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A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination

Spiegel, Karine; Rey, Amandine E.; Cheylus, Anne; Ayling, Kieran; Benedict, Christian; Lange, Tanja; Prather, Aric A.; Taylor, Daniel J.; Irwin, Michael R.; Van Cauter, Eve

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Authors

Karine Spiegel

Amandine E. Rey

Anne Cheylus

Christian Benedict

Tanja Lange

Aric A. Prather

Daniel J. Taylor

Michael R. Irwin

Eve Van Cauter



Abstract

Vaccination is a major strategy to control a viral pandemic. Simple behavioral interventions that might boost vaccine responses have yet to be identified. We conducted meta-analyses to summarize the evidence linking the amount of sleep obtained in the days surrounding vaccination to antibody response in healthy adults. Authors of the included studies provided the information needed to accurately estimate the pooled effect size (ES) and 95% confidence intervals (95% CI) and to examine sex differences. The association between self-reported short sleep (<6 h/night) and reduced vaccine response did not reach our pre-defined statistical significant criteria (total n = 504, ages 18–85; overall ES [95% CI] = 0.29 [−0.04, 0.63]). Objectively assessed short sleep was associated with a robust decrease in antibody response (total n = 304, ages 18–60; overall ES [95% CI] = 0.79 [0.40, 1.18]). In men, the pooled ES was large (overall ES [95% CI] = 0.93 [0.54, 1.33]), whereas it did not reach significance in women (overall ES [95% CI] = 0.42 [−0.49, 1.32]). These results provide evidence that insufficient sleep duration substantially decreases the response to anti-viral vaccination and suggests that achieving adequate amount of sleep during the days surrounding vaccination may enhance and prolong the humoral response. Large-scale well-controlled studies are urgently needed to define (1) the window of time around inoculation when optimizing sleep duration is most beneficial, (2) the causes of the sex disparity in the impact of sleep on the response, and (3) the amount of sleep needed to protect the response.

Citation

Spiegel, K., Rey, A. E., Cheylus, A., Ayling, K., Benedict, C., Lange, T., …Van Cauter, E. (2023). A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination. Current Biology, 33(5), 998-1005.e2. https://doi.org/10.1016/j.cub.2023.02.017

Journal Article Type Article
Acceptance Date Feb 16, 2023
Online Publication Date Mar 13, 2023
Publication Date Mar 13, 2023
Deposit Date Mar 17, 2023
Publicly Available Date Mar 29, 2024
Journal Current Biology
Print ISSN 0960-9822
Electronic ISSN 1879-0445
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 33
Issue 5
Pages 998-1005.e2
DOI https://doi.org/10.1016/j.cub.2023.02.017
Keywords Sleep duration; anti-viral vaccination; antibody response; seroprotection; sex differences; effect size; meta-analysis
Public URL https://nottingham-repository.worktribe.com/output/18527840

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