Nicholas M. Barnes
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
Barnes, Nicholas M.; Ahern, Gerard P.; Becamel, Carine; Bockaert, Jo�l; Camilleri, Michael; Chaumont-Dubel, Severine; Claeysen, Sylvie; Cunningham, Kathryn A.; Fone, Kevin C.; Gershon, Michael; Di Giovanni, Giuseppe; Goodfellow, Nathalie M.; Halberstadt, Adam L.; Hartley, Rachel M.; Hassaine, Gh�rici; Herrick-Davis, Katharine; Hovius, Ruud; Lacivita, Enza; Lambe, Evelyn K.; Leopoldo, Marcello; Levy, Finn Olav; Lummis, Sarah C.R.; Marin, Philippe; Maroteaux, Luc; McCreary, Andrew C.; Nelson, David L.; Neumaier, John F.; Newman-Tancredi, Adrian; Nury, Hugues; Roberts, Alexander; Roth, Bryan L.; Roumier, Anne; Sanger, Gareth J.; Teitler, Milt; Sharp, Trevor; Villal�n, Carlos M.; Vogel, Horst; Watts, Stephanie W.; Hoyer, Daniel
Authors
Gerard P. Ahern
Carine Becamel
Jo�l Bockaert
Michael Camilleri
Severine Chaumont-Dubel
Sylvie Claeysen
Kathryn A. Cunningham
Kevin C. Fone
Michael Gershon
Giuseppe Di Giovanni
Nathalie M. Goodfellow
Adam L. Halberstadt
Rachel M. Hartley
Gh�rici Hassaine
Katharine Herrick-Davis
Ruud Hovius
Enza Lacivita
Evelyn K. Lambe
Marcello Leopoldo
Finn Olav Levy
Sarah C.R. Lummis
Philippe Marin
Luc Maroteaux
Andrew C. McCreary
David L. Nelson
John F. Neumaier
Adrian Newman-Tancredi
Hugues Nury
Alexander Roberts
Bryan L. Roth
Anne Roumier
Gareth J. Sanger
Milt Teitler
Trevor Sharp
Carlos M. Villal�n
Horst Vogel
Stephanie W. Watts
Daniel Hoyer
Abstract
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics. 5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors. SIGNIFICANCE STATEMENT: This review provides a comprehensive account of the classification and function of 5-hydroxytryptamine receptors, including how they are targeted for therapeutic benefit.
Citation
Barnes, N. M., Ahern, G. P., Becamel, C., Bockaert, J., Camilleri, M., Chaumont-Dubel, S., …Hoyer, D. (2021). International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacological Reviews, 73(1), 310-520. https://doi.org/10.1124/pr.118.015552
| Journal Article Type | Review |
|---|---|
| Acceptance Date | Dec 22, 2020 |
| Online Publication Date | Jan 1, 2021 |
| Publication Date | Jan 1, 2021 |
| Deposit Date | May 6, 2021 |
| Journal | Pharmacological reviews |
| Print ISSN | 0031-6997 |
| Electronic ISSN | 1521-0081 |
| Publisher | American Society for Pharmacology and Experimental Therapeutics |
| Peer Reviewed | Peer Reviewed |
| Volume | 73 |
| Issue | 1 |
| Pages | 310-520 |
| DOI | https://doi.org/10.1124/pr.118.015552 |
| Public URL | https://nottingham-repository.worktribe.com/output/5229068 |
| Publisher URL | https://pharmrev.aspetjournals.org/content/73/1/310 |
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