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Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data (2023)
Journal Article
Coates, G., Clewes, P., Lohan, C., Stevenson, H., Wood, R., Tritton, T., …Walsh, D. (2023). Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data. BMJ Open, 13(7), Article e067545. https://doi.org/10.1136/bmjopen-2022-067545

Objective: Despite the prevalence of osteoarthritis (OA) in England, few studies have examined the health economic impact of chronic pain associated with OA. The aim of this study was to compare outcomes in patients with moderate-to-severe chronic pa... Read More about Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data.

Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis (2023)
Journal Article
Liu, S., Athar, A., Quach, D., Patanwala, A. E., Naylor, J. M., Stevens, J. A., …Penm, J. (2023). Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis. Anaesthesia, 78(10), 1225-1236. https://doi.org/10.1111/anae.16085

Prescription of modified-release opioids for acute postoperative pain is widespread despite evidence to show their use may be associated with an increased risk of adverse effects. This systematic review and meta-analysis aimed to examine the availabl... Read More about Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis.

Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET (2023)
Journal Article
Van Daele, M., Kilpatrick, L. E., Woolard, J., & Hill, S. J. (2023). Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET. Biochemical Pharmacology, 214, Article 115672. https://doi.org/10.1016/j.bcp.2023.115672

Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis, proliferation and migration of vascular endothelial cells. It is well known that cardiovascular safety liability for a wide range of small molecule tyrosine kinase in... Read More about Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET.

Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells (2023)
Journal Article
Ogrodzinski, L., Platt, S., Goulding, J., Alexander, C., Farr, T. D., Woolard, J., …Kilpatrick, L. E. (2023). Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells. iScience, 26(7), Article 107232. https://doi.org/10.1016/j.isci.2023.107232

E-selectin is expressed on endothelial cells in response to inflammatory cytokines and mediates leukocyte rolling and extravasation. However, studies have been hampered by lack of experimental approaches to monitor expression in real time in living c... Read More about Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells.

Electrochemical Immunosensor for Ultra-Low Detection of Human Papillomavirus Biomarker for Cervical Cancer (2023)
Journal Article
Peteni, S., Ozoemena, O. C., Khawula, T., Haruna, A. B., Rawson, F. J., Shai, L. J., …Ozoemena, K. I. (2023). Electrochemical Immunosensor for Ultra-Low Detection of Human Papillomavirus Biomarker for Cervical Cancer. ACS Sensors, 8(7), 2761-2770. https://doi.org/10.1021/acssensors.3c00677

Human papillomavirus (HPV) is the causative agent for cervical cancer. Of the various types of HPV, the high-risk HPV-16 type is the most important antigenic high-risk HPV. In this work, the antigenic HPV-16 L1 peptide was immobilized on a glassy car... Read More about Electrochemical Immunosensor for Ultra-Low Detection of Human Papillomavirus Biomarker for Cervical Cancer.

Impact of modified-release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score-matched cohort study (2023)
Journal Article
Liu, S., Patanwala, A. E., Naylor, J. M., Levy, N., Knaggs, R., Stevens, J. A., …Penm, J. (2023). Impact of modified-release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score-matched cohort study. Anaesthesia, 78(10), 1237-1248. https://doi.org/10.1111/anae.16070

Modified-release opioids are often prescribed for the management of moderate to severe acute pain following total hip and knee arthroplasty, despite recommendations against their use due to increasing concerns regarding harm. The primary objective of... Read More about Impact of modified-release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score-matched cohort study.

Dual roles of demethylation in cancer treatment and cardio-function recovery (2023)
Journal Article
Li, X., Shen, D., Zhu, Z., Lyu, D., He, C., Sun, Y., …Wang, G. (2023). Dual roles of demethylation in cancer treatment and cardio-function recovery. Redox Biology, 64, Article 102785. https://doi.org/10.1016/j.redox.2023.102785

There are no effective therapeutic targets or strategies that simultaneously inhibit tumour growth and promote cardiac function recovery. Here, we analyzed targets for cancer treatments and cardiac repair, with demethylation emerging as a common fact... Read More about Dual roles of demethylation in cancer treatment and cardio-function recovery.

Odd–even disparity in the population of slipped hairpins in RNA repeat sequences with implications for phase separation (2023)
Journal Article
Maity, H., Nguyen, H. T., Hori, N., & Thirumalai, D. (2023). Odd–even disparity in the population of slipped hairpins in RNA repeat sequences with implications for phase separation. Proceedings of the National Academy of Sciences, 120(24), Article e2301409120. https://doi.org/10.1073/pnas.2301409120

Low-complexity nucleotide repeat sequences, which are implicated in several neurological disorders, undergo liquid–liquid phase separation (LLPS) provided the number of repeat units, n, exceeds a critical value. Here, we establish a link between the... Read More about Odd–even disparity in the population of slipped hairpins in RNA repeat sequences with implications for phase separation.

Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England (2023)
Journal Article
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R. D., & Lobo, D. N. (2023). Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England. Anaesthesia, 78(9), 1081-1092. https://doi.org/10.1111/anae.16055

This retrospective cohort study on adults undergoing colectomy from 2010 to 2019 used linked primary (Clinical Practice Research Datalink), and secondary (Hospital Episode Statistics) care data to determine the prevalence of persistent postoperative... Read More about Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England.

Dissociative Host-Dopant Bonding Facilitates Molecular Doping in Halide Perovskites (2023)
Journal Article
Lanzetta, L., Gregori, L., Hernandez, L. H., Sharma, A., Kern, S., Kotowska, A. M., …Baran, D. (2023). Dissociative Host-Dopant Bonding Facilitates Molecular Doping in Halide Perovskites. ACS Energy Letters, 8, 2858-2867. https://doi.org/10.1021/acsenergylett.3c00818

Molecular doping is a promising strategy to fine-tune the electronic properties of halide perovskites and accelerate their implementation as next-generation optoelectronics. However, a deeper understanding of the role of host-dopant interactions in t... Read More about Dissociative Host-Dopant Bonding Facilitates Molecular Doping in Halide Perovskites.

Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships (2023)
Journal Article
Myers, B., Catrambone, F., Allen, S., Hill, P. J., Kovacs, K., & Rawson, F. J. (2023). Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships. Scientific Reports, 13(1), Article 8843. https://doi.org/10.1038/s41598-023-35553-2

Bacterial pilin nanowires are protein complexes, suggested to possess electroactive capabilities forming part of the cells’ bioenergetic programming. Their role is thought to be linked to facilitating electron transfer between cells and the external... Read More about Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships.

Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS (2023)
Journal Article
Khateb, H., Hook, A. L., Kern, S., Watts, J. A., Singh, S., Jackson, D., …Alexander, M. R. (2023). Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS. Biointerphases, 18(3), Article 031007. https://doi.org/10.1116/6.0002604

Secondary ion mass spectrometry (SIMS) offers advantages over both liquid extraction mass spectrometry and matrix assisted laser desorption mass spectrometry in that it provides the direct in situ analysis of molecules and has the potential to preser... Read More about Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS.

Discovery of new imidazotetrazinones with potential to overcome tumor resistance (2023)
Journal Article
Summers, H. S., Lewis, W., Williams, H. E. L., Bradshaw, T. D., Moody, C. J., & Stevens, M. F. G. (2023). Discovery of new imidazotetrazinones with potential to overcome tumor resistance. European Journal of Medicinal Chemistry, 257, Article 115507. https://doi.org/10.1016/j.ejmech.2023.115507

We describe the design, organic synthesis, and characterization, including X-ray crystallography, of a series of novel analogues of the clinically used antitumor agent temozolomide, together with their in vitro biological evaluation. The work has res... Read More about Discovery of new imidazotetrazinones with potential to overcome tumor resistance.

Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo (2023)
Journal Article
Zhu, H., Zhu, W., Liu, Y., Gao, T., Zhu, J., Tan, Y., …Xu, S. (2023). Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo. European Journal of Medicinal Chemistry, 257, Article 115529. https://doi.org/10.1016/j.ejmech.2023.115529

A series of novel stilbene-based derivatives were designed and synthesized as tubulin/HDAC dual-target inhibitors. Among forty-three target compounds, compound II-19k not only exhibited considerable antiproliferative activity in the hematological cel... Read More about Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo.

Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation (2023)
Journal Article
Feng, Z., Cheng, Y., Khlyustova, A., Wani, A., Franklin, T., Varner, J. D., …Yang, R. (2023). Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation. Advanced Materials Technologies, 8(13), Article 2201533. https://doi.org/10.1002/admt.202201533

Amphiphilic copolymers (AP) represent a class of novel antibiofouling materials whose chemistry and composition can be tuned to optimize their performance. However, the enormous chemistry-composition design space associated with AP makes their perfor... Read More about Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation.

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes (2023)
Journal Article
Lay, C. S., Isidro-Llobet, A., Kilpatrick, L. E., Craggs, P. D., & Hill, S. J. (2023). Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes. Nature Communications, 14, Article 2882. https://doi.org/10.1038/s41467-023-38541-2

Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets. Successful antibody-based therapies direct... Read More about Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes.

Evolution of the pore structure-transport relationship during catalyst reduction and sintering studied by integrated multi-scale porosimetry and multi-modal imaging (2023)
Journal Article
Mousa, S., Novak, V., Fletcher, R. S., Kelly, G., Garcia, M., Macleod, N., …Rigby, S. P. (2023). Evolution of the pore structure-transport relationship during catalyst reduction and sintering studied by integrated multi-scale porosimetry and multi-modal imaging. Chemical Engineering Science, 277, Article 118880. https://doi.org/10.1016/j.ces.2023.118880

Catalyst pellet fabrication parameters significantly impact final product performance. Tabletted pellets are complex, hierarchical structures that evolve differently over various levels during subsequent processing. Multi-scale porosimetry and multi-... Read More about Evolution of the pore structure-transport relationship during catalyst reduction and sintering studied by integrated multi-scale porosimetry and multi-modal imaging.

Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility (2023)
Journal Article
Xue, R., Deng, X., Xu, X., Tian, Y., Hasan, A., Mata, A., …Liu, L. (2023). Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility. Biomaterials Advances, 151, Article 213471. https://doi.org/10.1016/j.bioadv.2023.213471

The biocompatibility of biomedical materials is vital to their applicability and functionality. However, modifying surfaces for enhanced biocompatibility using traditional surface treatment techniques is challenging. We employed a mineralizing elasti... Read More about Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility.

Development of biocide coated polymers and their antimicrobial efficacy (2023)
Journal Article
Watson, R., Maxwell, M., Dunn, S., Brooks, A., Jiang, L., Hill, H. J., …de Cogan, F. (2023). Development of biocide coated polymers and their antimicrobial efficacy. Nano Select, 4(7), 442-453. https://doi.org/10.1002/nano.202300005

Microbial contamination of plastic surfaces is a significant source of hospital‐acquired infections. To produce antimicrobial surfaces, chlorhexidine was attached to nitrided acrylonitrile butadiene styrene (ABS). The uniformity of chlorhexidine dist... Read More about Development of biocide coated polymers and their antimicrobial efficacy.