All Outputs (138)

Opioid prescription at postoperative discharge: a retrospective observational cohort study (2021)
Journal Article

Opioid misuse is now considered a major public health epidemic in North America, with substantial social and financial consequences. As well as socio-economic and commercial drivers, modifiable risk-factors that have resulted in this crisis have been... Read More about Opioid prescription at postoperative discharge: a retrospective observational cohort study.

Qualitative and quantitative methods show stability in patterns of Cepaea nemoralis shell polymorphism in the Pyrenees over five decades (2021)
Journal Article

Over the past century, the study of animal color has been critical in establishing some of the founding principles of biology, especially in genetics and evolution. In this regard, one of the emerging strengths of working with the land snail genus Ce... Read More about Qualitative and quantitative methods show stability in patterns of Cepaea nemoralis shell polymorphism in the Pyrenees over five decades.

Efficient G protein coupling is not required for agonist?mediated internalization and membrane reorganization of the adenosine A 3 receptor (2021)
Journal Article

Organization of G protein-coupled receptors at the plasma membrane has been the focus of much recent attention. Advanced microscopy techniques have shown that these receptors can be localized to discrete microdomains and reorganization upon ligand ac... Read More about Efficient G protein coupling is not required for agonist?mediated internalization and membrane reorganization of the adenosine A 3 receptor.

Metabolic signatures of osteoarthritis in urine using liquid chromatography?high resolution tandem mass spectrometry (2021)
Journal Article

Introduction: Osteoarthritis (OA) is a common cause of disability in older people, but its aetiology is not yet fully understood. Biomarkers of OA from metabolomics studies have shown potential use in understanding the progression and pathophysiology... Read More about Metabolic signatures of osteoarthritis in urine using liquid chromatography?high resolution tandem mass spectrometry.

Foraging aggressiveness determines trophic niche in a generalist biological control species (2021)
Journal Article

There is a growing evidence that consistent interindividual differences in behavior, that is, behavioral types, can play an important role in key ecological processes such as predator–prey interactions, which in turn can have direct implications on b... Read More about Foraging aggressiveness determines trophic niche in a generalist biological control species.

3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination (2021)
Journal Article

© 2021, The Author(s). Studying medulloblastoma, the most common malignant paediatric brain tumour, requires simple yet realistic in vitro models. In this study, we optimised a robust, reliable, three-dimensional (3D) culture method for medulloblasto... Read More about 3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination.

Age group determines the acceptability of protein derived off-flavour (2021)
Journal Article

© 2021 The Authors Many older adults fail to meet their daily protein requirements, potentially due to social, physical and medical factors, including sensory and appetite changes. Additionally, our previous research has identified potential sulfurou... Read More about Age group determines the acceptability of protein derived off-flavour.

Evolving challenges and strategies for fungal control in the food supply chain (2021)
Journal Article

Fungi that spoil foods or infect crops can have major socioeconomic impacts, posing threats to food security. The strategies needed to manage these fungi are evolving, given the growing incidence of fungicide resistance, tightening regulations of che... Read More about Evolving challenges and strategies for fungal control in the food supply chain.

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage (2021)
Journal Article

Investigations of the human germline and programming are challenging because of limited access to embryonic material. However, the pig as a model may provide insights into transcriptional network and epigenetic reprogramming applicable to both specie... Read More about Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage.

Time or place? Dissociation between object-in-place and relative recency in young APPswe/PS1dE9 mice. (2021)
Journal Article

This study tests the predictions of a novel analysis of recognition memory based on a theory of associative learning, according to which recognition comprises two independent underlying processes, one relying on the to-be-recognized item having been... Read More about Time or place? Dissociation between object-in-place and relative recency in young APPswe/PS1dE9 mice..

Molecular phylogeny of the orthurethra (panpulmonata: Stylommatophora) (2021)
Journal Article

We have undertaken a molecular analysis of the Orthurethra, one of the major groups of stylommatophoran land snails and slugs. Approximately 4000 nucleotides of the rRNA gene cluster [5.8S, internal transcribed spacer 2 (ITS2) and almost the full-len... Read More about Molecular phylogeny of the orthurethra (panpulmonata: Stylommatophora).

A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Elevated circulating branched-chain amino acids (BCAAs; isoleucine, leucine, and valine) are associated with obesity and type 2 diabetes (T2D). Reducing circulatory BCAAs by dietary restrictio... Read More about A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes.

Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach (2020)
Journal Article

Stat3 oxidation-dependent regulation of gene expression impacts on developmental processes and involves cooperation with Hif-1? (2020)
Journal Article

© 2020 Grillo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More about Stat3 oxidation-dependent regulation of gene expression impacts on developmental processes and involves cooperation with Hif-1?.

The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo (2020)
Journal Article

Key points: Reduced vitamin D receptor (VDR) expression prompts skeletal muscle atrophy. Atrophy occurs through catabolic processes, namely the induction of autophagy, while anabolism remains unchanged. In response to VDR-knockdown mitochondrial func... Read More about The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo.

Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells (2020)
Journal Article

© 2020, The Author(s). To study the localisation of G protein-coupled receptors (GPCR) in their native cellular environment requires their visualisation through fluorescent labelling. To overcome the requirement for genetic modification of the recept... Read More about Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells.

The Sustainable Path to a Circular Bioeconomy (2020)
Journal Article

Circular bioeconomy is gaining prominence in academic, policy, and industry contexts, linking circular economy and bioeconomy agendas in service of sustainability. However, it is at risk of developing in narrow, unsustainable ways. A sustainable path... Read More about The Sustainable Path to a Circular Bioeconomy.

Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock (2020)
Journal Article

© 2020, The Author(s). Geoffrey Burnstock made groundbreaking discoveries on the physiological roles of purinergic receptors and led on P2 purinergic receptor classification. His knowledge, vision and leadership inspired and influenced the internatio... Read More about Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock.

Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens (2020)
Journal Article

With the spread of drug resistance, new antimicrobials are urgently needed. Here, we set out to tackle this problem by high-throughput exploration for novel antifungal synergies among combinations of approved, nonantifungal drugs; a novel strategy ex... Read More about Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens.

Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation (2020)
Journal Article

Introduction: Inflammation during the neonatal period can exacerbate pain severity following reinjury in adulthood. This is driven by alterations in the postnatal development of spinal and supraspinal nociceptive circuitry. However, the contribution... Read More about Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation.