Dr MATTEA FINELLI MATTEA.FINELLI@NOTTINGHAM.AC.UK
ASSISTANT PROFESSOR
Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation
Finelli, Matt�a J.
Authors
Contributors
Dr MATTEA FINELLI MATTEA.FINELLI@NOTTINGHAM.AC.UK
Project Leader
Abstract
Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular physiology and coordinately regulates the function of redox-sensitive proteins. It plays a particularly important role in the brain, which is a major producer of RONS. Aberrant redox PTMs of protein thiols can impair protein function and are associated with several diseases. This mini review article aims to evaluate the role of redox PTMs of protein thiols, in particular S-nitrosation, in brain aging, and in neurodegenerative diseases. It also discusses the potential of using redox-based therapeutic approaches for neurodegenerative conditions.
Citation
Finelli, M. J. (2020). Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation. Frontiers in Aging Neuroscience, 12, Article 254. https://doi.org/10.3389/fnagi.2020.00254
| Journal Article Type | Review |
|---|---|
| Acceptance Date | Jul 24, 2020 |
| Online Publication Date | Sep 3, 2020 |
| Publication Date | 2020-09 |
| Deposit Date | Sep 14, 2020 |
| Publicly Available Date | Sep 14, 2020 |
| Journal | Frontiers in Aging Neuroscience |
| Publisher | Frontiers Media |
| Peer Reviewed | Peer Reviewed |
| Volume | 12 |
| Article Number | 254 |
| DOI | https://doi.org/10.3389/fnagi.2020.00254 |
| Keywords | Ageing; Cognitive Neuroscience |
| Public URL | https://nottingham-repository.worktribe.com/output/4887891 |
| Publisher URL | https://www.frontiersin.org/articles/10.3389/fnagi.2020.00254/full |
Files
fnagi-12-00254
(2.4 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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