All Outputs (26)

Understanding the current nutritional management for people with amyotrophic lateral sclerosis - A mapping review (2022)
Journal Article
Essat, M., Coates, E., Clowes, M., Beever, D., Hackney, G., White, S., …McDermott, C. (2022). Understanding the current nutritional management for people with amyotrophic lateral sclerosis - A mapping review. Clinical Nutrition ESPEN, 49, 328-340. https://doi.org/10.1016/j.clnesp.2022.03.026

Background & aims Poor nutritional outcomes are observed in people with Amyotrophic Lateral Sclerosis (pwALS) including weight loss and poor dietary intake. Surveys of healthcare professionals have highlighted the lack of evidence and knowledge rega... Read More about Understanding the current nutritional management for people with amyotrophic lateral sclerosis - A mapping review.

Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis (2022)
Working Paper
Middleton, S., Chalitsios, C., McKeever, T. M., Jenkins, A. R., & Bolton, C. E. Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis

Background Acute COVID-19 clinical symptoms have been clearly documented, but long-term functional and symptomatic recovery from COVID -19 is less well described. Methods A systematic review and meta-analysis were conducted to describe patient-rep... Read More about Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis.

Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomised controlled trial (2022)
Journal Article
Hancox, J., Ayling, K., Bedford, L., Vedhara, K., Robertson, J. F. R., Young, B., …Kendrick., D. (2023). Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomised controlled trial. Journal of Public Health, 45(2), e275–e284. https://doi.org/10.1093/pubmed/fdac032

Background: The Early CDT®-Lung antibody blood test plus serial CT-scans for test-positives reduces late-stage lung cancer presentation. This study assessed psychological outcomes of this approach. Methods: Randomised controlled trial (n=12,208) c... Read More about Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomised controlled trial.

Is it possible to implement a rare disease case-finding tool in primary care? A UK-based pilot study (2022)
Journal Article
Buendia, O., Shankar, S., Mahon, H., Toal, C., Menzies, L., Ravichandran, P., …Evans, W. (2022). Is it possible to implement a rare disease case-finding tool in primary care? A UK-based pilot study. Orphanet Journal of Rare Diseases, 17, Article 54. https://doi.org/10.1186/s13023-022-02216-w

Introduction: This study implemented MendelScan, a primary care rare disease case-finding tool, into a UK National Health Service population. Rare disease diagnosis is challenging due to disease complexity and low physician awareness. The 2021 UK Rar... Read More about Is it possible to implement a rare disease case-finding tool in primary care? A UK-based pilot study.

Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis (2022)
Journal Article
Webb, K., Zain, N. M. M., Stewart, I., Fogarty, A., Nash, E. F., Whitehouse, J. L., …Barr, H. L. (2022). Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis. Journal of Medical Microbiology, 71(2), Article 001481. https://doi.org/10.1099/jmm.0.001481

Although anaerobic bacteria exist in abundance in cystic fibrosis (CF) airways, their role in disease progression is poorly understood. We hypothesized that the presence and relative abundance of the most prevalent, live, anaerobic bacteria in sputum... Read More about Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis.

Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study (2022)
Journal Article
Swain, S., Coupland, C., Strauss, V., Mallen, C., Kuo, C. F., Sarmanova, A., …Zhang, W. (2022). Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study. Osteoarthritis and Cartilage, 30(5), 702-713. https://doi.org/10.1016/j.joca.2021.12.013

Objective: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. Methods: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with in... Read More about Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study.