All Outputs (190)

COVID-19 infection, admission and death and the impact of corticosteroids amongst people with rare autoimmune rheumatic disease during the second wave of covid-19 in England: results from the RECORDER Project (2023)
Journal Article
Rutter, M., Lanyon, P. C., Grainge, M. J., Hubbard, R., Bythell, M., Stilwell, P., …Pearce, F. A. (2023). COVID-19 infection, admission and death and the impact of corticosteroids amongst people with rare autoimmune rheumatic disease during the second wave of covid-19 in England: results from the RECORDER Project. Rheumatology, 62(12), 3828-3837. https://doi.org/10.1093/rheumatology/kead150

Objectives
To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the second wave of the COVID-19 pandemic in England, and describe the impact of corticosteroids on... Read More about COVID-19 infection, admission and death and the impact of corticosteroids amongst people with rare autoimmune rheumatic disease during the second wave of covid-19 in England: results from the RECORDER Project.

Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models (2023)
Journal Article
Liao, W., Coupland, C., Burchardt, J., Baldwin, D. R., Gleeson, F. V., Hippisley-Cox, J., & DART initiative. (2023). Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models. Lancet Respiratory Medicine, https://doi.org/10.1016/S2213-2600%2823%2900050-4

Background: Lung cancer is the second most common cancer in incidence and the leading cause of cancer deaths worldwide. Meanwhile, lung cancer screening with low-dose CT can reduce mortality. The UK National Screening Committee recommended targeted l... Read More about Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models.

Forehead monitoring of heart rate in neonatal intensive care (2023)
Journal Article
Stockwell, S. J., Kwok, T. C., Morgan, S. P., Sharkey, D., & Hayes-Gill, B. R. (2023). Forehead monitoring of heart rate in neonatal intensive care. Frontiers in Physiology, 14, Article 1127419. https://doi.org/10.3389/fphys.2023.1127419

Heart rate is an extremely important physiological parameter to measure in critically unwell infants, as it is the main physiological marker that changes in response to a change in infant condition. Heart rate is routinely measured peripherally on a... Read More about Forehead monitoring of heart rate in neonatal intensive care.

Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420) (2023)
Journal Article
Gareth Evans, D., McWilliams, L., Astley, S., Brentnall, A. R., Cuzick, J., Dobrashian, R., …French, D. P. (2023). Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420). British Journal of Cancer, 128, 2063-2071. https://doi.org/10.1038/s41416-023-02250-w

Background
Risk stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) could provide a better balance of benefits and harms. We developed BC-Predict, to offer women when invited to the NHSBSP, which collects standard risk fa... Read More about Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420).

Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India: A Multicenter Feasibility Randomized Controlled Trial (2023)
Journal Article
Chattopadhyay, K., Mishra, P., Singh, K., Singh, K., Harris, T., Hamer, M., …YOGA-DP Study Team. (2023). Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India: A Multicenter Feasibility Randomized Controlled Trial. Diabetes Therapy, 14, 1137-1154. https://doi.org/10.1007/s13300-023-01395-4

Introduction: Many Indians are at high risk of type 2 diabetes mellitus (T2DM). The blood glucose level can be improved through a healthy lifestyle (such as physical activity and a healthy diet). Yoga can help in T2DM prevention, being a culturally a... Read More about Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India: A Multicenter Feasibility Randomized Controlled Trial.

Paediatric dermatology teleconsultations: a survey of healthcare professionals in the UK (2023)
Journal Article
McCusker, S., King Stokes, N., Hunjan, M., Daly, A., George, S., Solman, L., & Burden-Teh, E. (2023). Paediatric dermatology teleconsultations: a survey of healthcare professionals in the UK. Clinical and Experimental Dermatology, 48(7), 785-789. https://doi.org/10.1093/ced/llad120

The COVID-19 pandemic catapulted dermatology services into a digital era, with the rapid introduction of teleconsultations. The UK National Health Service operational planning guidance recommends ≥ 25% of consultations are delivered remotely. There i... Read More about Paediatric dermatology teleconsultations: a survey of healthcare professionals in the UK.

Feasibility of a RCT of techniques for managing an impacted fetal head during emergency caesarean section: the MIDAS scoping study (2023)
Journal Article
Walker, K. F., Mitchell, E. J., Ayers, S., Jones, N. W., Ogollah, R., Wakefield, N., …Thornton, J. G. (2023). Feasibility of a RCT of techniques for managing an impacted fetal head during emergency caesarean section: the MIDAS scoping study. Health Technology Assessment, 27(6), 1-87. https://doi.org/10.3310/KUYP6832

Background: Second-stage caesarean sections, of which there are around 34,000 per year in the United Kingdom, have greater maternal and perinatal morbidity than those in the first stage. The fetal head is often deeply impacted in the maternal pelvis,... Read More about Feasibility of a RCT of techniques for managing an impacted fetal head during emergency caesarean section: the MIDAS scoping study.

How do stroke early supported discharge services achieve intensive and responsive service provision? Findings from a realist evaluation study (WISE) (2023)
Journal Article
Chouliara, N., Cameron, T., Byrne, A., Lewis, S., Langhorne, P., Robinson, T., …Fisher, R. (2023). How do stroke early supported discharge services achieve intensive and responsive service provision? Findings from a realist evaluation study (WISE). BMC Health Services Research, 23(1), Article 299. https://doi.org/10.1186/s12913-023-09290-1

Background: Stroke Early Supported Discharge (ESD) involves provision of responsive and intensive rehabilitation to stroke survivors at home and it is recommended as part of the stroke care pathway. Core components have been identified to guide the d... Read More about How do stroke early supported discharge services achieve intensive and responsive service provision? Findings from a realist evaluation study (WISE).

Timing of Allergenic Food Introduction and Risk of Immunoglobulin E–Mediated Food Allergy: A Systematic Review and Meta-analysis (2023)
Journal Article
Scarpone, R., Kimkool, P., Ierodiakonou, D., Leonardi-Bee, J., Garcia-Larsen, V., Perkin, M., & Boyle, R. J. (2023). Timing of Allergenic Food Introduction and Risk of Immunoglobulin E–Mediated Food Allergy: A Systematic Review and Meta-analysis. JAMA Pediatrics, https://doi.org/10.1001/jamapediatrics.2023.0142

Importance: Earlier egg and peanut introduction probably reduce risk of egg or peanut allergy, but it is uncertain whether food allergy as a whole can be prevented using earlier allergenic food introduction.

Objective: This study is a systematic r... Read More about Timing of Allergenic Food Introduction and Risk of Immunoglobulin E–Mediated Food Allergy: A Systematic Review and Meta-analysis.

Ethnic inequalities in COVID-19 infection, hospitalisation, intensive care admission, and death: a global systematic review and meta-analysis of over 200 million study participants (2023)
Journal Article
Irizar, P., Pan, D., Kapadia, D., Bécares, L., Sze, S., Taylor, H., …Pareek, M. (2023). Ethnic inequalities in COVID-19 infection, hospitalisation, intensive care admission, and death: a global systematic review and meta-analysis of over 200 million study participants. eClinicalMedicine, 57, Article 101877. https://doi.org/10.1016/j.eclinm.2023.101877

Background: COVID-19 has exacerbated existing ethnic inequalities in health. Little is known about whether inequalities in severe disease and deaths, observed globally among minoritised ethnic groups, relates to greater infection risk, poorer prognos... Read More about Ethnic inequalities in COVID-19 infection, hospitalisation, intensive care admission, and death: a global systematic review and meta-analysis of over 200 million study participants.

Evaluating the efficacy and safety of single-agent etoposide intra-CSF chemotherapy in children and young people with relapsed/refractory central nervous system tumours (2023)
Journal Article
Butler, A., Meijer, L., Liu, J., Chohan, M., Jalloh, I., Macarthur, D., …Dandapani, M. (2023). Evaluating the efficacy and safety of single-agent etoposide intra-CSF chemotherapy in children and young people with relapsed/refractory central nervous system tumours. Child's Nervous System, 39, 1537-1544. https://doi.org/10.1007/s00381-023-05872-w

Purpose
The aim of the project was to evaluate intra-CSF etoposide administration in a palliative setting for children and young people with relapsed/refractory central nervous system (CNS) tumours, with the primary endpoints being overall survival... Read More about Evaluating the efficacy and safety of single-agent etoposide intra-CSF chemotherapy in children and young people with relapsed/refractory central nervous system tumours.

Case Series of Genetically Confirmed Index Cases of Familial Hypercholesterolemia in Primary Care (2023)
Journal Article
Kamal, A., Kanchau, J. D., Shahuri, N. S., Mohamed-Yassin, M. S., Baharudin, N., Razak, S. A., …Ramli, A. S. (2023). Case Series of Genetically Confirmed Index Cases of Familial Hypercholesterolemia in Primary Care. American Journal of Case Reports, 24, Article e939489. https://doi.org/10.12659/AJCR.939489

BACKGROUND: In Malaysia, the prevalence of genetically confirmed heterozygous familial hypercholesterolemia (FH) was reported as 1 in 427. Despite this, FH remains largely underdiagnosed and undertreated in primary care.

CASE REPORT: In this case... Read More about Case Series of Genetically Confirmed Index Cases of Familial Hypercholesterolemia in Primary Care.

Induction of labour (2023)
Journal Article
Azhur, S., & Walker, K. F. (2023). Induction of labour. Obstetrics, Gynaecology and Reproductive Medicine, 33(5), 121-128. https://doi.org/10.1016/j.ogrm.2023.02.001

Induction of labour describes the artificial stimulation of the onset of labour and occurs in up to 30% of pregnancies in the United Kingdom. Both mechanical and pharmacological methods of induction of labour exist. Induction of labour is associated... Read More about Induction of labour.

Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health (2023)
Journal Article
Jones, E. J., Ayling, K., Wiley, C. R., Geraghty, A. W., Greer, A. L., Holt-Lunstad, J., …Vedhara, K. (2023). Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health. Policy Insights from the Behavioral and Brain Sciences, 10(1), 33-40. https://doi.org/10.1177/23727322221145308

Psychosocial factors are related to immune, viral, and vaccination outcomes. Yet, this knowledge has been poorly represented in public health initiatives during the COVID-19 pandemic. This review provides an overview of biopsychosocial links relevant... Read More about Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health.

A systematic review and meta-analysis of suicidality in autistic and possibly autistic people without co-occurring intellectual disability (2023)
Journal Article
Newell, V., Phillips, L., Jones, C., Townsend, E., Richards, C., & Cassidy, S. (2023). A systematic review and meta-analysis of suicidality in autistic and possibly autistic people without co-occurring intellectual disability. Molecular Autism, 14, Article 12. https://doi.org/10.1186/s13229-023-00544-7

Background: Suicidality is highly prevalent in autistic people without co-occurring intellectual disabilities, and high autistic traits are found in adults who have attempted suicide. However, prevalence rates for both autistic and possibly autistic... Read More about A systematic review and meta-analysis of suicidality in autistic and possibly autistic people without co-occurring intellectual disability.

A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination (2023)
Journal Article
Spiegel, K., Rey, A. E., Cheylus, A., Ayling, K., Benedict, C., Lange, T., …Van Cauter, E. (2023). A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination. Current Biology, 33(5), 998-1005.e2. https://doi.org/10.1016/j.cub.2023.02.017

Vaccination is a major strategy to control a viral pandemic. Simple behavioral interventions that might boost vaccine responses have yet to be identified. We conducted meta-analyses to summarize the evidence linking the amount of sleep obtained in th... Read More about A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination.

Wound healing and healing process in patients with diabetic foot ulcers: A survival analysis study (2023)
Journal Article
Graça Pereira, M., Vilaça, M., Pedras, S., Carvalho, A., Vedhara, K., Jesus Dantas, M., & Machado, L. (2023). Wound healing and healing process in patients with diabetic foot ulcers: A survival analysis study. Diabetes Research and Clinical Practice, 198, Article 110623. https://doi.org/10.1016/j.diabres.2023.110623

Aims: This study aimed to identify demographic, clinical, and psychological contributors to DFU healing and favorable healing process. Methods: Patients with a chronic DFU were evaluated at baseline (T0; n = 153), two months later (T1; n = 108), and... Read More about Wound healing and healing process in patients with diabetic foot ulcers: A survival analysis study.

Comparison of a Daily Smartphone App and Retrospective Questionnaire Measures of Adherence to Nicotine Replacement Therapy Among Pregnant Women: Observational Study (2023)
Journal Article
Emery, J., Naughton, F., Huang, Y., Cooper, S., McDaid, L., Dickinson, A., …Coleman, T. (2023). Comparison of a Daily Smartphone App and Retrospective Questionnaire Measures of Adherence to Nicotine Replacement Therapy Among Pregnant Women: Observational Study. JMIR Formative Research, 7, Article e35045. https://doi.org/10.2196/35045

Background: Few studies have investigated how to best measure adherence to smoking cessation medications, but continuous usage measures are recommended. Objective: In this first study of its kind, we compared methods for measuring adherence to nicoti... Read More about Comparison of a Daily Smartphone App and Retrospective Questionnaire Measures of Adherence to Nicotine Replacement Therapy Among Pregnant Women: Observational Study.

Assessing and investigating children with suspected bone and abdominal tumours: an e-Delphi consensus process (2023)
Journal Article
Shanmugavadivel, D., Liu, J. F., Gamble, A., Polanco, A., Vedhara, K., Walker, D., & Ojha, S. (2023). Assessing and investigating children with suspected bone and abdominal tumours: an e-Delphi consensus process. BMJ Paediatrics Open, 7, Article e001771. https://doi.org/10.1136/bmjpo-2022-001771

Background The incidence of childhood cancer has risen by 15% since the 1990s. Early diagnosis is key to optimising outcomes, however diagnostic delays are widely reported. Presenting symptoms are often non-specific causing a diagnostic dilemma for c... Read More about Assessing and investigating children with suspected bone and abdominal tumours: an e-Delphi consensus process.

Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration (2023)
Journal Article
Cattell, M., Hyde, K., Bell, B., Dawson, T., Hills, T., Iyen, B., …Avery, A. (in press). Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration. European Journal of Hospital Pharmacy, Article 003515. https://doi.org/10.1136/ejhpharm-2022-003515

Objectives
To describe the frequency of the different types of medication-related incidents that caused patient harm, or adverse consequences, in a major teaching hospital and investigate whether the likelihood of these incidents occurring would hav... Read More about Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration.