All Outputs (404)

The special systems biology of the sperm (2011)
Journal Article

Spermatozoa represent a highly specialized cell type, with a minimalist structure designed to fulfil a single principal function: the transport of an intact single-copy haploid genome to the site of fertilization in the oviduct, and consequent zygote... Read More about The special systems biology of the sperm.

The role of oxidative stress and antioxidant supplementation in pregnancy disorders (2011)
Journal Article

Oxidative stress is widely implicated in failed reproductive performance including infertility, miscarriage, diabetes-related congenital malformations and preeclampsia. Maternal obesity is a strong risk factor for preeclampsia, and recently, in an an... Read More about The role of oxidative stress and antioxidant supplementation in pregnancy disorders.

Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry (2011)
Journal Article

Uniform cellular distribution is a prerequisite to forming tissue within porous scaffolds, but the seeding process often results in preferential adhesion of cells at the periphery. We develop a vapour phase coating strategy which is readily applicabl... Read More about Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry.

An interpretative phenomenological analysis of posttraumatic growth in adults bereaved by suicide (2011)
Journal Article

This study explored experiences of posttraumatic growth in adults bereaved by suicide. Six participants were interviewed using a semi-structured interview schedule. Transcribed interviews were analyzed from an interpretative phenomenological framewor... Read More about An interpretative phenomenological analysis of posttraumatic growth in adults bereaved by suicide.

The pragmatic face of the covert idealist: the role of Allen Dulles in US policy discussions on Latin America, 1953–61 (2011)
Journal Article

Assessments of the CIA’s role in Latin America during the 1950s have tended to focus predominantly on the twin case-studies of Guatemala and Cuba. Consequently, the Agency’s role – and, more broadly, that of its head Allen Dulles – has come to be see... Read More about The pragmatic face of the covert idealist: the role of Allen Dulles in US policy discussions on Latin America, 1953–61.

Facing the Future? David Owen and Social Democracy in the 1980s and Beyond (2011)
Journal Article

David Owen entered the House of Commons as member for Plymouth in 1966. He became a junior minister under Harold Wilson by 1968 and quickly established himself as a leading figure of the Labour right. From 1977 to 1979 he was Britain's youngest post-... Read More about Facing the Future? David Owen and Social Democracy in the 1980s and Beyond.

Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner (2011)
Journal Article

NS5A plays a critical, yet poorly defined, role in hepatitis C virus genome replication. The protein consists of three domains, each of which is able to bind independently to the 3? untranslated region (UTR) of the viral positive strand genomic RNA.... Read More about Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner.

INSL3 in the ruminant: A powerful indicator of gender- and genetic-specific feto-maternal dialogue (2011)
Journal Article

The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells from both fetal and adult testes. Consequently, it is a major gender-specific circulating hormone in the male fetus, where it is responsible for the first pha... Read More about INSL3 in the ruminant: A powerful indicator of gender- and genetic-specific feto-maternal dialogue.

Chapter 1 - The structure of the adenosine receptors implications for drug discovery (2011)
Journal Article

Extracellular adenosine mediates most of its physiological effects via an interaction with four G protein-coupled receptors (GPCRs), the adenosine receptors (ARs). These ARs are important pharmacological targets in the treatment of a wide variety of... Read More about Chapter 1 - The structure of the adenosine receptors implications for drug discovery.

Going paperless at the emergency department: A socio-technical study of an information system for patient tracking (2011)
Journal Article

Purpose: The purpose of this study was to examine nurses' attitudes and reflection on the transformation of their workpractices after the implementation of an Emergency Department Information System (EDIS). Methods: A qualitative study using intervie... Read More about Going paperless at the emergency department: A socio-technical study of an information system for patient tracking.

Nonsmooth dynamics in spiking neuron models (2011)
Journal Article

Large scale studies of spiking neural networks are a key part of modern approaches to understanding the dynamics of biological neural tissue. One approach in computational neuroscience has been to consider the detailed electrophysiological propertie... Read More about Nonsmooth dynamics in spiking neuron models.

H-NS mediates the dissociation of a refractory protein–DNA complex during Tn10/IS10 transposition (2011)
Journal Article

Tn10/IS10 transposition takes place in the context of a protein–DNA complex called a transpososome. During the reaction, the transpososome undergoes several conformational changes. The host proteins IHF and H-NS, which also are global regulators of g... Read More about H-NS mediates the dissociation of a refractory protein–DNA complex during Tn10/IS10 transposition.

Visual motion induces a forward prediction of spatial pattern (2011)
Journal Article

Cortical motion analysis continuously encodes image velocity but might also be used to predict future patterns of sensory input along the motion path. We asked whether this predictive aspect of motion is exploited by the human visual system. Targets... Read More about Visual motion induces a forward prediction of spatial pattern.

Effect of questionnaire length, personalisation and reminder type on response rate to a complex postal survey: Randomised controlled trial (2011)
Journal Article

Background Minimising participant non-response in postal surveys helps to maximise the generalisability of the inferences made from the data collected. The aim of this study was to examine the effect of questionnaire length, personalisation and remi... Read More about Effect of questionnaire length, personalisation and reminder type on response rate to a complex postal survey: Randomised controlled trial.

Bamgro: A simple model to simulate the response of bambara groundnut to abiotic stress (2011)
Journal Article

Simulation models for many crops are often simple, empirical equations that lack generality across different locations or different levels of abiotic stress making them difficult to apply by independent researchers. The objective of this paper is to... Read More about Bamgro: A simple model to simulate the response of bambara groundnut to abiotic stress.

Reconciliation of Local and Global Symmetries for a Class of Crystals with Defects (2011)
Journal Article

We consider the symmetry of discrete and continuous crystal structures which are compatible with a given choice of dislocation density tensor. By introducing the notion of a 'defective point group' (determined by the dislocation density tensor), we g... Read More about Reconciliation of Local and Global Symmetries for a Class of Crystals with Defects.

Calpastatin is associated with lymphovascular invasion in breast cancer (2011)
Journal Article

Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to e... Read More about Calpastatin is associated with lymphovascular invasion in breast cancer.

The interactions of CO2, ethanol, hop acids and sweetener on flavour perception in a model beer (2011)
Journal Article

Beer is a complex beverage. Beer flavour is a multisensory experience in which, in addition to aroma volatiles, CO2, ethanol, bitterness (hop acids) and sweetness all contribute. To investigate the interactions between these fundamental components, a... Read More about The interactions of CO2, ethanol, hop acids and sweetener on flavour perception in a model beer.

Novel approaches to assessing cardiac safety - Proceedings of a workshop: Regulators, industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs (2011)
Journal Article

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. I. Regulation of myogenesis and environmental impact (2011)
Journal Article

Skeletal muscle development in vertebrates - also termed myogenesis - is a highly integrated process. Evidence to date indicates that the processes are very similar across mammals, poultry and fish, although the timings of the various steps differ co... Read More about Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. I. Regulation of myogenesis and environmental impact.