All Outputs (259)

Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions (2021)
Journal Article
Tomi-Andrino, C., Norman, R., Millat, T., Soucaille, P., Winzer, K., Barrett, D. A., King, J., & Kim, D.-H. (2021). Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions. PLoS Computational Biology, 17(1), Article e1007694. https://doi.org/10.1371/journal.pcbi.1007694

© 2021 Tomi-Andrino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source a... Read More about Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions.

AbaM Regulates Quorum Sensing, Biofilm Formation and Virulence in Acinetobacter baumannii (2021)
Journal Article
López-Martín, M., Dubern, J.-F., Alexander, M. R., & Williams, P. (2021). AbaM Regulates Quorum Sensing, Biofilm Formation and Virulence in Acinetobacter baumannii. Journal of Bacteriology, 203(8), Article e00635-20. https://doi.org/10.1128/jb.00635-20

Acinetobacter baumannii possesses a single divergent luxR/luxI-type quorum sensing (QS) locus named abaR/abaI. This locus also contains a third gene located between abaR and abaI which we term abaM that codes for an uncharacterized member of the RsaM... Read More about AbaM Regulates Quorum Sensing, Biofilm Formation and Virulence in Acinetobacter baumannii.

Investigation of Receptor Heteromers Using NanoBRET Ligand Binding (2021)
Journal Article
Johnstone, E. K. M., See, H. B., Abhayawardana, R. S., Song, A., Rosengren, K. J., Hill, S. J., & Pfleger, K. D. G. (2021). Investigation of Receptor Heteromers Using NanoBRET Ligand Binding. International Journal of Molecular Sciences, 22(3), Article 1082. https://doi.org/10.3390/ijms22031082

Receptor heteromerization is the formation of a complex involving at least two different receptors with pharmacology that is distinct from that exhibited by its constituent receptor units. Detection of these complexes and monitoring their pharmacolog... Read More about Investigation of Receptor Heteromers Using NanoBRET Ligand Binding.

Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo (2021)
Journal Article
Awuah-Mensah, G., McDonald, J., Steketee, P. C., Autheman, D., Whipple, S., D'Archivio, S., Brandt, C., Clare, S., Harcourt, K., Wright, G. J., Morrison, L. J., Gadelha, C., & Wickstead, B. (2021). Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo. PLoS Pathogens, 17(1), Article e1009224. https://doi.org/10.1371/journal.ppat.1009224

Copyright: © 2021 Awuah-Mensah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author a... Read More about Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo.

Maintenance of Adaptive Dynamics and No Detectable Load in a Range-Edge Outcrossing Plant Population (2021)
Journal Article
Takou, M., Hämälä, T., Koch, E. M., Steige, K. A., Dittberner, H., Yant, L., Genete, M., Sunyaev, S., Castric, V., Vekemans, X., Savolainen, O., & Meaux, J. D. (2021). Maintenance of Adaptive Dynamics and No Detectable Load in a Range-Edge Outcrossing Plant Population. Molecular Biology and Evolution, 38(5), 1820-1836. https://doi.org/10.1093/molbev/msaa322

During range expansion, edge populations are expected to face increased genetic drift, which in turn can alter and potentially compromise adaptive dynamics, preventing the removal of deleterious mutations and slowing down adaptation. Here, we contras... Read More about Maintenance of Adaptive Dynamics and No Detectable Load in a Range-Edge Outcrossing Plant Population.

Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study (2021)
Preprint / Working Paper
Blake, H., Knight, H., Jia, R., Corner, J., Morling, J. R., Denning, C., Ball, J. K., Bolton, K., Figeuredo, G., Morris, D., Tighe, P., Villalon, A., Ayling, K., & Vedhara, K. Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups conduc... Read More about Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study.

Predatory bacteria as living antibiotics – where are we now? (2021)
Journal Article
Atterbury, R. J., & Tyson, J. (2021). Predatory bacteria as living antibiotics – where are we now?. Microbiology, 167(1), Article 001025. https://doi.org/10.1099/mic.0.001025

Antimicrobial resistance (AMR) is a global health and economic crisis. With too few antibiotics in development to meet current and anticipated needs, there is a critical need for new therapies to treat Gram-negative infections. One potential approach... Read More about Predatory bacteria as living antibiotics – where are we now?.

A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men (2021)
Journal Article
Brook, M., Scaife, P., Bass, J., Cegielski, J., Watanabe, S., Wilkinson, D., Smith, K., Phillips, B., & Atherton, P. (2021). A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men. Clinical Nutrition, 40(6), 4456-4464. https://doi.org/10.1016/j.clnu.2021.01.002

Background & aims: Nutritional composition is key for skeletal muscle maintenance into older age. Yet the acute effects of collagen protein blended with other protein sources, in relation to skeletal muscle anabolism, are ill-defined. We investigated... Read More about A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men.

The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core (2021)
Journal Article
Jenkins, T., Northall, S. J., Ptchelkine, D., Lever, R., Cubbon, A., Betts, H., Taresco, V., Cooper, C. D. O., McHugh, P. J., Soultanas, P., & Bolt, E. L. (2021). The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core. NAR Cancer, 3(1), Article zcaa043. https://doi.org/10.1093/narcan/zcaa043

Genome instability is a characteristic enabling factor for carcinogenesis. HelQ helicase is a component of human DNA maintenance systems that prevent or reverse genome instability arising during DNA replication. Here, we provide details of the molecu... Read More about The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core.

The draft genome sequence of the grove snail Cepaea nemoralis (2021)
Journal Article
Saenko, S. V., Groenenberg, D. S., Davison, A., & Schilthuizen, M. (2021). The draft genome sequence of the grove snail Cepaea nemoralis. G3, 11(2), Article jkaa071. https://doi.org/10.1093/g3journal/jkaa071

© The Author(s) 2021. Studies on the shell color and banding polymorphism of the grove snail Cepaea nemoralis and the sister taxon Cepaea hortensis have provided compelling evidence for the fundamental role of natural selection in promoting and maint... Read More about The draft genome sequence of the grove snail Cepaea nemoralis.

Prevalence of comorbidities and their associated factors in patients with type 2 diabetes at a tertiary care department in Ningbo, China: a cross-sectional study (2021)
Journal Article
Li, X., Chattopadhyay, K., Xu, S., Chen, Y., Xu, M., Li, L., & Li, J. (2021). Prevalence of comorbidities and their associated factors in patients with type 2 diabetes at a tertiary care department in Ningbo, China: a cross-sectional study. BMJ Open, 11(1), Article e040532. https://doi.org/10.1136/bmjopen-2020-040532

Objectives: To determine the prevalence of comorbidities in patients with type 2 diabetes (T2DM) and identify the factors independently associated with comorbidities in a tertiary care department in Ningbo, China.

Design: A computerised medical re... Read More about Prevalence of comorbidities and their associated factors in patients with type 2 diabetes at a tertiary care department in Ningbo, China: a cross-sectional study.

Ion channel profiling of the Lymnaea stagnalis ganglia via transcriptome analysis (2021)
Journal Article
Dong, N., Bandura, J., Zhang, Z., Wang, Y., Labadie, K., Noel, B., Davison, A., Koene, J. M., Sun, H. S., Coutellec, M. A., & Feng, Z. P. (2021). Ion channel profiling of the Lymnaea stagnalis ganglia via transcriptome analysis. BMC Genomics, 22, Article 18. https://doi.org/10.1186/s12864-020-07287-2

© 2021, The Author(s). Background: The pond snail Lymnaea stagnalis (L. stagnalis) has been widely used as a model organism in neurobiology, ecotoxicology, and parasitology due to the relative simplicity of its central nervous system (CNS). However,... Read More about Ion channel profiling of the Lymnaea stagnalis ganglia via transcriptome analysis.

Integration of diverse DNA substrates by a casposase can be targeted to R-loops in vitro by its fusion to Cas9 (2021)
Journal Article
Lau, C. H., & Bolt, E. L. (2021). Integration of diverse DNA substrates by a casposase can be targeted to R-loops in vitro by its fusion to Cas9. Bioscience Reports, 41(1), Article BSR20203595. https://doi.org/10.1042/bsr20203595

CRISPR systems build adaptive immunity against mobile genetic elements by DNA capture and integration catalysed by Cas1–Cas2 protein complexes. Recent studies suggested that CRISPR repeats and adaptation module originated from a novel type of DNA tra... Read More about Integration of diverse DNA substrates by a casposase can be targeted to R-loops in vitro by its fusion to Cas9.

ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25 (2021)
Journal Article
Quintero-Barceinas, R. S., Gehringer, F., Ducker, C., Saxton, J., & Shaw, P. E. (2021). ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25. Journal of Biological Chemistry, 296, Article 100214. https://doi.org/10.1074/jbc.ra120.014616

The mitogen-responsive, ETS-domain transcription factor ELK-1 stimulates the expression of immediate early genes at the onset of the cell cycle and participates in early developmental programming. ELK-1 is subject to multiple levels of posttranslatio... Read More about ELK-1 ubiquitination status and transcriptional activity are modulated independently of F-Box protein FBXO25.

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function (2021)
Journal Article
Barnes, N. M., Ahern, G. P., Becamel, C., Bockaert, J., Camilleri, M., Chaumont-Dubel, S., Claeysen, S., Cunningham, K. A., Fone, K. C., Gershon, M., Di Giovanni, G., Goodfellow, N. M., Halberstadt, A. L., Hartley, R. M., Hassaine, G., Herrick-Davis, K., Hovius, R., Lacivita, E., Lambe, E. K., Leopoldo, M., …Hoyer, D. (2021). International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacological Reviews, 73(1), 310-520. https://doi.org/10.1124/pr.118.015552

Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics. 5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and fu... Read More about International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.

AhaP, A Quorum Quenching Acylase from Psychrobacter sp. M9-54-1 That Attenuates Pseudomonas aeruginosa and Vibrio coralliilyticus Virulence (2021)
Journal Article
Reina, J. C., Romero, M., Salto, R., Cámara, M., & Llamas, I. (2021). AhaP, A Quorum Quenching Acylase from Psychrobacter sp. M9-54-1 That Attenuates Pseudomonas aeruginosa and Vibrio coralliilyticus Virulence. Marine Drugs, 19(1), Article 16. https://doi.org/10.3390/md19010016

Although Psychrobacter strain M9-54-1 had been previously isolated from the microbiota of holothurians and shown to degrade quorum sensing (QS) signal molecules C6 and C10-homoserine lactone (HSL), little was known about the gene responsible for this... Read More about AhaP, A Quorum Quenching Acylase from Psychrobacter sp. M9-54-1 That Attenuates Pseudomonas aeruginosa and Vibrio coralliilyticus Virulence.

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes (2021)
Journal Article
Mai, Q. N., Shenoy, P., Quach, T., Retamal, J. S., Gondin, A. B., Yeatman, H. R., Aurelio, L., Conner, J. W., Poole, D. P., Canals, M., Nowell, C. J., Graham, B., Davis, T. P., Briddon, S. J., Hill, S. J., Porter, C. J., Bunnett, N. W., Halls, M. L., & Veldhuis, N. A. (2021). A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes. Journal of Biological Chemistry, 296, Article 100345. https://doi.org/10.1016/J.JBC.2021.100345

G-protein-coupled receptors (GPCRs) are traditionally known for signaling at the plasma membrane, but they can also signal from endosomes after internalization to control important pathophysiological processes. In spinal neurons, sustained endosomal... Read More about A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.

Nitrergic modulation of ion channel function in regulating neuronal excitability (2021)
Journal Article
Spiers, J. G., & Steinert, J. R. (2021). Nitrergic modulation of ion channel function in regulating neuronal excitability. Channels, 15(1), 666-679. https://doi.org/10.1080/19336950.2021.2002594

Nitric oxide (NO) signaling in the brain provides a wide range of functional properties in response to neuronal activity. NO exerts its effects through different signaling pathways, namely, through the canonical soluble guanylyl cyclase-mediated cGMP... Read More about Nitrergic modulation of ion channel function in regulating neuronal excitability.

ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma (2021)
Journal Article
Nasir, A., Cardall, A., Othman, R. T., Nicolaou, N., Lourdusamy, A., Linke, F., Onion, D., Ryzhova, M., Cameron, H., Valente, C., Korshunov, A., Pfister, S. M., Grabowska, A. M., Kerr, I. D., & Coyle, B. (2021). ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma. Neuro-Oncology Advances, 3(1), https://doi.org/10.1093/noajnl/vdab030

Background: Therapeutic intervention in metastatic medulloblastoma is dependent upon elucidating the underlying metastatic mechanism. We investigated whether an epithelialmesenchymal transition (EMT)-like pathway could drive medulloblastoma metastasi... Read More about ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.