All Outputs (594)

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species (2012)
Journal Article

Oxidative stress mediated by reactive oxygen species (ROS) is linked to degenerative conditions in humans and damage to an array of cellular components. However, it is unclear which molecular target(s) may be the primary “Achilles’ heel” of organisms... Read More about The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species.

The impact of individual budgets on the targeting of support: Findings from a national evaluation of pilot projects in England (2012)
Journal Article

Individual or personal budgets are part of a growing international trend to encourage greater choice and control over social care services at a time of financial austerity. The authors' evaluation of individual budgets found that levels of allocated... Read More about The impact of individual budgets on the targeting of support: Findings from a national evaluation of pilot projects in England.

The linear spin-up of a stratified, rotating fluid in a square cylinder (2012)
Journal Article

Here we present experimental and theoretical results for how a stratified fluid, initially rotating as a solid body with constant angular velocity, , within a closed cylinder of square cross-section, is spun up when subject to a small, impulsive incr... Read More about The linear spin-up of a stratified, rotating fluid in a square cylinder.

Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census (2012)
Journal Article

Background The population of dogs and cats passing through rescue shelters may be subject to compromised welfare and increased susceptibility to disease. Little information exists to describe this population, its dynamics and associated management... Read More about Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census.

Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol (2012)
Journal Article

Introduction Early intervention for childhood behavioural problems may help improve health and educational outcomes in affected children and reduce the likelihood of developing additional difficulties. The National Institute for Health and Clinical... Read More about Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol.

Identity and public realm (2012)
Journal Article

In a very general sense, Identities materialise space to create significance, meaning and spatial relations. In urban design terms, identity is considered to be a fixed point of thought and being or ground of actions. However, as Hall (1989) describe... Read More about Identity and public realm.

A flaw in Kripke's modal argument? (2012)
Journal Article

Efficient online subspace learning with an indefinite kernel for visual tracking and recognition (2012)
Journal Article

We propose an exact framework for online learning with a family of indefinite (not positive) kernels. As we study the case of nonpositive kernels, we first show how to extend kernel principal component analysis (KPCA) from a reproducing kernel Hilber... Read More about Efficient online subspace learning with an indefinite kernel for visual tracking and recognition.

Calpain system protein expression in basal-like and triple-negative invasive breast cancer (2012)
Journal Article

Background: Basal-like and triple-negative breast tumours encompass an important clinical subgroup and biomarkers that can prognostically stratify these patients are required. Materials and methods: We investigated two breast cancer tissue microarr... Read More about Calpain system protein expression in basal-like and triple-negative invasive breast cancer.

Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity (2012)
Journal Article

The present study aimed to investigate the actions of fibroblast growth factor 21 (FGF21) on energy balance in a natural model of relative fatness, the Siberian hamster. Hamsters were studied under long days (LD) to promote weight gain, or short days... Read More about Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity.

Sliding mode contouring control design using nonlinear sliding surface for three-dimensional machining (2012)
Journal Article

Machining accuracy as well as consumed energy saving are important issues in machining by multi-axis feed drive systems. The contour error, which is defined as the error component orthogonal to the desired contour curve, is a good indicator of machin... Read More about Sliding mode contouring control design using nonlinear sliding surface for three-dimensional machining.

Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study (2012)
Journal Article

Background Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung funct... Read More about Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study.

The covariance of multi-field perturbations, pseudo-susy and fNL (2012)
Journal Article

We reconsider cosmological perturbation theory for multi-component scalars, enforcing covariance in field-space, and ensuring that phyical observations are independent of field re-definitions. We use the formalism to clarify some issues in the litera... Read More about The covariance of multi-field perturbations, pseudo-susy and fNL.

Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops (2012)
Journal Article

Background With increased governmental interest in value assessment of technologies and where medical device manufacturers are finding it increasingly necessary to become more familiar with economic evaluation methods, the study sought to explore... Read More about Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops.

Health in the NHS: lifestyle behaviours of hospital employees (2012)
Journal Article

Kin selection, quorum sensing and virulence in pathogenic bacteria (2012)
Journal Article

Bacterial growth and virulence often depends upon the cooperative release of extracellular factors excreted in response to quorum sensing (QS).We carried out an in vivo selection experiment in mice to examine how QS evolves in response to variation... Read More about Kin selection, quorum sensing and virulence in pathogenic bacteria.

Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates (2012)
Journal Article

The physiological oxygen concentration of many tissues is far lower than that in which cells are typically cultured in vitro and this may inadvertently influence the proliferation and differentiation potential of many cell types. Muscle derived stem... Read More about Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates.

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release (2012)
Journal Article

Respiratory epithelial cells and macrophages are the key innate immune cells that play an important role in the pathogenesis of influenza A virus infection. We found that these two cell types from both human and pig showed comparable susceptibilities... Read More about Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release.

'The life of individuals as well as of nations': international law and the League of Nations' anti-trafficking governmentalities (2012)
Journal Article

This paper will address an often-neglected agenda of the much-derided League of Nations: its ‘social’ and ‘technical’ works. These targeted human security through regulating different forms of international mobility, including the fight against traff... Read More about 'The life of individuals as well as of nations': international law and the League of Nations' anti-trafficking governmentalities.

Thin slice sampling of video footage for mother/child interaction: application to single cases (2012)
Journal Article

The purpose was to test the reliability of short samples of parent/child interaction for use in single-subject research. Four variable pairs of mother/child behaviour were coded for seven mother/child play sessions. Each session lasted 20 min and 18... Read More about Thin slice sampling of video footage for mother/child interaction: application to single cases.