Dr KAUSHIK CHATTOPADHYAY KAUSHIK.CHATTOPADHYAY@NOTTINGHAM.AC.UK
ASSOCIATE PROFESSOR
Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India: A Multicenter Feasibility Randomized Controlled Trial
Chattopadhyay, Kaushik; Mishra, Pallavi; Singh, Kavita; Singh, Kalpana; Harris, Tess; Hamer, Mark; Greenfield, Sheila Margaret; Manjunath, Nandi Krishnamurthy; Nair, Rukamani; Mukherjee, Somnath; Tandon, Nikhil; Lewis, Sarah Anne; Kinra, Sanjay; Prabhakaran, Dorairaj; YOGA-DP Study Team
Authors
Pallavi Mishra
Kavita Singh
Kalpana Singh
Tess Harris
Mark Hamer
Sheila Margaret Greenfield
Nandi Krishnamurthy Manjunath
Rukamani Nair
Somnath Mukherjee
Nikhil Tandon
Sarah Anne Lewis
Sanjay Kinra
Dorairaj Prabhakaran
YOGA-DP Study Team
Abstract
Introduction: Many Indians are at high risk of type 2 diabetes mellitus (T2DM). The blood glucose level can be improved through a healthy lifestyle (such as physical activity and a healthy diet). Yoga can help in T2DM prevention, being a culturally appropriate approach to improving lifestyle. We developed the Yoga Programme for T2DM Prevention (YOGA-DP), a 24-week structured lifestyle education and exercise (Yoga) program that included 27 group Yoga sessions and self-practice of Yoga at home. In this study, the feasibility of undertaking a definitive randomized controlled trial (RCT) was explored that will evaluate the intervention’s effectiveness among high-risk individuals in India. Methods: A multicenter, two-arm, parallel-group, feasibility RCT was conducted in India. The outcome assessors and data analysts were blinded. Adults with a fasting blood glucose level of 100–125mg/dL (i.e., at high risk of T2DM) were eligible. Participants were randomized centrally using a computer-generated randomization schedule. In the intervention group, participants received YOGA-DP. In the control group, participants received enhanced standard care. Results: In this feasibility trial, the recruitment of participants took 4 months (from May to September 2019). We screened 711 people and assessed 160 for eligibility. Sixty-five participants (33 in the intervention group and 32 in the control group) were randomized, and 57 (88%) participants were followed up for 6 months (32 in the intervention group and 25 in the control group). In the intervention group, the group Yoga sessions were continuously attended by 32 (97%) participants (median (interquartile range, IQR) number of sessions attended = 27(3)). In the intervention group, Yoga was self-practiced at home by 30 (91%) participants (median (IQR) number of days per week and minutes per day self-practiced = 2(2) and 35(15), respectively). In the control group, one (3%) participant attended external Yoga sessions (on Pranayama) for 1 week during the feasibility trial period. There was no serious adverse event. Conclusions: The participant recruitment and follow-up and adherence to the intervention were promising in this feasibility study. In the control group, the potential contamination was low. Therefore, it should be feasible to undertake a definitive RCT in the future that will evaluate YOGA-DP’s effectiveness among high-risk people in India. Feasibility Trial Registration: Clinical Trials Registry—India (CTRI) CTRI/2019/05/018893; registered on May1, 2019.
Citation
Chattopadhyay, K., Mishra, P., Singh, K., Singh, K., Harris, T., Hamer, M., Greenfield, S. M., Manjunath, N. K., Nair, R., Mukherjee, S., Tandon, N., Lewis, S. A., Kinra, S., Prabhakaran, D., & YOGA-DP Study Team. (2023). Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India: A Multicenter Feasibility Randomized Controlled Trial. Diabetes Therapy, 14, 1137-1154. https://doi.org/10.1007/s13300-023-01395-4
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 8, 2023 |
Online Publication Date | Mar 31, 2023 |
Publication Date | 2023-07 |
Deposit Date | Mar 17, 2023 |
Publicly Available Date | Mar 17, 2023 |
Journal | Diabetes Therapy |
Print ISSN | 1869-6953 |
Electronic ISSN | 1869-6961 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 14 |
Pages | 1137-1154 |
DOI | https://doi.org/10.1007/s13300-023-01395-4 |
Keywords | Blood glucose; diet; feasibility study; lifestyle; Yoga; physical activity; prediabetes; prevention; randomized controlled trial |
Public URL | https://nottingham-repository.worktribe.com/output/18528683 |
Publisher URL | https://link.springer.com/article/10.1007/s13300-023-01395-4 |
Files
Yoga-DP Manuscript Final 7 March 2023 Kaushik Chattopadhya
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Licence
https://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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