Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge

Clementi, Nicola; Criscuolo, Elena; Cappelletti, Francesca; Quaranta, Paola; Pistello, Mauro; Diotti, Roberta A.; Sautto, Giuseppe A.; Tarr, Alexander W.; Mailland, Federico; Concas, Daniela; Burioni, Roberto; Clementi, Massimo; Mancini, Nicasio

doi:10.1016/j.antiviral.2017.03.028

All Outputs (2)

How have retrovirus pseudotypes contributed to our understanding of viral entry? (2017)
Journal Article
Tarr, A. W., & King, B. (2017). How have retrovirus pseudotypes contributed to our understanding of viral entry?. Future Virology, 12(10), Article 0062. https://doi.org/10.2217/fvl-2017-0062

Study of virus entry into host cells is important for understanding viral tropism and pathogenesis. Studying the entry of in vitro cultured viruses is not always practicable. Study of highly pathogenic viruses, viruses that do not grow in culture, an... Read More about How have retrovirus pseudotypes contributed to our understanding of viral entry?.

Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge (2017)
Journal Article
Clementi, N., Criscuolo, E., Cappelletti, F., Quaranta, P., Pistello, M., Diotti, R. A., …Mancini, N. (2017). Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge. Antiviral Research, 143, https://doi.org/10.1016/j.antiviral.2017.03.028

The present study focused on inhibition of HSV-1 and -2 replication and pathogenesis in vitro and in vivo, through the selective targeting of the envelope glycoprotein D. Firstly, a human monoclonal antibody (Hu-mAb#33) was identified that could neut... Read More about Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge.