All Outputs (573)

The role of hepatic lipid composition in obesity-related metabolic disease (2021)
Journal Article
Willis, S. A., Bawden, S., Malaikah, S., Sargeant, J. A., Stensel, D. J., Aithal, G. P., & King, J. A. (2021). The role of hepatic lipid composition in obesity-related metabolic disease. Liver International, 41(12), 2819-2835. https://doi.org/10.1111/liv.15059

Obesity is a primary antecedent to non-alcoholic fatty liver disease whose cardinal feature is excessive hepatic lipid accumulation. Although total hepatic lipid content closely associates with hepatic and systemic metabolic dysfunction, accumulating... Read More about The role of hepatic lipid composition in obesity-related metabolic disease.

Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging (2021)
Journal Article
O’Farrell, C., Hoad, C. L., Stamatopoulos, K., Marciani, L., Sulaiman, S., Simmons, M. J. H., & Batchelor, H. K. (2021). Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging. Pharmaceutics, 13(10), Article 1545. https://doi.org/10.3390/pharmaceutics13101545

Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us... Read More about Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging.

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle (2021)
Journal Article
Chidambaram, S. B., Essa, M. M., Rathipriya, A., Bishir, M., Ray, B., Mahalakshmi, A. M., …Monaghan, T. M. (2022). Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle. Pharmacology and Therapeutics, 231, Article 107988. https://doi.org/10.1016/j.pharmthera.2021.107988

The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent observations suggest a bidirectional communication between the gut micr... Read More about Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle.

Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity (2021)
Journal Article
Innes, H., Crooks, C. J., Aspinall, E., Card, T. R., Hamill, V., Dillon, J., …Morling, J. R. (2022). Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity. Hepatology, 75(2), 369-378. https://doi.org/10.1002/hep.32123

Background and Aims: It is thought that alcohol intake and body mass index (BMI) interact supra-additively to modulate the risk of cirrhosis, but evidence for this phenomenon is limited. We investigated the interrelationship between alcohol and BMI o... Read More about Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity.

Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients (2021)
Journal Article
Jewell, A., Williams, H., Hoad, C. L., Gellert, P. R., Ashford, M. B., Butler, J., …Gershkovich, P. (2021). Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients. Pharmaceutics, 13(9), Article 1343. https://doi.org/10.3390/pharmaceutics13091343

Dietary lipids and some pharmaceutical lipid excipients can facilitate the targeted delivery of drugs to the intestinal lymphatics. Here, the feasibility of magnetic resonance imaging (MRI) for imaging lipid uptake into the intestinal lymphatics was... Read More about Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients.

The Effect of Covid-19 on Alcohol Use Disorder and the Role of Universal Alcohol Screening in an Inpatient Setting: A Retrospective Cohort Control Study (2021)
Journal Article
Subhani, M., Sheth, A., Unitt, S., Aithal, G. P., Ryder, S. D., & Morling, J. R. (2022). The Effect of Covid-19 on Alcohol Use Disorder and the Role of Universal Alcohol Screening in an Inpatient Setting: A Retrospective Cohort Control Study. Alcohol and Alcoholism, 57(2), 203-210. https://doi.org/10.1093/alcalc/agab059

Aim: To assess the impact of Covid-19 on alcohol use disorders (AUD) and the role of universal alcohol screening (UAS) in an inpatient setting. Methods: Retrospective cohorts were defined as pre-pandemic and pandemic admitted to Nottingham University... Read More about The Effect of Covid-19 on Alcohol Use Disorder and the Role of Universal Alcohol Screening in an Inpatient Setting: A Retrospective Cohort Control Study.

Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain (2021)
Journal Article
Psaltis, E., Zaitoun, A. M., Neal, K. R., & Lobo, D. N. (2021). Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain. World Journal of Surgery, 45(12), 3592-3602. https://doi.org/10.1007/s00268-021-06288-w

Background Histologically normal appendices resected for right iliac fossa pain in children demonstrate immunohistochemical markers of inflammation. We aimed to establish if subclinical inflammation was present in histologically normal appendices re... Read More about Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain.

A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data (2021)
Journal Article
Bishton, M. J., Stilwell, P., Card, T. R., Lanyon, P., Ban, L., Elliss-Brookes, L., …Bythell, M. (2021). A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data. British Journal of Haematology, 194(6), 1039-1044. https://doi.org/10.1111/bjh.17768

We assessed the validity of coded healthcare data to identify cases of haemophagocytic lymphohistiocytosis (HLH). Hospital Episode Statistics (HES) identified 127 cases within five hospital Trusts 2013–2018 using ICD-10 codes D76.1, D76.2 and D76.3.... Read More about A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data.

Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020 (2021)
Journal Article
Seehra, J. K., Lewis-Lloyd, C., Koh, A., Theophilidou, E., Daliya, P., Adiamah, A., & Lobo, D. N. (2021). Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020. World Journal of Surgery, 45(11), 3266-3277. https://doi.org/10.1007/s00268-021-06268-0

Background: Presentation at academic conferences is an important marker of research productivity. However, not all accepted abstracts progress to full publication, and there is anecdotal evidence suggesting an imbalance in sex and ethnicity amongst p... Read More about Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020.

Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies (2021)
Journal Article
Gunn, D., Abbas, Z., Harris, H., Major, G., Hoad, C., Gowland, P., …Spiller, R. (2022). Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies. Gut, 71(5), 919-927. https://doi.org/10.1136/gutjnl-2021-324784

Objective: Health promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), limiting their intake. Our aim was to test if co-administering psyllium with inulin would reduce gas... Read More about Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies.

Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection (2021)
Journal Article
Urbanowicz, R. A., Tsoleridis, T., Jackson, H. J., Cusin, L., Duncan, J. D., Chappell, J. G., …Ollivere, B. J. (2021). Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection. Science Translational Medicine, 13(609), Article eabj0847. https://doi.org/10.1126/scitranslmed.abj0847

Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necess... Read More about Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection.

Perioperative Opioids - Reclaiming Lost Ground (2021)
Journal Article
Fawcett, W. J., Ljungqvist, O., & Lobo, D. N. (2021). Perioperative Opioids - Reclaiming Lost Ground. JAMA Surgery, 156(11), 997-998. https://doi.org/10.1001/jamasurg.2021.2858

Opium (poppy tears) has been in use since 3400 BCE, with historical writings recording its sedative, euphoric, and analgesic properties, but it was not until the 19th century that morphine was isolated, paving the way for its therapeutic use. The 20t... Read More about Perioperative Opioids - Reclaiming Lost Ground.

Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites (2021)
Journal Article
Vijay, A., Astbury, S., Panayiotis, L., Marques, F., Spector, T. D., Menni, C., & Valdes, A. M. (2021). Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites. Frontiers in Cardiovascular Medicine, 8, Article 691564. https://doi.org/10.3389/fcvm.2021.691564

Aims: The current study investigates the role of diet in mediating the gut microbiome-cardiovascular association which has not yet been explored in humans. Methods and results: Using a two-arm dietary intervention study in healthy participants (N=7... Read More about Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites.

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India (2021)
Journal Article
Monaghan, T. M., Biswas, R. N., Nashine, R. R., Joshi, S. S., Mullish, B. H., Seekatz, A. M., …Kashyap, R. S. (2021). Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India. Microorganisms, 9(7), Article 1485. https://doi.org/10.3390/microorganisms9071485

Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consu... Read More about Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India.

Socioeconomic inequalities in the incidence of alcohol-related liver disease: A nationwide Danish study (2021)
Journal Article
Askgaard, G., Fleming, K. M., Crooks, C., Kraglund, F., Jensen, C. B., West, J., & Jepsen, P. (2021). Socioeconomic inequalities in the incidence of alcohol-related liver disease: A nationwide Danish study. Lancet Regional Health – Europe, 8, 1-9. https://doi.org/10.1016/j.lanepe.2021.100172

Background: There is socio-economic inequality in total alcohol-related harm, but knowledge of inequality in the incidence of specific alcohol-related diseases would be beneficial for prevention. Registry-based studies with nationwide coverage may re... Read More about Socioeconomic inequalities in the incidence of alcohol-related liver disease: A nationwide Danish study.

Estimating the clinical prevalence of Wilson’s disease in the UK (2021)
Journal Article
Wijayasiri, P., Hayre, J., Nicholson, E. S., Kaye, P., Wilkes, E. A., Evans, J., …Aravinthan, A. D. (2021). Estimating the clinical prevalence of Wilson’s disease in the UK. JHEP Reports, 3(5), Article 100329. https://doi.org/10.1016/j.jhepr.2021.100329

Background and Aim The clinical prevalence of Wilson’s disease (WD) in the UK remains unknown. The estimated genetic prevalence in the UK, 142/million, is higher than the clinical prevalence (15/million) reported in other European studies. The aim o... Read More about Estimating the clinical prevalence of Wilson’s disease in the UK.

Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies (2021)
Journal Article
McGing, J. J., Radford, S. J., Francis, S. T., Serres, S., Greenhaff, P. L., & Moran, G. W. (2021). Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies. Alimentary Pharmacology and Therapeutics, 54(4), 368-387. https://doi.org/10.1111/apt.16465

Background: Fatigue is the inability to achieve or maintain an expected work output resulting from central or peripheral mechanisms. The prevalence of inflammatory bowel disease (IBD) fatigue can reach 86% in active disease, persisting in 50%-52% of... Read More about Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies.

Effect of intake of food hydrocolloids of bacterial origin on the glycemic response in humans: Systematic review and narrative synthesis (2021)
Journal Article
Alshammari, N. A., Taylor, M. A., Stevenson, R., Gouseti, O., Alyami, J., Muttakin, S., …Marciani, L. (2021). Effect of intake of food hydrocolloids of bacterial origin on the glycemic response in humans: Systematic review and narrative synthesis. Nutrients, 13(7), Article 2407. https://doi.org/10.3390/nu13072407

Diabetes mellitus is a chronic condition characterized by increased blood glucose levels from dysfunctional carbohydrate metabolism. Dietary intervention can help to prevent and manage the disease. Food hydrocolloids have been shown to have favorable... Read More about Effect of intake of food hydrocolloids of bacterial origin on the glycemic response in humans: Systematic review and narrative synthesis.

The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome (2021)
Journal Article
Mohr, S., Fritz, N., Hammer, C., Martínez, C., Berens, S., Schmitteckert, S., …Niesler, B. (2021). The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome. Journal of Cellular and Molecular Medicine, 25(16), 8047-8061. https://doi.org/10.1111/jcmm.16736

Irritable bowel syndrome (IBS) is a gut-brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying genetic mechanism... Read More about The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome.

Advanced preclinical models for evaluation of drug induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [Pro-Euro-DILI-Net] (2021)
Journal Article
Fernandez-Checa, J. C., Bagnaninchi, P., Ye, H., Sancho-Bru, P., Falcon-Perez, J. M., Royo, F., …Nelson, L. J. (2021). Advanced preclinical models for evaluation of drug induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [Pro-Euro-DILI-Net]. Journal of Hepatology, 75(4), 935-959. https://doi.org/10.1016/j.jhep.2021.06.021

Drug induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies. Given the wide use of both prescribed and over the counter drugs, DILI has become a majo... Read More about Advanced preclinical models for evaluation of drug induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [Pro-Euro-DILI-Net].