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A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination

Spiegel, Karine; Rey, Amandine E.; Cheylus, Anne; Ayling, Kieran; Benedict, Christian; Lange, Tanja; Prather, Aric A.; Taylor, Daniel J.; Irwin, Michael R.; Van Cauter, Eve


Karine Spiegel

Amandine E. Rey

Anne Cheylus

Christian Benedict

Tanja Lange

Aric A. Prather

Daniel J. Taylor

Michael R. Irwin

Eve Van Cauter


Vaccination is a major strategy to control a viral pandemic. Simple behavioral interventions that might boost vaccine responses have yet to be identified. We conducted meta-analyses to summarize the evidence linking the amount of sleep obtained in the days surrounding vaccination to antibody response in healthy adults. Authors of the included studies provided the information needed to accurately estimate the pooled effect size (ES) and 95% confidence intervals (95% CI) and to examine sex differences. The association between self-reported short sleep (<6 h/night) and reduced vaccine response did not reach our pre-defined statistical significant criteria (total n = 504, ages 18–85; overall ES [95% CI] = 0.29 [−0.04, 0.63]). Objectively assessed short sleep was associated with a robust decrease in antibody response (total n = 304, ages 18–60; overall ES [95% CI] = 0.79 [0.40, 1.18]). In men, the pooled ES was large (overall ES [95% CI] = 0.93 [0.54, 1.33]), whereas it did not reach significance in women (overall ES [95% CI] = 0.42 [−0.49, 1.32]). These results provide evidence that insufficient sleep duration substantially decreases the response to anti-viral vaccination and suggests that achieving adequate amount of sleep during the days surrounding vaccination may enhance and prolong the humoral response. Large-scale well-controlled studies are urgently needed to define (1) the window of time around inoculation when optimizing sleep duration is most beneficial, (2) the causes of the sex disparity in the impact of sleep on the response, and (3) the amount of sleep needed to protect the response.


Spiegel, K., Rey, A. E., Cheylus, A., Ayling, K., Benedict, C., Lange, T., …Van Cauter, E. (2023). A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination. Current Biology, 33(5), 998-1005.e2.

Journal Article Type Article
Acceptance Date Feb 16, 2023
Online Publication Date Mar 13, 2023
Publication Date 2023-03
Deposit Date Mar 17, 2023
Publicly Available Date Mar 14, 2024
Journal Current Biology
Print ISSN 0960-9822
Publisher Cell Press
Peer Reviewed Peer Reviewed
Volume 33
Issue 5
Pages 998-1005.e2
Keywords General Agricultural and Biological Sciences; General Biochemistry, Genetics and Molecular Biology
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