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All Outputs (260)

Hypoalbuminemia in patients following their recovery from severe coronavirus disease 2019 (2021)
Journal Article
Ali, K. M., Ali, A. M., Tawfeeq, H. M., Figueredo, G. P., & Rostam, H. M. (2021). Hypoalbuminemia in patients following their recovery from severe coronavirus disease 2019. Journal of Medical Virology, 93(7), 4532-4536. https://doi.org/10.1002/jmv.27002

Coronavirus disease 2019 (COVID-19) is caused by a contagious virus that has spread to more than 200 countries, territories, and regions. Thousands of studies to date have examined all aspects of this disease, yet little is known about the postrecove... Read More about Hypoalbuminemia in patients following their recovery from severe coronavirus disease 2019.

Exploring wellbeing in first year medical students amidst a curriculum change (2021)
Journal Article
Merrick, D., Mbaki, Y., Pratten, M. K., & Simpson, T. G. (2021). Exploring wellbeing in first year medical students amidst a curriculum change. BMC Medical Education, 21, Article 252. https://doi.org/10.1186/s12909-021-02678-9

Background: The support of student wellbeing features highly in all higher education institutional agendas. For medical students good physical and mental health can help prevent burnout, equip students for their future healthcare setting and indirect... Read More about Exploring wellbeing in first year medical students amidst a curriculum change.

Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine (2021)
Journal Article
Jalanka, J., Lam, C., Bennett, A., Hartikainen, A., Crispie, F., Finnegan, L. A., Cotter, P. D., & Spiller, R. (2021). Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine. Journal of Neurogastroenterology and Motility, 27(2), 279-291. https://doi.org/10.5056/JNM20205

Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammator... Read More about Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine.

Molecular modifications of the pseudomonas quinolone signal in the intermicrobial competition with aspergillus (2021)
Journal Article
Nazik, H., Sass, G., Williams, P., Déziel, E., & Stevens, D. A. (2021). Molecular modifications of the pseudomonas quinolone signal in the intermicrobial competition with aspergillus. Journal of Fungi, 7(5), Article 343. https://doi.org/10.3390/jof7050343

The Pseudomonas quinolone signal (PQS) is an important quorum-sensing molecule for Pseudomonas aeruginosa that regulates virulence factors, chelates iron, and is an important factor in interactions with eukaryotes, including fungi and mammalian hosts... Read More about Molecular modifications of the pseudomonas quinolone signal in the intermicrobial competition with aspergillus.

Characterization of neuronal viability and network activity under microfluidic flow (2021)
Journal Article
Herzog, N., Johnstone, A., Bellamy, T., & Russell, N. (2021). Characterization of neuronal viability and network activity under microfluidic flow. Journal of Neuroscience Methods, 358, Article 109200. https://doi.org/10.1016/j.jneumeth.2021.109200

Background: Microfluidics technology has the potential to allow precise control of the temporal and spatial aspects of solute concentration, making it highly relevant for the study of volume transmission mechanisms in neural tissue. However, full uti... Read More about Characterization of neuronal viability and network activity under microfluidic flow.

NirA Is an Alternative Nitrite Reductase from Pseudomonas aeruginosa with Potential as an Antivirulence Target (2021)
Journal Article
Fenn, S., Dubern, J.-F., Cigana, C., De Simone, M., Lazenby, J., Juhas, M., Schwager, S., Bianconi, I., Döring, G., Elmsley, J., Eberl, L., Williams, P., Bragonzi, A., & Cámara, M. (2021). NirA Is an Alternative Nitrite Reductase from Pseudomonas aeruginosa with Potential as an Antivirulence Target. mBio, 12(2), Article e00207-21. https://doi.org/10.1128/mbio.00207-21

The opportunistic pathogen Pseudomonas aeruginosa produces an arsenal of virulence factors causing a wide range of diseases in multiple hosts and is difficult to eradicate due to its intrinsic resistance to antibiotics. With the antibacterial pipelin... Read More about NirA Is an Alternative Nitrite Reductase from Pseudomonas aeruginosa with Potential as an Antivirulence Target.

Systematic assessment of chemokine signaling at chemokine receptors ccr4, ccr7 and ccr10 (2021)
Journal Article
Lim, H. D., Robert Lane, J., Canals, M., & Stone, M. J. (2021). Systematic assessment of chemokine signaling at chemokine receptors ccr4, ccr7 and ccr10. International Journal of Molecular Sciences, 22(8), Article 4232. https://doi.org/10.3390/ijms22084232

Chemokines interact with chemokine receptors in a promiscuous network, such that each receptor can be activated by multiple chemokines. Moreover, different chemokines have been reported to preferentially activate different signalling pathways via the... Read More about Systematic assessment of chemokine signaling at chemokine receptors ccr4, ccr7 and ccr10.

Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings (2021)
Journal Article
Steinmetz, N. A., Aydin, C., Lebedeva, A., Okun, M., Pachitariu, M., Bauza, M., Beau, M., Bhagat, J., Böhm, C., Broux, M., Chen, S., Colonell, J., Gardner, R. J., Karsh, B., Kloosterman, F., Kostadinov, D., Mora-Lopez, C., O’Callaghan, J., Park, J., Putzeys, J., …Harris, T. D. (2021). Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings. Science, 372(6539), Article eabf4588. https://doi.org/10.1126/science.abf4588

Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months. To address this need, we introduce the Neuropixels 2.0 probe together with newly designed a... Read More about Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings.

Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline (2021)
Journal Article
Shur, N. F., Creedon, L., Skirrow, S., Atherton, P. J., MacDonald, I. A., Lund, J., & Greenhaff, P. L. (2021). Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline. Ageing Research Reviews, 68, Article 101344. https://doi.org/10.1016/j.arr.2021.101344

In the United Kingdom (UK), it is projected that by 2035 people aged >65 years will make up 23 % of the population, with those aged >85 years accounting for 5% of the total population. Ageing is associated with progressive changes in muscle metabolis... Read More about Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline.

Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk. (2021)
Journal Article
Valdes, A. M., Moon, J. C., Vijay, A., Chaturvedi, N., Norrish, A., Ikram, A., Craxford, S., Cusin, L. M., Nightingale, J., Semper, A., Brooks, T., McKnight, A., Kurdi, H., Menni, C., Tighe, P., Noursadeghi, M., Aithal, G., Treibel, T. A., Ollivere, B. J., & Manisty, C. (2021). Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk. eClinicalMedicine, 34, 1-8. https://doi.org/10.1016/j.eclinm.2021.100835

Background:: Healthcare workers (HCWs) have increased rates of SARS-CoV-2 infection compared with the general population. We aimed to understand ethnic differences in SARS-CoV-2 seropositivity among hospital healthcare workers depending on their hosp... Read More about Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk..

New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling (2021)
Journal Article
Mann, A., Keen, A. C., Mark, H., Dasgupta, P., Javitch, J. A., Canals, M., Schulz, S., & Robert Lane, J. (2022). New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling. Scientific Reports, 11(1), Article 8288. https://doi.org/10.1038/s41598-021-87417-2

The dopamine D2 receptor (D2R) is the target of drugs used to treat the symptoms of Parkinson’s disease and schizophrenia. The D2R is regulated through its interaction with and phosphorylation by G protein receptor kinases (GRKs) and interaction with... Read More about New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling.

Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study (2021)
Journal Article
Blake, H., Knight, H., Jia, R., Corner, J., Morling, J. R., Denning, C., Ball, J. K., Bolton, K., Figeuredo, G., Morris, D., Tighe, P., Villalon, A. M., Ayling, K., & Vedhara, K. (2021). Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study. International Journal of Environmental Research and Public Health, 18(8), Article 4182. https://doi.org/10.3390/ijerph18084182

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation, during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups condu... Read More about Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study .

Combining Inducible Lectin Expression and Magnetic Glyconanoparticles for the Selective Isolation of Bacteria from Mixed Populations (2021)
Journal Article
Petch, J. E., Gurnani, P., Yilmaz, G., Mastrotto, F., Alexander, C., Heeb, S., Cámara, M., & Mantovani, G. (2021). Combining Inducible Lectin Expression and Magnetic Glyconanoparticles for the Selective Isolation of Bacteria from Mixed Populations. ACS Applied Materials and Interfaces, 13(16), 19230-19243. https://doi.org/10.1021/acsami.1c00907

The selective isolation of bacteria from mixed populations has been investigated in varied applications ranging from differential pathogen identification in medical diagnostics and food safety to the monitoring of microbial stress dynamics in industr... Read More about Combining Inducible Lectin Expression and Magnetic Glyconanoparticles for the Selective Isolation of Bacteria from Mixed Populations.

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank (2021)
Journal Article
Sandoval-Plata, G., Morgan, K., & Abhishek, A. (2021). Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank. Annals of the Rheumatic Diseases, 80(9), 1220-1226. https://doi.org/10.1136/annrheumdis-2020-219796

Objectives: To perform a genome-wide association study (GWAS) of gout cases vs. asymptomatic hyperuricaemia (AH) controls, and gout cases vs. normouricaemia controls, and to generate a polygenic risk score (PRS) to determine gout-case vs. AH-control... Read More about Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.

Magnesium and calcium overaccumulate in the leaves of a schengen3 mutant of Brassica rapa (2021)
Journal Article
Alcock, T. D., Thomas, C. L., Ó Lochlainn, S., Pongrac, P., Wilson, M., Moore, C., Reyt, G., Vogel-Mikuš, K., Kelemen, M., Hayden, R., Wilson, L., Stephenson, P., Østergaard, L., Irwin, J. A., Hammond, J. P., King, G. J., Salt, D. E., Graham, N. S., White, P. J., & Broadley, M. R. (2021). Magnesium and calcium overaccumulate in the leaves of a schengen3 mutant of Brassica rapa. Plant Physiology, 186(3), 1616-1631. https://doi.org/10.1093/PLPHYS/KIAB150

Magnesium (Mg) and calcium (Ca) are essential mineral nutrients poorly supplied in many human food systems. In grazing livestock, Mg and Ca deficiencies are costly welfare issues. Here, we report a Brassica rapa loss-of-function schengen3 (sgn3) muta... Read More about Magnesium and calcium overaccumulate in the leaves of a schengen3 mutant of Brassica rapa.

Mobilizing molluscan models and genomes in biology (2021)
Journal Article
Davison, A., & Neiman, M. (2021). Mobilizing molluscan models and genomes in biology. Philosophical Transactions B: Biological Sciences, 376(1825), Article 20200163. https://doi.org/10.1098/rstb.2020.0163

Molluscs are among the most ancient, diverse, and important of all animal taxa. Even so, no individual mollusc species has emerged as a broadly applied model system in biology. We here make the case that both perceptual and methodological barriers ha... Read More about Mobilizing molluscan models and genomes in biology.

Improved CRISPR/Cas9 Tools for the Rapid Metabolic Engineering of Clostridium acetobutylicum (2021)
Journal Article
Wilding-Steele, T., Ramette, Q., Jacottin, P., & Soucaille, P. (2021). Improved CRISPR/Cas9 Tools for the Rapid Metabolic Engineering of Clostridium acetobutylicum. International Journal of Molecular Sciences, 22(7), 1-11. https://doi.org/10.3390/ijms22073704

Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas (CRISPR-associated proteins)9 tools have revolutionized biology—several highly efficient tools have been constructed that have resulted in the ability to quickly engineer model ba... Read More about Improved CRISPR/Cas9 Tools for the Rapid Metabolic Engineering of Clostridium acetobutylicum.

Zebrafish as a tractable model of human cardiovascular disease (2021)
Journal Article
Bowley, G., Kugler, E., Wilkinson, R., Lawrie, A., Eeden, F., Chico, T. J. A., Evans, P. C., Noël, E. S., & Serbanovic‐Canic, J. (2022). Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology, 179(5), 900-917. https://doi.org/10.1111/bph.15473

Mammalian models including non-human primates, pigs and rodents have been used extensively to study the mechanisms of cardiovascular disease. However, there is an increasing desire for alternative model systems that provide excellent scientific value... Read More about Zebrafish as a tractable model of human cardiovascular disease.

Study Protocol: The Heart and Brain Study (2021)
Journal Article
Suri, S., Bulte, D., Chiesa, S. T., Ebmeier, K. P., Jezzard, P., Rieger, S. W., Pitt, J. E., Griffanti, L., Okell, T. W., Craig, M., Chappell, M. A., Blockley, N. P., Kivimäki, M., Singh-Manoux, A., Khir, A. W., Hughes, A. D., Deanfield, J. E., Jensen, D. E. A., Green, S. F., Sigutova, V., …Mackay, C. E. (2021). Study Protocol: The Heart and Brain Study. Frontiers in Physiology, 12, Article 643725. https://doi.org/10.3389/fphys.2021.643725

Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing... Read More about Study Protocol: The Heart and Brain Study.