Wood, Matthew J.; Fischer, Roman; Kessler, Benedikt M.; Gray, Elizabeth; Turner, Martin R.; Talbot, Kevin

doi:10.1016/j.nbd.2020.105050

All Outputs (3)

The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour (2020)
Journal Article
Castroflorio, E., den Hoed, J., Svistunova, D., Finelli, M. J., Cebrian-Serrano, A., Corrochano, S., …Oliver, P. L. (2021). The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour. Cellular and Molecular Life Sciences, 78(7), 3503-3524. https://doi.org/10.1007/s00018-020-03721-6

Members of the Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic (TLDc) protein family are associated with multiple neurodevelopmental disorders, although their exact roles in disease remain unclear. For example, nuclear receptor coactivato... Read More about The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour.

Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation (2020)
Journal Article
Finelli, M. J. (2020). Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation. Frontiers in Aging Neuroscience, 12, Article 254. https://doi.org/10.3389/fnagi.2020.00254

Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of pro... Read More about Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation.

An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress (2020)
Journal Article
Feneberg, E., Gordon, D., Thompson, A. G., Finelli, M. J., Dafinca, R., Candalija, A., …Talbot, K. (2020). An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress. Neurobiology of Disease, 144, Article 105050. https://doi.org/10.1016/j.nbd.2020.105050

TDP-43 pathology is a key feature of amyotrophic lateral sclerosis (ALS), but the mechanisms linking TDP-43 to altered cellular function and neurodegeneration remain unclear. We have recently described a mouse model in which human wild-type or mutant... Read More about An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.