How have retrovirus pseudotypes contributed to our understanding of viral entry?

Tarr, Alexander W.; King, Barnabas

Abstract

Study of virus entry into host cells is important for understanding viral tropism and pathogenesis. Studying the entry of in vitro cultured viruses is not always practicable. Study of highly pathogenic viruses, viruses that do not grow in culture, and viruses that rapidly change phenotype in vitro can all benefit from alternative models of entry. Retrovirus particles can be engineered to display the envelope proteins of heterologous enveloped viruses. This approach, broadly termed ‘pseudotyping’, is an important technique for interrogating virus entry. In this perspective we consider how retrovirus pseudotypes have addressed these challenges and improved our understanding of the entry pathways of diverse virus species, including Ebolavirus, human immunodeficiency virus and hepatitis C virus.

Citation

Tarr, A. W., & King, B. (2017). How have retrovirus pseudotypes contributed to our understanding of viral entry?. Future Virology, 12(10), Article 0062. https://doi.org/10.2217/fvl-2017-0062

• Journal Article Type: Article
• Acceptance Date: Jul 17, 2017
• Online Publication Date: Sep 29, 2017
• Publication Date: Oct 31, 2017
• Deposit Date: Oct 3, 2017
• Publicly Available Date: Sep 30, 2018
• Journal: Future Virology
• Print ISSN: 1746-0794
• Electronic ISSN: 1746-0808
• Publisher: Future Medicine
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 10
• Article Number: 0062
• DOI: https://doi.org/10.2217/fvl-2017-0062
• Keywords: Pseudotype, Pseudoparticle, Entry pathway
• Public URL: https://nottingham-repository.worktribe.com/output/873000
• Publisher URL: https://www.futuremedicine.com/doi/10.2217/fvl-2017-0062