All Outputs (343)

The impact of ageing on adults with cerebral palsy (2023)
Journal Article

Background Cerebral palsy (CP) is one of the most common neurological disorders in children and results in lifelong physical impairments. Adults with CP have approximately the same life expectancy as their non-disabled peers, so helping them to stay... Read More about The impact of ageing on adults with cerebral palsy.

Evaluating the UK's first national prescribing assessment for GPs in training using an online survey (2023)
Journal Article

Background GP trainees may not have experienced a systematic and comprehensive education in safe prescribing. Therefore, a self-assessment prescribing review was developed. Aim To determine whether the assessment was feasible, had face validity, a... Read More about Evaluating the UK's first national prescribing assessment for GPs in training using an online survey.

The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review (2023)
Journal Article

Background: Topical corticosteroids (TCS) are a first-line treatment for eczema, but there are concerns about their safety when used long-term. Objectives: To systematically review adverse effects associated with longer-term use of TCS for eczema. Me... Read More about The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review.

Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models (2023)
Journal Article

Background: Methods to identify patients at increased risk of oesophageal cancer are needed to better identify those for targeted screening. We aimed to derive and validate novel risk prediction algorithms (CanPredict) to estimate the 10-year risk of... Read More about Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models.

Emollients for preventing atopic eczema: Cost‐effectiveness analysis of the BEEP trial (2023)
Journal Article

Background Recent discoveries have led to the suggestion that enhancing skin barrier from birth might prevent eczema and food allergy. Objective To determine the cost‐effectiveness of daily all‐over‐body application of emollient during the firs... Read More about Emollients for preventing atopic eczema: Cost‐effectiveness analysis of the BEEP trial.

Evaluating the effect of child home safety training upon three family support practitioner groups: a mixed-methods study (2023)
Journal Article

Aims: Unintentional injuries in the home contribute substantially to preschool child morbidity and mortality. Practitioners such as health visitors, family mentors and children’s centre staff are well-positioned to facilitate child injury prevention... Read More about Evaluating the effect of child home safety training upon three family support practitioner groups: a mixed-methods study.

Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP): a qualitative study exploring trial team’s facilitators and challenges in conducting a feasibility trial in India (2023)
Journal Article

Background In India, around 77 million people are at high risk of developing type 2 diabetes mellitus (T2DM). Yoga interventions can be effective in preventing T2DM. We conducted a feasibility randomized controlled trial (RCT) in India, and the inte... Read More about Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP): a qualitative study exploring trial team’s facilitators and challenges in conducting a feasibility trial in India.

Forming a consensus opinion to inform long COVID support mechanisms and interventions: a modified Delphi approach. (2023)
Journal Article

Background: Current approaches to support patients living with post-COVID condition, also known as Long COVID, are highly disparate with limited success in managing or resolving a well-documented and long-standing symptom burden. With approximately 2... Read More about Forming a consensus opinion to inform long COVID support mechanisms and interventions: a modified Delphi approach..

The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap (2023)
Journal Article

Background Core outcome sets (COS) are consensus-driven sets of minimum outcomes that should be measured and reported in all clinical trials. COS aim to reduce heterogeneity in outcome measurement and reporting, and selective outcome reporting. Imple... Read More about The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap.

The relationship between reported daily nicotine dose from NRT and daily cigarette consumption in pregnant women who smoke in an observational cohort study (2023)
Journal Article

Introduction For non-pregnant people unable to quit smoking, the NHS recommends nicotine replacement therapy (NRT) for smoking reduction. This is not recommended during pregnancy due to concerns about higher nicotine intake than smoking alone. We inv... Read More about The relationship between reported daily nicotine dose from NRT and daily cigarette consumption in pregnant women who smoke in an observational cohort study.

Community pharmacy perspectives on managing skin conditions: Mixed methods online survey (2023)
Journal Article

Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study (2023)
Journal Article

Objectives To quantify mortality rates for patients successfully treated for hepatitis C in the era of interferon-free, direct acting antivirals and compare these rates with those of the general population. Design Population based cohort study.... Read More about Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study.

Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY (2023)
Journal Article

Background: In the UK, additional COVID-19 vaccine booster doses and treatments are offered to people who are immunosuppressed to protect against severe COVID-19, but how best to choose the individuals that receive these vaccine booster doses and tre... Read More about Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY.

Helping pregnant smokers quit: a multi-centre randomised controlled trial of electronic cigarettes versus nicotine replacement therapy (2023)
Journal Article

Background Some pregnant smokers try e-cigarettes, but effectiveness and safety of such use are unknown. Objectives To compare effectiveness and safety of nicotine patches and e-cigarettes in pregnancy. Design A pragmatic multi-centre random... Read More about Helping pregnant smokers quit: a multi-centre randomised controlled trial of electronic cigarettes versus nicotine replacement therapy.

Childhood bone tumours in primary care: helping GPs to identify ‘the needle in the haystack’ (2023)
Journal Article

In 2018, the World Health Organization declared childhood cancer as a global disease burden, launching a Global Initiative to improve survival to 60% worldwide by 2030. If achieved, it is estimated that an extra 1 million children’s lives will be sav... Read More about Childhood bone tumours in primary care: helping GPs to identify ‘the needle in the haystack’.

Managing raised ferritin in primary care (2023)
Journal Article

Evaluation of common prescription analgesics and adjuvant analgesics as markers of suicide risk: a longitudinal population-based study in England (2023)
Journal Article

Background: Analgesics prescriptions may provide a marker for identifying individuals at higher risk of suicide. In particular, awareness of which analgesics are implicated may help clinicians assess and modify risk. Method: A case–control study in E... Read More about Evaluation of common prescription analgesics and adjuvant analgesics as markers of suicide risk: a longitudinal population-based study in England.

Multinational prescribing trends of lithium from 2001 to 2019: a retrospective observational study using population-based databases from 17 countries and one special administrative region (2023)
Journal Article

Social determinants of health and vaccine uptake during the first wave of the COVID-19 pandemic: A systematic review (2023)
Journal Article

Social determinants of health significantly impact population health status. The aim of this systematic review was to examine which social vulnerability factors or determinants of health at the individual or county level affected vaccine uptake withi... Read More about Social determinants of health and vaccine uptake during the first wave of the COVID-19 pandemic: A systematic review.

How frequent is routine use of probiotics in UK neonatal units? (2023)
Journal Article

Objective There is a lack of UK guidance regarding routine use of probiotics in preterm infants to prevent necrotising enterocolitis, late-onset sepsis and death. As practices can vary, we aimed to determine the current usage of probiotics within neo... Read More about How frequent is routine use of probiotics in UK neonatal units?.